Efficacy of Antimicrobial Photodynamic Therapy for Treating Moderate to Deep Periodontal Pockets in Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
<b>Background/Objectives:</b> Diabetes mellitus and periodontitis share a significant, bidirectional relationship. Diabetes raises the risk of periodontitis and influences its severity, impacting tissue repair and bone metabolism. Conversely, periodontal inflammation can disrupt glycemic...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Dentistry Journal |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6767/13/1/21 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588701188751360 |
|---|---|
| author | João Victor Soares Rodrigues Mariella Boaretti Deroide Wilton Mitsunari Takeshita Valdir Gouveia Garcia Rafael Scaf de Molon Leticia Helena Theodoro |
| author_facet | João Victor Soares Rodrigues Mariella Boaretti Deroide Wilton Mitsunari Takeshita Valdir Gouveia Garcia Rafael Scaf de Molon Leticia Helena Theodoro |
| author_sort | João Victor Soares Rodrigues |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Diabetes mellitus and periodontitis share a significant, bidirectional relationship. Diabetes raises the risk of periodontitis and influences its severity, impacting tissue repair and bone metabolism. Conversely, periodontal inflammation can disrupt glycemic control, further complicating this interlinked relationship. This systematic review aimed to evaluate the efficacy of antimicrobial photodynamic therapy (aPDT) as an adjunct to subgingival instrumentation (SI) in the treatment of periodontal pockets with a probing pocket depth (PPD) ≥ 5 mm in individuals with type 2 diabetes mellitus (DM2) and periodontitis. <b>Methods:</b> Using the PICOS framework, this review addressed the following question: “How does aPDT as an adjunct to SI compare to SI alone in treating periodontal pockets with PPD ≥ 5 mm in individuals with DM2 and periodontitis?” Databases searched included PubMed, Scopus, and Web of Science up to December 2024. Randomized clinical trials evaluating periodontal status and HbA1c levels in patients with DM2 undergoing periodontal therapy and experiencing SI were included. Patients who received adjunctive aPDT were compared to a control group that received SI alone. A meta-analysis was conducted illustrating treatment effects across groups. <b>Results:</b> After screening 117 studies based on titles and abstracts, three and four studies met the eligibility criteria for quantitative and qualitative analyses, respectively. The principal periodontal parameters assessed included PPD, clinical attachment level (CAL), plaque index (PI), and bleeding on probing (BOP). Forest plots for PD, BOP, PI, and CAL at baseline, three months, and six months revealed no statistically significant differences between the SI+aPDT group and the SI-only group. Glycated hemoglobin across treatment groups was not different. <b>Conclusions:</b> The combination of aPDT with SI provides limited clinical benefits in treating periodontal pockets with a PPD ≥ 5 mm in diabetic patients with periodontitis. |
| format | Article |
| id | doaj-art-698ca0362a344248ae1f03a0f588f09f |
| institution | Kabale University |
| issn | 2304-6767 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj-art-698ca0362a344248ae1f03a0f588f09f2025-01-24T13:28:38ZengMDPI AGDentistry Journal2304-67672025-01-011312110.3390/dj13010021Efficacy of Antimicrobial Photodynamic Therapy for Treating Moderate to Deep Periodontal Pockets in Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-AnalysisJoão Victor Soares Rodrigues0Mariella Boaretti Deroide1Wilton Mitsunari Takeshita2Valdir Gouveia Garcia3Rafael Scaf de Molon4Leticia Helena Theodoro5Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, BrazilDepartment of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, BrazilDepartment of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, BrazilLatin American Institute of Dental Research and Teaching (ILAPEO), Curitiba 80710-150, PR, BrazilDepartment of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, BrazilDepartment of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araçatuba 16015-050, SP, Brazil<b>Background/Objectives:</b> Diabetes mellitus and periodontitis share a significant, bidirectional relationship. Diabetes raises the risk of periodontitis and influences its severity, impacting tissue repair and bone metabolism. Conversely, periodontal inflammation can disrupt glycemic control, further complicating this