Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a group of immune-mediated conditions. Immune activity is varied by age and gender. The present study is aimed at investigating the effect of age and gender on the positive rates of anti-Saccharomyces cerevisiae antibodies (ASCA), anti-neutrophil cytoplasmic antib...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/4963641 |
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| author | Qingquan Chen Shirong Huang Yue Wu Shuyu Zhang Qicai Liu Min Chen |
| author_facet | Qingquan Chen Shirong Huang Yue Wu Shuyu Zhang Qicai Liu Min Chen |
| author_sort | Qingquan Chen |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a group of immune-mediated conditions. Immune activity is varied by age and gender. The present study is aimed at investigating the effect of age and gender on the positive rates of anti-Saccharomyces cerevisiae antibodies (ASCA), anti-neutrophil cytoplasmic antibodies (ANCA), anti-intestinal goblet cell antibodies (GAB), and antibodies to exocrine pancreas (PAB) in IBD patients. A total of 1871 hospitalized patients with confirmed IBD were included in this study. Sera were obtained from each subject for antibody measurement by indirect immunofluorescence assay. The positive rates of ANCA IgG and IgA were higher in female patients than those in male patients (P<0.001) while the positive rate of PAB IgG was just reversed (P<0.001). Moreover, the median ages of patients with positive ANCA IgG and IgA were higher than patients with negative antibodies (P=0.0019 and P=0.0110, respectively), while the median ages of patients with positive PAB IgG and IgA were significantly lower than patients with negative PAB (P<0.0001). The serum levels of ANCA IgG and IgA were potentiated in old female patients, while serum PAB IgG was easy to be detected in the young male patients with IBD. |
| format | Article |
| id | doaj-art-690ebabcfeb845d1b89f3e87b293b450 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-690ebabcfeb845d1b89f3e87b293b4502025-02-03T01:25:18ZengWileyGastroenterology Research and Practice1687-61211687-630X2021-01-01202110.1155/2021/49636414963641Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel DiseaseQingquan Chen0Shirong Huang1Yue Wu2Shuyu Zhang3Qicai Liu4Min Chen5Department of Laboratory Medicine, Fujian Medical University, Fuzhou, Fujian 350004, ChinaDepartment of Laboratory Medicine, Fujian Medical University, Fuzhou, Fujian 350004, ChinaDepartment of Laboratory Medicine, Fujian Medical University, Fuzhou, Fujian 350004, ChinaDepartment of Laboratory Medicine, Fujian Medical University, Fuzhou, Fujian 350004, ChinaCenter for Reproductive Medicine, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350004, ChinaDepartment of Laboratory Medicine, Fujian Medical University, Fuzhou, Fujian 350004, ChinaInflammatory bowel disease (IBD) is a group of immune-mediated conditions. Immune activity is varied by age and gender. The present study is aimed at investigating the effect of age and gender on the positive rates of anti-Saccharomyces cerevisiae antibodies (ASCA), anti-neutrophil cytoplasmic antibodies (ANCA), anti-intestinal goblet cell antibodies (GAB), and antibodies to exocrine pancreas (PAB) in IBD patients. A total of 1871 hospitalized patients with confirmed IBD were included in this study. Sera were obtained from each subject for antibody measurement by indirect immunofluorescence assay. The positive rates of ANCA IgG and IgA were higher in female patients than those in male patients (P<0.001) while the positive rate of PAB IgG was just reversed (P<0.001). Moreover, the median ages of patients with positive ANCA IgG and IgA were higher than patients with negative antibodies (P=0.0019 and P=0.0110, respectively), while the median ages of patients with positive PAB IgG and IgA were significantly lower than patients with negative PAB (P<0.0001). The serum levels of ANCA IgG and IgA were potentiated in old female patients, while serum PAB IgG was easy to be detected in the young male patients with IBD.http://dx.doi.org/10.1155/2021/4963641 |
| spellingShingle | Qingquan Chen Shirong Huang Yue Wu Shuyu Zhang Qicai Liu Min Chen Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel Disease Gastroenterology Research and Practice |
| title | Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel Disease |
| title_full | Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel Disease |
| title_fullStr | Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel Disease |
| title_full_unstemmed | Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel Disease |
| title_short | Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel Disease |
| title_sort | age and gender affecting the positive rates of serum pab and anca in patients with inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2021/4963641 |
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