Hypogammaglobulinemia in a Family with Crohn’s Disease
A 55-year-old woman presented with steroid refractory Crohn’s disease. In anticipation of surgical therapy, a protein electrophoresis was done and demonstrated low serum immunoglobulins. Immunoglobulin analysis showed low levels of serum immunoglobulin G, which persisted following surgical therapy d...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1996-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1996/917908 |
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| _version_ | 1832549858688368640 |
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| author | Robert Enns Guido van Rosendaal |
| author_facet | Robert Enns Guido van Rosendaal |
| author_sort | Robert Enns |
| collection | DOAJ |
| description | A 55-year-old woman presented with steroid refractory Crohn’s disease. In anticipation of surgical therapy, a protein electrophoresis was done and demonstrated low serum immunoglobulins. Immunoglobulin analysis showed low levels of serum immunoglobulin G, which persisted following surgical therapy despite a clinical remission. A diagnosis of combined variable hypogammaglobulinemia was made and her family was screened for a similar disorder. Four of the six family members known to have Crohn’s disease were discovered to have low serum immunoglobulins. The presented patient was the index case in a family who has both hypogammaglobulinemia and Crohn’s disease. Furthermore, the two disorders in this family appear to be closely linked. Future study of the association between these two disorders may enable a more clear definition of Crohn’s disease pathogenesis. |
| format | Article |
| id | doaj-art-692e08b30ba24dca826f8cf85a699264 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1996-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-692e08b30ba24dca826f8cf85a6992642025-02-03T06:08:23ZengWileyCanadian Journal of Gastroenterology0835-79001996-01-0110530430610.1155/1996/917908Hypogammaglobulinemia in a Family with Crohn’s DiseaseRobert Enns0Guido van Rosendaal1University of Calgary, Calgary, Alberta, CanadaUniversity of Calgary, Calgary, Alberta, CanadaA 55-year-old woman presented with steroid refractory Crohn’s disease. In anticipation of surgical therapy, a protein electrophoresis was done and demonstrated low serum immunoglobulins. Immunoglobulin analysis showed low levels of serum immunoglobulin G, which persisted following surgical therapy despite a clinical remission. A diagnosis of combined variable hypogammaglobulinemia was made and her family was screened for a similar disorder. Four of the six family members known to have Crohn’s disease were discovered to have low serum immunoglobulins. The presented patient was the index case in a family who has both hypogammaglobulinemia and Crohn’s disease. Furthermore, the two disorders in this family appear to be closely linked. Future study of the association between these two disorders may enable a more clear definition of Crohn’s disease pathogenesis.http://dx.doi.org/10.1155/1996/917908 |
| spellingShingle | Robert Enns Guido van Rosendaal Hypogammaglobulinemia in a Family with Crohn’s Disease Canadian Journal of Gastroenterology |
| title | Hypogammaglobulinemia in a Family with Crohn’s Disease |
| title_full | Hypogammaglobulinemia in a Family with Crohn’s Disease |
| title_fullStr | Hypogammaglobulinemia in a Family with Crohn’s Disease |
| title_full_unstemmed | Hypogammaglobulinemia in a Family with Crohn’s Disease |
| title_short | Hypogammaglobulinemia in a Family with Crohn’s Disease |
| title_sort | hypogammaglobulinemia in a family with crohn s disease |
| url | http://dx.doi.org/10.1155/1996/917908 |
| work_keys_str_mv | AT robertenns hypogammaglobulinemiainafamilywithcrohnsdisease AT guidovanrosendaal hypogammaglobulinemiainafamilywithcrohnsdisease |