interlinked relationship. This systematic review aimed to evaluate the efficacy of antimicrobial photodynamic therapy (aPDT) as an adjunct to subgingival instrumentation (SI) in the treatment of periodontal pockets with a probing pocket depth (PPD) ≥ 5 mm in individuals with type 2 diabetes mellitus (DM2) and periodontitis. <b>Methods:</b> Using the PICOS framework, this review addressed the following question: “How does aPDT as an adjunct to SI compare to SI alone in treating periodontal pockets with PPD ≥ 5 mm in individuals with DM2 and periodontitis?” Databases searched included PubMed, Scopus, and Web of Science up to December 2024. Randomized clinical trials evaluating periodontal status and HbA1c levels in patients with DM2 undergoing periodontal therapy and experiencing SI were included. Patients who received adjunctive aPDT were compared to a control group that received SI alone. A meta-analysis was conducted illustrating treatment effects across groups. <b>Results:</b> After screening 117 studies based on titles and abstracts, three and four studies met the eligibility criteria for quantitative and qualitative analyses, respectively. The principal periodontal parameters assessed included PPD, clinical attachment level (CAL), plaque index (PI), and bleeding on probing (BOP). Forest plots for PD, BOP, PI, and CAL at baseline, three months, and six months revealed no statistically significant differences between the SI+aPDT group and the SI-only group. Glycated hemoglobin across treatment groups was not different. <b>Conclusions:</b> The combination of aPDT with SI provides limited clinical benefits in treating periodontal pockets with a PPD ≥ 5 mm in diabetic patients with periodontitis.https://www.mdpi.com/2304-6767/13/1/21diabetes mellitusperiodontal diseaseperiodontal pocketphotochemotherapyphotosensitizing agents |
| spellingShingle | João Victor Soares Rodrigues Mariella Boaretti Deroide Wilton Mitsunari Takeshita Valdir Gouveia Garcia Rafael Scaf de Molon Leticia Helena Theodoro Efficacy of Antimicrobial Photodynamic Therapy for Treating Moderate to Deep Periodontal Pockets in Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Dentistry Journal diabetes mellitus periodontal disease periodontal pocket photochemotherapy photosensitizing agents |
| title | Efficacy of Antimicrobial Photodynamic Therapy for Treating Moderate to Deep Periodontal Pockets in Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_full | Efficacy of Antimicrobial Photodynamic Therapy for Treating Moderate to Deep Periodontal Pockets in Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_fullStr | Efficacy of Antimicrobial Photodynamic Therapy for Treating Moderate to Deep Periodontal Pockets in Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Efficacy of Antimicrobial Photodynamic Therapy for Treating Moderate to Deep Periodontal Pockets in Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_short | Efficacy of Antimicrobial Photodynamic Therapy for Treating Moderate to Deep Periodontal Pockets in Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_sort | efficacy of antimicrobial photodynamic therapy for treating moderate to deep periodontal pockets in individuals with type 2 diabetes mellitus a systematic review and meta analysis |
| topic | diabetes mellitus periodontal disease periodontal pocket photochemotherapy photosensitizing agents |
| url | https://www.mdpi.com/2304-6767/13/1/21 |
| work_keys_str_mv | AT joaovictorsoaresrodrigues efficacyofantimicrobialphotodynamictherapyfortreatingmoderatetodeepperiodontalpocketsinindividualswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT mariellaboarettideroide efficacyofantimicrobialphotodynamictherapyfortreatingmoderatetodeepperiodontalpocketsinindividualswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT wiltonmitsunaritakeshita efficacyofantimicrobialphotodynamictherapyfortreatingmoderatetodeepperiodontalpocketsinindividualswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT valdirgouveiagarcia efficacyofantimicrobialphotodynamictherapyfortreatingmoderatetodeepperiodontalpocketsinindividualswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT rafaelscafdemolon efficacyofantimicrobialphotodynamictherapyfortreatingmoderatetodeepperiodontalpocketsinindividualswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT leticiahelenatheodoro efficacyofantimicrobialphotodynamictherapyfortreatingmoderatetodeepperiodontalpocketsinindividualswithtype2diabetesmellitusasystematicreviewandmetaanalysis |