Bing and Neel Syndrome
Introduction. We report the case of a Bing and Neel syndrome revealed by an isolated left ptosis. Case Report. a 57-year-old man was followed up since October 2003 for a typical Waldenström’s macroglobulinemia. A first complete remission was obtained with chlorambucil. In August 2004, he relapsed. A...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/845091 |
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| author | S. Jennane K. Doghmi E. M. Mahtat N. Messaoudi B. Varet M. Mikdame |
| author_facet | S. Jennane K. Doghmi E. M. Mahtat N. Messaoudi B. Varet M. Mikdame |
| author_sort | S. Jennane |
| collection | DOAJ |
| description | Introduction. We report the case of a Bing and Neel syndrome revealed by an isolated left ptosis. Case Report. a 57-year-old man was followed up since October 2003 for a typical Waldenström’s macroglobulinemia. A first complete remission was obtained with chlorambucil. In August 2004, he relapsed. A second complete remission was obtained with RFC chemotherapy regimen (rituximab, fludarabine, and cyclophosphamide). In October 2009, the patient presented with an isolated left ptosis revealing a Bing and Neel syndrome. The diagnosis was suspected on MRI and confirmed by the detection in the CSF of a monoclonal IgM similar to the one found in the plasma. A quite good partial remission has been obtained after one course of RDHAP (rituximab, dexamethasone, cytarabine, and cisplatin) and 3 courses of RDHOx (rituximab, dexamethasone, cytarabine, and oxaliplatin), in addition to ten intrahectal chemotherapy injections. The treatment was followed by intensification and autologous stem cell transplantation. At D58, the patient died due to a septic shock. Conclusion. BNS is a rare and potentially treatable complication of WM. It should be considered in patients with neurologic symptoms and a history of WM. |
| format | Article |
| id | doaj-art-69757618997c4645bb841599beca3a10 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-69757618997c4645bb841599beca3a102025-02-03T07:25:44ZengWileyCase Reports in Hematology2090-65602090-65792012-01-01201210.1155/2012/845091845091Bing and Neel SyndromeS. Jennane0K. Doghmi1E. M. Mahtat2N. Messaoudi3B. Varet4M. Mikdame5Service d’Hématologie Clinique, Hôpital Militaire d’Instruction Mohammed V, Rabat, MoroccoService d’Hématologie Clinique, Hôpital Militaire d’Instruction Mohammed V, Rabat, MoroccoService d’Hématologie Clinique, Hôpital Militaire d’Instruction Mohammed V, Rabat, MoroccoLaboratoire d’Hématologie, Hôpital Militaire d’Instruction Mohammed V, Rabat, MoroccoService d’Hématologie Clinique, Hôpital Necker-Enfants Malades, 75015 Paris, FranceService d’Hématologie Clinique, Hôpital Militaire d’Instruction Mohammed V, Rabat, MoroccoIntroduction. We report the case of a Bing and Neel syndrome revealed by an isolated left ptosis. Case Report. a 57-year-old man was followed up since October 2003 for a typical Waldenström’s macroglobulinemia. A first complete remission was obtained with chlorambucil. In August 2004, he relapsed. A second complete remission was obtained with RFC chemotherapy regimen (rituximab, fludarabine, and cyclophosphamide). In October 2009, the patient presented with an isolated left ptosis revealing a Bing and Neel syndrome. The diagnosis was suspected on MRI and confirmed by the detection in the CSF of a monoclonal IgM similar to the one found in the plasma. A quite good partial remission has been obtained after one course of RDHAP (rituximab, dexamethasone, cytarabine, and cisplatin) and 3 courses of RDHOx (rituximab, dexamethasone, cytarabine, and oxaliplatin), in addition to ten intrahectal chemotherapy injections. The treatment was followed by intensification and autologous stem cell transplantation. At D58, the patient died due to a septic shock. Conclusion. BNS is a rare and potentially treatable complication of WM. It should be considered in patients with neurologic symptoms and a history of WM.http://dx.doi.org/10.1155/2012/845091 |
| spellingShingle | S. Jennane K. Doghmi E. M. Mahtat N. Messaoudi B. Varet M. Mikdame Bing and Neel Syndrome Case Reports in Hematology |
| title | Bing and Neel Syndrome |
| title_full | Bing and Neel Syndrome |
| title_fullStr | Bing and Neel Syndrome |
| title_full_unstemmed | Bing and Neel Syndrome |
| title_short | Bing and Neel Syndrome |
| title_sort | bing and neel syndrome |
| url | http://dx.doi.org/10.1155/2012/845091 |
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