CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making.
Here we introduce CBGTPy, a virtual environment for designing and testing goal-directed agents with internal dynamics that are modeled on the cortico-basal-ganglia-thalamic (CBGT) pathways in the mammalian brain. CBGTPy enables researchers to investigate the internal dynamics of the CBGT system duri...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0310367 |
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| author | Matthew Clapp Jyotika Bahuguna Cristina Giossi Jonathan E Rubin Timothy Verstynen Catalina Vich |
| author_facet | Matthew Clapp Jyotika Bahuguna Cristina Giossi Jonathan E Rubin Timothy Verstynen Catalina Vich |
| author_sort | Matthew Clapp |
| collection | DOAJ |
| description | Here we introduce CBGTPy, a virtual environment for designing and testing goal-directed agents with internal dynamics that are modeled on the cortico-basal-ganglia-thalamic (CBGT) pathways in the mammalian brain. CBGTPy enables researchers to investigate the internal dynamics of the CBGT system during a variety of tasks, allowing for the formation of testable predictions about animal behavior and neural activity. The framework has been designed around the principle of flexibility, such that many experimental parameters in a decision making paradigm can be easily defined and modified. Here we demonstrate the capabilities of CBGTPy across a range of single and multi-choice tasks, highlighting the ease of set up and the biologically realistic behavior that it produces. We show that CBGTPy is extensible enough to apply to a range of experimental protocols and to allow for the implementation of model extensions with minimal developmental effort. |
| format | Article |
| id | doaj-art-69655e7d646547a498518c7ed17cd42b |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-69655e7d646547a498518c7ed17cd42b2025-02-05T05:31:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031036710.1371/journal.pone.0310367CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making.Matthew ClappJyotika BahugunaCristina GiossiJonathan E RubinTimothy VerstynenCatalina VichHere we introduce CBGTPy, a virtual environment for designing and testing goal-directed agents with internal dynamics that are modeled on the cortico-basal-ganglia-thalamic (CBGT) pathways in the mammalian brain. CBGTPy enables researchers to investigate the internal dynamics of the CBGT system during a variety of tasks, allowing for the formation of testable predictions about animal behavior and neural activity. The framework has been designed around the principle of flexibility, such that many experimental parameters in a decision making paradigm can be easily defined and modified. Here we demonstrate the capabilities of CBGTPy across a range of single and multi-choice tasks, highlighting the ease of set up and the biologically realistic behavior that it produces. We show that CBGTPy is extensible enough to apply to a range of experimental protocols and to allow for the implementation of model extensions with minimal developmental effort.https://doi.org/10.1371/journal.pone.0310367 |
| spellingShingle | Matthew Clapp Jyotika Bahuguna Cristina Giossi Jonathan E Rubin Timothy Verstynen Catalina Vich CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making. PLoS ONE |
| title | CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making. |
| title_full | CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making. |
| title_fullStr | CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making. |
| title_full_unstemmed | CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making. |
| title_short | CBGTPy: An extensible cortico-basal ganglia-thalamic framework for modeling biological decision making. |
| title_sort | cbgtpy an extensible cortico basal ganglia thalamic framework for modeling biological decision making |
| url | https://doi.org/10.1371/journal.pone.0310367 |
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