Clinical Outcome of Eradication Therapy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to H. pylori Infection Status
Background. To evaluate the long-term outcome of H. pylori eradication therapy for gastric MALT lymphoma according to the presence of H. pylori infection. Methods. We retrospectively reviewed the medical records of patients between January 2001 and June 2014. The clinicopathologic characteristics an...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/6794848 |
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| author | Ju Seok Kim Sun Hyung Kang Hee Seok Moon Jae Kyu Sung Hyun Yong Jeong |
| author_facet | Ju Seok Kim Sun Hyung Kang Hee Seok Moon Jae Kyu Sung Hyun Yong Jeong |
| author_sort | Ju Seok Kim |
| collection | DOAJ |
| description | Background. To evaluate the long-term outcome of H. pylori eradication therapy for gastric MALT lymphoma according to the presence of H. pylori infection. Methods. We retrospectively reviewed the medical records of patients between January 2001 and June 2014. The clinicopathologic characteristics and clinical outcomes were compared between H. pylori-positive and H. pylori-negative gastric MALT lymphoma groups. Results. Fifty-four patients were enrolled: 12 H. pylori-negative and 42 H. pylori-positive patients. The tumor was located more frequently in both the proximal and distal parts of the stomach (P=0.001), and the percentage of multiple lesions was significantly greater in the H. pylori-negative group (P=0.046). Forty-seven patients received initial eradication therapy, and 85% (35/41) of H. pylori-positive patients and 50% (3/6) of H. pylori-negative patients achieved complete remission after eradication therapy. The presence of multiple lesions was a predictive factor for unresponsiveness to H. pylori eradication (P=0.024). The efficacy of eradication therapy (P=0.133), complete remission (CR) maintenance period, and relapse after eradication therapy were not significantly different between the two groups. Conclusions. H. pylori eradication therapy could be an effective first-line treatment for localized H. pylori-negative gastric MALT lymphoma, especially for single lesions. |
| format | Article |
| id | doaj-art-696019f4fac3493d92de993e6de10b33 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-696019f4fac3493d92de993e6de10b332025-02-03T01:12:19ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/67948486794848Clinical Outcome of Eradication Therapy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to H. pylori Infection StatusJu Seok Kim0Sun Hyung Kang1Hee Seok Moon2Jae Kyu Sung3Hyun Yong Jeong4Division of Gastroenterology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of KoreaDivision of Gastroenterology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of KoreaBackground. To evaluate the long-term outcome of H. pylori eradication therapy for gastric MALT lymphoma according to the presence of H. pylori infection. Methods. We retrospectively reviewed the medical records of patients between January 2001 and June 2014. The clinicopathologic characteristics and clinical outcomes were compared between H. pylori-positive and H. pylori-negative gastric MALT lymphoma groups. Results. Fifty-four patients were enrolled: 12 H. pylori-negative and 42 H. pylori-positive patients. The tumor was located more frequently in both the proximal and distal parts of the stomach (P=0.001), and the percentage of multiple lesions was significantly greater in the H. pylori-negative group (P=0.046). Forty-seven patients received initial eradication therapy, and 85% (35/41) of H. pylori-positive patients and 50% (3/6) of H. pylori-negative patients achieved complete remission after eradication therapy. The presence of multiple lesions was a predictive factor for unresponsiveness to H. pylori eradication (P=0.024). The efficacy of eradication therapy (P=0.133), complete remission (CR) maintenance period, and relapse after eradication therapy were not significantly different between the two groups. Conclusions. H. pylori eradication therapy could be an effective first-line treatment for localized H. pylori-negative gastric MALT lymphoma, especially for single lesions.http://dx.doi.org/10.1155/2016/6794848 |
| spellingShingle | Ju Seok Kim Sun Hyung Kang Hee Seok Moon Jae Kyu Sung Hyun Yong Jeong Clinical Outcome of Eradication Therapy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to H. pylori Infection Status Gastroenterology Research and Practice |
| title | Clinical Outcome of Eradication Therapy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to H. pylori Infection Status |
| title_full | Clinical Outcome of Eradication Therapy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to H. pylori Infection Status |
| title_fullStr | Clinical Outcome of Eradication Therapy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to H. pylori Infection Status |
| title_full_unstemmed | Clinical Outcome of Eradication Therapy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to H. pylori Infection Status |
| title_short | Clinical Outcome of Eradication Therapy for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to H. pylori Infection Status |
| title_sort | clinical outcome of eradication therapy for gastric mucosa associated lymphoid tissue lymphoma according to h pylori infection status |
| url | http://dx.doi.org/10.1155/2016/6794848 |
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