HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample
Objective. The aim of the study was to determine the prevalence of HIV-associated oral mucosal melanin hyperpigmentation (HIV-OMH) in a specific population of HIV-seropositive South Africans and to analyse the associations between HIV-OMH clinical features and the demographic and immunological chara...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2016/8389214 |
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| author | R. Chandran L. Feller J. Lemmer R. A. G. Khammissa |
| author_facet | R. Chandran L. Feller J. Lemmer R. A. G. Khammissa |
| author_sort | R. Chandran |
| collection | DOAJ |
| description | Objective. The aim of the study was to determine the prevalence of HIV-associated oral mucosal melanin hyperpigmentation (HIV-OMH) in a specific population of HIV-seropositive South Africans and to analyse the associations between HIV-OMH clinical features and the demographic and immunological characteristics of the study cohort. Material and Methods. This cross-sectional study included 200 HIV-seropositive Black subjects. The collected data comprised age, gender, CD4+ T cell count, viral load, systemic disease, medications, oral site affected by HIV-OMH, extent (localized or generalized), intensity of the pigmentation (dark or light), and smoking and snuff use. Results. Overall, 18.5% of the study cohort had HIV-OMH. Twenty-two and a half percent had OMH that could not with confidence be attributed to HIV infection, and 59% did not have any OMH. There was a significant but weak association between smoking and the presence of HIV-OMH. Conclusions. The prevalence of HIV-OMH in the study population was 18.5%, the gingiva being the most commonly affected site. It appears that the CD4+ T cell count does not play any role in the biopathology of HIV-OMH. |
| format | Article |
| id | doaj-art-697ed0e68dd64a5d9b2b341fe4305696 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-697ed0e68dd64a5d9b2b341fe43056962025-02-03T05:57:11ZengWileyAIDS Research and Treatment2090-12402090-12592016-01-01201610.1155/2016/83892148389214HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population SampleR. Chandran0L. Feller1J. Lemmer2R. A. G. Khammissa3Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South AfricaDepartment of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South AfricaDepartment of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South AfricaDepartment of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South AfricaObjective. The aim of the study was to determine the prevalence of HIV-associated oral mucosal melanin hyperpigmentation (HIV-OMH) in a specific population of HIV-seropositive South Africans and to analyse the associations between HIV-OMH clinical features and the demographic and immunological characteristics of the study cohort. Material and Methods. This cross-sectional study included 200 HIV-seropositive Black subjects. The collected data comprised age, gender, CD4+ T cell count, viral load, systemic disease, medications, oral site affected by HIV-OMH, extent (localized or generalized), intensity of the pigmentation (dark or light), and smoking and snuff use. Results. Overall, 18.5% of the study cohort had HIV-OMH. Twenty-two and a half percent had OMH that could not with confidence be attributed to HIV infection, and 59% did not have any OMH. There was a significant but weak association between smoking and the presence of HIV-OMH. Conclusions. The prevalence of HIV-OMH in the study population was 18.5%, the gingiva being the most commonly affected site. It appears that the CD4+ T cell count does not play any role in the biopathology of HIV-OMH.http://dx.doi.org/10.1155/2016/8389214 |
| spellingShingle | R. Chandran L. Feller J. Lemmer R. A. G. Khammissa HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample AIDS Research and Treatment |
| title | HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample |
| title_full | HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample |
| title_fullStr | HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample |
| title_full_unstemmed | HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample |
| title_short | HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample |
| title_sort | hiv associated oral mucosal melanin hyperpigmentation a clinical study in a south african population sample |
| url | http://dx.doi.org/10.1155/2016/8389214 |
| work_keys_str_mv | AT rchandran hivassociatedoralmucosalmelaninhyperpigmentationaclinicalstudyinasouthafricanpopulationsample AT lfeller hivassociatedoralmucosalmelaninhyperpigmentationaclinicalstudyinasouthafricanpopulationsample AT jlemmer hivassociatedoralmucosalmelaninhyperpigmentationaclinicalstudyinasouthafricanpopulationsample AT ragkhammissa hivassociatedoralmucosalmelaninhyperpigmentationaclinicalstudyinasouthafricanpopulationsample |