The atherogenic index of plasma increases the risk of incident kidney stones: a nested case–control study in Chinese adults
Objective To investigate the association between atherogenic index of plasma (AIP) and risk of incident kidney stones.Methods A nested case-control study was conducted using data from the Shanghai Kidney Stone Cohort from December 2018 to February 2023. Kidney stones were ascertained by ultrasound....
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2458757 |
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| author | Dawei Wang Feng Shi Dingguo Zhang Hui Wang Yu Zhu Jun Wang |
| author_facet | Dawei Wang Feng Shi Dingguo Zhang Hui Wang Yu Zhu Jun Wang |
| author_sort | Dawei Wang |
| collection | DOAJ |
| description | Objective To investigate the association between atherogenic index of plasma (AIP) and risk of incident kidney stones.Methods A nested case-control study was conducted using data from the Shanghai Kidney Stone Cohort from December 2018 to February 2023. Kidney stones were ascertained by ultrasound. Propensity score matching selected 2,550 patients with incident kidney stones and 5,100 controls from a total of 64,121 adults. Baseline fasting plasma samples were collected to measure the AIP, defined as the logarithm of the ratio triglycerides to high-density lipoprotein cholesterol. A multivariable conditional logistic regression model and restricted cubic spline were applied to examine the association between the AIP and the risk of incident kidney stones.Results The baseline AIP values of the incident kidney stone patients and controls were 0.98 (0.67) and 0.91 (0.65), respectively. Patients with incident kidney stones had much higher baseline AIP levels than controls (p < 0.001). Participants in the highest AIP quartile had a 29% greater risk of developing kidney stones. Moreover, each increase in the standard deviation of the AIP was associated with a 10% greater risk of nephrolithiasis. A restricted cubic spline showed a significant positive and linear correlation between the AIP and the risk of developing kidney stones (P-overall = 0.040, P-nonlinear = 0.923). These findings remained robust in sensitivity analyses.Conclusions A higher AIP is associated with a greater risk of incident kidney stones. |
| format | Article |
| id | doaj-art-69255b5d99b14d9984383cf5257a8ece |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-69255b5d99b14d9984383cf5257a8ece2025-02-05T04:03:20ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2458757The atherogenic index of plasma increases the risk of incident kidney stones: a nested case–control study in Chinese adultsDawei Wang0Feng Shi1Dingguo Zhang2Hui Wang3Yu Zhu4Jun Wang5Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCAAC East China Aviation Personnel Medical Appraisal Center, Civil Aviation Shanghai Hospital, Shanghai, ChinaDepartment of Urology, Shanghai Pudong New Area People’s Hospital, Shanghai, ChinaDepartment of Urology, Shanghai Anting Hospital, Shanghai, ChinaDepartment of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaObjective To investigate the association between atherogenic index of plasma (AIP) and risk of incident kidney stones.Methods A nested case-control study was conducted using data from the Shanghai Kidney Stone Cohort from December 2018 to February 2023. Kidney stones were ascertained by ultrasound. Propensity score matching selected 2,550 patients with incident kidney stones and 5,100 controls from a total of 64,121 adults. Baseline fasting plasma samples were collected to measure the AIP, defined as the logarithm of the ratio triglycerides to high-density lipoprotein cholesterol. A multivariable conditional logistic regression model and restricted cubic spline were applied to examine the association between the AIP and the risk of incident kidney stones.Results The baseline AIP values of the incident kidney stone patients and controls were 0.98 (0.67) and 0.91 (0.65), respectively. Patients with incident kidney stones had much higher baseline AIP levels than controls (p < 0.001). Participants in the highest AIP quartile had a 29% greater risk of developing kidney stones. Moreover, each increase in the standard deviation of the AIP was associated with a 10% greater risk of nephrolithiasis. A restricted cubic spline showed a significant positive and linear correlation between the AIP and the risk of developing kidney stones (P-overall = 0.040, P-nonlinear = 0.923). These findings remained robust in sensitivity analyses.Conclusions A higher AIP is associated with a greater risk of incident kidney stones.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2458757Kidney stonesatherogenic index of plasmanested case-control studydyslipidemia |
| spellingShingle | Dawei Wang Feng Shi Dingguo Zhang Hui Wang Yu Zhu Jun Wang The atherogenic index of plasma increases the risk of incident kidney stones: a nested case–control study in Chinese adults Renal Failure Kidney stones atherogenic index of plasma nested case-control study dyslipidemia |
| title | The atherogenic index of plasma increases the risk of incident kidney stones: a nested case–control study in Chinese adults |
| title_full | The atherogenic index of plasma increases the risk of incident kidney stones: a nested case–control study in Chinese adults |
| title_fullStr | The atherogenic index of plasma increases the risk of incident kidney stones: a nested case–control study in Chinese adults |
| title_full_unstemmed | The atherogenic index of plasma increases the risk of incident kidney stones: a nested case–control study in Chinese adults |
| title_short | The atherogenic index of plasma increases the risk of incident kidney stones: a nested case–control study in Chinese adults |
| title_sort | atherogenic index of plasma increases the risk of incident kidney stones a nested case control study in chinese adults |
| topic | Kidney stones atherogenic index of plasma nested case-control study dyslipidemia |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2458757 |
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