Cisplatin resistance alters ovarian cancer spheroid formation and impacts peritoneal invasion

Cisplatin resistance alters ovarian cancer spheroid formation and impacts peritoneal invasion

Epithelial ovarian cancer (EOC) is an aggressive and lethal gynaecologic malignancy due to late diagnosis and acquired resistance to chemotherapeutic drugs, such as cisplatin. EOC metastasis commonly occurs through the extensive dissemination of multicellular aggregates, formed of cells originally s...

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Bibliographic Details
Main Authors: Lydia C. Powell, Marcos Quintela, David W. James, Emenike Onyido, David Howard, Kadie Edwards, Jordan L. Turney, Charlotte R. Morgan, Jenny Worthington, Nicole Williams, Alexander Dulebo, Heiko Haschke, Deyarina Gonzalez, R. Steven Conlan, Lewis W. Francis
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ovarian cancer
spheroids
biophysics
invasion
atomic force microscopy
cisplatin
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1450407/full
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