Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study
Background Ankylosing spondylitis (AS) is characterized by inflammation and osteoblastic changes in the sacroiliac joint. As a potential imaging method for the early assessment of AS, positron emission tomography (PET) can quantify systemic disease activity, which is conducive to monitoring the prog...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-08-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/15353508241270405 |
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| author | Shibo Guo MD Zhehao Lyu PhD Chunyu Duan MD Hui Wang PhD Peng Xu MD Wei Han BD Peng Fu PhD |
| author_facet | Shibo Guo MD Zhehao Lyu PhD Chunyu Duan MD Hui Wang PhD Peng Xu MD Wei Han BD Peng Fu PhD |
| author_sort | Shibo Guo MD |
| collection | DOAJ |
| description | Background Ankylosing spondylitis (AS) is characterized by inflammation and osteoblastic changes in the sacroiliac joint. As a potential imaging method for the early assessment of AS, positron emission tomography (PET) can quantify systemic disease activity, which is conducive to monitoring the progression of disease activity and assisting in evaluating the efficacy of the treatment. Objective The study was to evaluate the diagnostic value of aluminium-[ 18 F]fuoride(Al 18 F)-labelled fibroblast activation protein inhibitor (FAPI) PET/computed tomography (CT) in AS and to investigate its ability to assess disease activity during the development of AS. Material and Methods Twenty AS participants who met the Assessment of SpondyloArthritis international Society criteria and were in an active disease stage were included in this study from May 2022 to April 2023. Sixteen healthy controls were also inrolled. All participants underwent Al 18 F-NOTA-FAPI-04 PET/CT imaging after collecting clinical assessment and laboratory results. The correlation between positive joint count (PJC) and systemic joint standard uptake value ratio (SUVR, the mean SUV max of the 5 highest joints/SUV max of the uninvolved sacrum) on PET and clinical disease activity assessment and various laboratory tests were analyzed. Results A total of 2820 joints were observed in 20 participants (median age 34.5,[21-61]range, 15 men), with a PJC of 1300 (46.7%), and 39 positive uptakes were found in 40 sacroiliac joints (97.5%). PET/CT images revealed FAPI-04 uptake in both sacroiliac joints in 2 participants without radiographic sacroiliitis in the early stages of AS and varying degrees of uptake in the sacroiliac joints and spinal joints in the remaining participants. PJC and SUVR were positively correlated with most clinical assessments and laboratory findings ( P < .05), and SUVR of the sacroiliac joint was positively correlated with C-reactive protein (CRP) (mg/L; r = 0.498, P = .026). Conclusion Al 18 F-NOTA-FAPI-04 PET/CT was highly sensitive to systemic arthritic changes in AS participants and correlated with clinical disease activity and laboratory tests. |
| format | Article |
| id | doaj-art-6944438c21604bd38ae504e24892759f |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-6944438c21604bd38ae504e24892759f2025-02-03T00:25:01ZengSAGE PublishingMolecular Imaging1536-01212024-08-012310.1177/15353508241270405Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical StudyShibo Guo MD0Zhehao Lyu PhD1Chunyu Duan MD2Hui Wang PhD3Peng Xu MD4Wei Han BD5Peng Fu PhD6 Department of Nuclear Medicine, , Harbin, Heilongjiang Province, China Department of Nuclear Medicine, , Harbin, Heilongjiang Province, China Department of Nuclear Medicine, , Harbin, Heilongjiang Province, China Department of Rheumatology and Immunology, , Harbin, Heilongjiang Province, China Department of Nuclear Medicine, , Harbin, Heilongjiang Province, China Department of Nuclear Medicine, , Harbin, Heilongjiang Province, China Department of Nuclear Medicine, , Harbin, Heilongjiang Province, ChinaBackground Ankylosing spondylitis (AS) is characterized by inflammation and osteoblastic changes in the sacroiliac joint. As a potential imaging method for the early assessment of AS, positron emission tomography (PET) can quantify systemic disease activity, which is conducive to monitoring the progression of disease activity and assisting in evaluating the efficacy of the treatment. Objective The study was to evaluate the diagnostic value of aluminium-[ 18 F]fuoride(Al 18 F)-labelled fibroblast activation protein inhibitor (FAPI) PET/computed tomography (CT) in AS and to investigate its ability to assess disease activity during the development of AS. Material and Methods Twenty AS participants who met the Assessment of SpondyloArthritis international Society criteria and were in an active disease stage were included in this study from May 2022 to April 2023. Sixteen healthy controls were also inrolled. All participants underwent Al 18 F-NOTA-FAPI-04 PET/CT imaging after collecting clinical assessment and laboratory results. The correlation between positive joint count (PJC) and systemic joint standard uptake value ratio (SUVR, the mean SUV max of the 5 highest joints/SUV max of the uninvolved sacrum) on PET and clinical disease activity assessment and various laboratory tests were analyzed. Results A total of 2820 joints were observed in 20 participants (median age 34.5,[21-61]range, 15 men), with a PJC of 1300 (46.7%), and 39 positive uptakes were found in 40 sacroiliac joints (97.5%). PET/CT images revealed FAPI-04 uptake in both sacroiliac joints in 2 participants without radiographic sacroiliitis in the early stages of AS and varying degrees of uptake in the sacroiliac joints and spinal joints in the remaining participants. PJC and SUVR were positively correlated with most clinical assessments and laboratory findings ( P < .05), and SUVR of the sacroiliac joint was positively correlated with C-reactive protein (CRP) (mg/L; r = 0.498, P = .026). Conclusion Al 18 F-NOTA-FAPI-04 PET/CT was highly sensitive to systemic arthritic changes in AS participants and correlated with clinical disease activity and laboratory tests.https://doi.org/10.1177/15353508241270405 |
| spellingShingle | Shibo Guo MD Zhehao Lyu PhD Chunyu Duan MD Hui Wang PhD Peng Xu MD Wei Han BD Peng Fu PhD Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study Molecular Imaging |
| title | Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study |
| title_full | Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study |
| title_fullStr | Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study |
| title_full_unstemmed | Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study |
| title_short | Preliminary Exploration of AlF-NOTA-FAPI-04 PET/CT in the Management of Ankylosing Spondylitis: A Prospective Clinical Study |
| title_sort | preliminary exploration of alf nota fapi 04 pet ct in the management of ankylosing spondylitis a prospective clinical study |
| url | https://doi.org/10.1177/15353508241270405 |
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