A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma
This is a case report of a previously undescribed 20q chromosomal deletion (del(20q)) in marginal zone lymphoma (MZL). A 54-year-old Caucasian male presented with an enlarging neck mass and multiple violaceous skin nodules over his chest. Biopsy of the neck mass and cervical lymph nodes revealed MZL...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2013/784176 |
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| author | Jason B. Kern Deiter J. Duff Jamie L. Odem Magda Esebua Lisa R. Smith Donald Doll Michael Wang |
| author_facet | Jason B. Kern Deiter J. Duff Jamie L. Odem Magda Esebua Lisa R. Smith Donald Doll Michael Wang |
| author_sort | Jason B. Kern |
| collection | DOAJ |
| description | This is a case report of a previously undescribed 20q chromosomal deletion (del(20q)) in marginal zone lymphoma (MZL). A 54-year-old Caucasian male presented with an enlarging neck mass and multiple violaceous skin nodules over his chest. Biopsy of the neck mass and cervical lymph nodes revealed MZL. Cytogenetic evaluation of both lymph node and bone marrow tissue revealed del(20q). This was an unexpected finding, as del(20q) is associated with myelodysplastic syndromes and myeloproliferative neoplasms and rarely seen in diffuse large B-cell lymphoma, follicular lymphoma, and T-cell lymphoma, but has not previously been described in MZL. We describe the case presentation and histologic findings and discuss the significance of this novel finding. |
| format | Article |
| id | doaj-art-69229298bc424e7aadd117f0dc7e5815 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-69229298bc424e7aadd117f0dc7e58152025-02-03T06:06:15ZengWileyCase Reports in Pathology2090-67812090-679X2013-01-01201310.1155/2013/784176784176A Novel del(20q) in Aggressive Nodal Marginal Zone LymphomaJason B. Kern0Deiter J. Duff1Jamie L. Odem2Magda Esebua3Lisa R. Smith4Donald Doll5Michael Wang6Department of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO 65203, USADepartment of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO 65203, USADepartment of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO 65203, USADepartment of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO 65203, USADepartment of Cytogenetics, Sonora Quest Laboratories, Tempe, AZ 86281, USADivision of Hematology and Medical Oncology, Ellis Fischel Cancer Center, School of Medicine, University of Missouri, Columbia, MO 65203, USADepartment of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO 65203, USAThis is a case report of a previously undescribed 20q chromosomal deletion (del(20q)) in marginal zone lymphoma (MZL). A 54-year-old Caucasian male presented with an enlarging neck mass and multiple violaceous skin nodules over his chest. Biopsy of the neck mass and cervical lymph nodes revealed MZL. Cytogenetic evaluation of both lymph node and bone marrow tissue revealed del(20q). This was an unexpected finding, as del(20q) is associated with myelodysplastic syndromes and myeloproliferative neoplasms and rarely seen in diffuse large B-cell lymphoma, follicular lymphoma, and T-cell lymphoma, but has not previously been described in MZL. We describe the case presentation and histologic findings and discuss the significance of this novel finding.http://dx.doi.org/10.1155/2013/784176 |
| spellingShingle | Jason B. Kern Deiter J. Duff Jamie L. Odem Magda Esebua Lisa R. Smith Donald Doll Michael Wang A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma Case Reports in Pathology |
| title | A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma |
| title_full | A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma |
| title_fullStr | A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma |
| title_full_unstemmed | A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma |
| title_short | A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma |
| title_sort | novel del 20q in aggressive nodal marginal zone lymphoma |
| url | http://dx.doi.org/10.1155/2013/784176 |
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