Recent advances in the role of high-salt diet in anti- and pro-cancer progression
Dietary behaviors significantly influence tumor progression, with increasing focus on high-salt diets (HSD) in recent years. Traditionally, HSD has been regarded as a major risk factor for multiple health issues, including hypertension, cardiovascular disease, kidney disease, cancer, and osteoporosi...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1542157/full |
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| author | Shiwei Tang Juan Xu Ping Wan Ping Wan Ping Wan Shumen Jin Ying Zhang Ying Zhang Linting Xun Linting Xun Jinli Wang Jinli Wang Mei Luo Mei Luo Wenjie Chen Wenjie Chen Zan Zuo Zan Zuo Zan Zuo Hui Tang Hui Tang Jialong Qi Jialong Qi Jialong Qi Jialong Qi Jialong Qi |
| author_facet | Shiwei Tang Juan Xu Ping Wan Ping Wan Ping Wan Shumen Jin Ying Zhang Ying Zhang Linting Xun Linting Xun Jinli Wang Jinli Wang Mei Luo Mei Luo Wenjie Chen Wenjie Chen Zan Zuo Zan Zuo Zan Zuo Hui Tang Hui Tang Jialong Qi Jialong Qi Jialong Qi Jialong Qi Jialong Qi |
| author_sort | Shiwei Tang |
| collection | DOAJ |
| description | Dietary behaviors significantly influence tumor progression, with increasing focus on high-salt diets (HSD) in recent years. Traditionally, HSD has been regarded as a major risk factor for multiple health issues, including hypertension, cardiovascular disease, kidney disease, cancer, and osteoporosis. However, recent studies have uncovered a novel aspect of HSD, suggesting that HSD may inhibit tumor growth in specific pathological conditions by modulating the activity of immune cells that infiltrate tumors and enhancing the effectiveness of PD-1 immunotherapy. This review focused on the duel molecular mechanisms of HSD in cancer development, which are based on the tumor microenvironment, the gut microbiota, and the involvement of sodium transporter channels. The objective of this review is to explore whether HSD could be a potential future oncological therapeutic strategy under specific situation. |
| format | Article |
| id | doaj-art-6927aaa819284e10a53af56d64d39a6d |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-6927aaa819284e10a53af56d64d39a6d2025-01-29T06:46:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15421571542157Recent advances in the role of high-salt diet in anti- and pro-cancer progressionShiwei Tang0Juan Xu1Ping Wan2Ping Wan3Ping Wan4Shumen Jin5Ying Zhang6Ying Zhang7Linting Xun8Linting Xun9Jinli Wang10Jinli Wang11Mei Luo12Mei Luo13Wenjie Chen14Wenjie Chen15Zan Zuo16Zan Zuo17Zan Zuo18Hui Tang19Hui Tang20Jialong Qi21Jialong Qi22Jialong Qi23Jialong Qi24Jialong Qi25School of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Province Clinical Research Center for Senile Diseases, First People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaYunnan Institute of Food and Drug Supervision and Control, Medical Products Administration of Yunnan Province, Kuming, Yunnan, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, ChinaGuangdong-Hongkong-Macao Joint Laboratory of Respiratory Infectious Disease, Guangzhou Medical University, Guangzhou, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Provincial Key Laboratory of Clinical Virology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Digestive Endoscopy Clinical Medical Center, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated by Kunming University of Science and Technology, Kunming, Yunnan, ChinaYunnan Province Clinical Research Center for Senile Diseases, First People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaYunnan Provincial Key Laboratory of Clinical Virology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaYunnan Provincial Key Laboratory of Birth Defects and Genetic Diseases, First People’s Hospital of Yunnan Province, Kunming, Yunnan, ChinaDietary behaviors significantly influence tumor progression, with increasing focus on high-salt diets (HSD) in recent years. Traditionally, HSD has been regarded as a major risk factor for multiple health issues, including hypertension, cardiovascular disease, kidney disease, cancer, and osteoporosis. However, recent studies have uncovered a novel aspect of HSD, suggesting that HSD may inhibit tumor growth in specific pathological conditions by modulating the activity of immune cells that infiltrate tumors and enhancing the effectiveness of PD-1 immunotherapy. This review focused on the duel molecular mechanisms of HSD in cancer development, which are based on the tumor microenvironment, the gut microbiota, and the involvement of sodium transporter channels. The objective of this review is to explore whether HSD could be a potential future oncological therapeutic strategy under specific situation.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1542157/fullhigh-salt diet (HSD)immunotherapytumor microenvironment (TME)gut microbiotasodium transporter channels |
| spellingShingle | Shiwei Tang Juan Xu Ping Wan Ping Wan Ping Wan Shumen Jin Ying Zhang Ying Zhang Linting Xun Linting Xun Jinli Wang Jinli Wang Mei Luo Mei Luo Wenjie Chen Wenjie Chen Zan Zuo Zan Zuo Zan Zuo Hui Tang Hui Tang Jialong Qi Jialong Qi Jialong Qi Jialong Qi Jialong Qi Recent advances in the role of high-salt diet in anti- and pro-cancer progression Frontiers in Immunology high-salt diet (HSD) immunotherapy tumor microenvironment (TME) gut microbiota sodium transporter channels |
| title | Recent advances in the role of high-salt diet in anti- and pro-cancer progression |
| title_full | Recent advances in the role of high-salt diet in anti- and pro-cancer progression |
| title_fullStr | Recent advances in the role of high-salt diet in anti- and pro-cancer progression |
| title_full_unstemmed | Recent advances in the role of high-salt diet in anti- and pro-cancer progression |
| title_short | Recent advances in the role of high-salt diet in anti- and pro-cancer progression |
| title_sort | recent advances in the role of high salt diet in anti and pro cancer progression |
| topic | high-salt diet (HSD) immunotherapy tumor microenvironment (TME) gut microbiota sodium transporter channels |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1542157/full |
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