Influence of multimodal low-opioid anesthesia on the dynamics of аnnexin V in blood plasma during cardiac surgery
The aim – to analyze the effect of anesthesia on the dynamics of аnnexin V during coronary artery bypass grafting with сardiopulmonary bypass (CPB), and the dependence of direct clinical results on the expression of аnnexin V. Materials and methods. The study included 30 patients with coronary he...
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| Format: | Article |
| Language: | English |
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TOV Chetverta Khvylia
2020-12-01
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| Series: | Кардіохірургія та інтервенційна кардіологія |
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| Online Access: | http://www.csic.com.ua/images/pdf/2020/4-2020/influence-multimodal-low-opioid-anesthesia-dynamics-nnexin-V-blood-plasma-during-cardiac-surgery.pdf |
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| author | S.R. Maruniak O.A. Loskutov O.M. Druzhyna I.R. Malish N.V. Korotchuk |
| author_facet | S.R. Maruniak O.A. Loskutov O.M. Druzhyna I.R. Malish N.V. Korotchuk |
| author_sort | S.R. Maruniak |
| collection | DOAJ |
| description | The aim – to analyze the effect of anesthesia on the dynamics of аnnexin V during coronary artery bypass grafting with сardiopulmonary bypass (CPB), and the dependence of direct clinical results on the expression of аnnexin V.
Materials and methods. The study included 30 patients with coronary heart disease who underwent coronary artery bypass grafting with application of 2–3 aortocoronary anastomoses with CPB. According to the anesthetic management, all patients were divided into two groups: the first group (13 patients) – low opioid anesthetic scheme; control group (17 patients) – a standard scheme of anesthetic management. The determination of the level of аnnexin V in the blood was carried out before CPB and after bringing the sternum by enzyme-linked immunosorbent assay.
Results. The low-opioid scheme of anesthetic management was associated with significantly (by 1.5 times) lower level of аnnexin V and by 28.38 % lower level of interleukin-6 at the end of the surgery as compared to the standard scheme. A significant negative correlation (r = –0.117, p = 0.523) was found between the levels of аnnexin V and interleukin-6. One-way analysis of variance showed that patients who had low cardiac output syndrome in the postoperative period had a significantly higher level of аnnexin V after CPB (p = 0.001).
Conclusions. The use of multimodal low-opioid anesthesia is characterized by relative safety, a sufficient level of analgesia and lower level of аnnexin V compared to the control group. |
| format | Article |
| id | doaj-art-6952ba611f27410e82131aae6f1ed0aa |
| institution | Kabale University |
| issn | 2305-3127 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | TOV Chetverta Khvylia |
| record_format | Article |
| series | Кардіохірургія та інтервенційна кардіологія |
| spelling | doaj-art-6952ba611f27410e82131aae6f1ed0aa2025-02-02T15:56:36ZengTOV Chetverta KhvyliaКардіохірургія та інтервенційна кардіологія2305-31272020-12-014202810.31928/2305-3127-2020.4.2028Influence of multimodal low-opioid anesthesia on the dynamics of аnnexin V in blood plasma during cardiac surgeryS.R. Maruniak0O.A. Loskutov1O.M. Druzhyna2I.R. Malish3N.V. Korotchuk4Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine, Heart Institute, Ministry of Health of Ukraine, Kyiv, UkraineShupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine, Heart Institute, Ministry of Health of Ukraine, Kyiv, UkraineShupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine, Heart Institute, Ministry of Health of Ukraine, Kyiv, UkraineShupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine, Kyiv City Clinical Hospital for Emergency Medical Care, Kyiv, UkraineHeart Institute, Ministry of Health of Ukraine, Kyiv, UkraineThe aim – to analyze the effect of anesthesia on the dynamics of аnnexin V during coronary artery bypass grafting with сardiopulmonary bypass (CPB), and the dependence of direct clinical results on the expression of аnnexin V. Materials and methods. The study included 30 patients with coronary heart disease who underwent coronary artery bypass grafting with application of 2–3 aortocoronary anastomoses with CPB. According to the anesthetic management, all patients were divided into two groups: the first group (13 patients) – low opioid anesthetic scheme; control group (17 patients) – a standard scheme of anesthetic management. The determination of the level of аnnexin V in the blood was carried out before CPB and after bringing the sternum by enzyme-linked immunosorbent assay. Results. The low-opioid scheme of anesthetic management was associated with significantly (by 1.5 times) lower level of аnnexin V and by 28.38 % lower level of interleukin-6 at the end of the surgery as compared to the standard scheme. A significant negative correlation (r = –0.117, p = 0.523) was found between the levels of аnnexin V and interleukin-6. One-way analysis of variance showed that patients who had low cardiac output syndrome in the postoperative period had a significantly higher level of аnnexin V after CPB (p = 0.001). Conclusions. The use of multimodal low-opioid anesthesia is characterized by relative safety, a sufficient level of analgesia and lower level of аnnexin V compared to the control group.http://www.csic.com.ua/images/pdf/2020/4-2020/influence-multimodal-low-opioid-anesthesia-dynamics-nnexin-V-blood-plasma-during-cardiac-surgery.pdfcoronary artery bypass graftinglow-opioid anesthesiaapoptosisаnnexin vinterleukin-6 |
| spellingShingle | S.R. Maruniak O.A. Loskutov O.M. Druzhyna I.R. Malish N.V. Korotchuk Influence of multimodal low-opioid anesthesia on the dynamics of аnnexin V in blood plasma during cardiac surgery Кардіохірургія та інтервенційна кардіологія coronary artery bypass grafting low-opioid anesthesia apoptosis аnnexin v interleukin-6 |
| title | Influence of multimodal low-opioid anesthesia on the dynamics of аnnexin V in blood plasma during cardiac surgery |
| title_full | Influence of multimodal low-opioid anesthesia on the dynamics of аnnexin V in blood plasma during cardiac surgery |
| title_fullStr | Influence of multimodal low-opioid anesthesia on the dynamics of аnnexin V in blood plasma during cardiac surgery |
| title_full_unstemmed | Influence of multimodal low-opioid anesthesia on the dynamics of аnnexin V in blood plasma during cardiac surgery |
| title_short | Influence of multimodal low-opioid anesthesia on the dynamics of аnnexin V in blood plasma during cardiac surgery |
| title_sort | influence of multimodal low opioid anesthesia on the dynamics of аnnexin v in blood plasma during cardiac surgery |
| topic | coronary artery bypass grafting low-opioid anesthesia apoptosis аnnexin v interleukin-6 |
| url | http://www.csic.com.ua/images/pdf/2020/4-2020/influence-multimodal-low-opioid-anesthesia-dynamics-nnexin-V-blood-plasma-during-cardiac-surgery.pdf |
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