Inhibitory effect of interferon-beta on mouse spleen-derived mast cells
Preparations of murine recombinant interferon (Mu-rIFN)-alpha, -beta and -gamma were assessed for their influence on in vitro growth of mast cells from normal mouse spleen cells (Sp C). Mast cell growth was inhibited by Mu-rIFNs when Sp C were exposed throughout the entire culture period to Mu-rIFNs...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1993-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S096293519300033X |
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| _version_ | 1832565512808169472 |
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| author | S. Konno M. Adachi K. Asano K. Okamoto T. Takahashi |
| author_facet | S. Konno M. Adachi K. Asano K. Okamoto T. Takahashi |
| author_sort | S. Konno |
| collection | DOAJ |
| description | Preparations of murine recombinant interferon (Mu-rIFN)-alpha, -beta and -gamma were assessed for their influence on in vitro growth of mast cells from normal mouse spleen cells (Sp C). Mast cell growth was inhibited by Mu-rIFNs when Sp C were exposed throughout the entire culture period to Mu-rIFNs. The most potent inhibitor of mast cell growth was Mu-rIFN-γ, followed by Mu-rIFN-β; Mu-rlFN-α had little effect. When added to IC-2 cells, clonal mast cell progenitor, both Mu-rlFN-β and −γ), significantly inhibited proliferative response of the target cells. The suppressive effect of Mu-rIFNs on IC-2 cells was selectively abolished by monoclonal antibodies against Mu-rIFN-β and −γ. |
| format | Article |
| id | doaj-art-690dd15906cc41388258537db53f25c2 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-690dd15906cc41388258537db53f25c22025-02-03T01:07:29ZengWileyMediators of Inflammation0962-93511466-18611993-01-012324324610.1155/S096293519300033XInhibitory effect of interferon-beta on mouse spleen-derived mast cellsS. Konno0M. Adachi1K. Asano2K. Okamoto3T. Takahashi4First Department of Internal Medicine, School of Medicine, Showa University, Hatanodai, Shinagawa-ku, Tokyo 142, JapanFirst Department of Internal Medicine, School of Medicine, Showa University, Hatanodai, Shinagawa-ku, Tokyo 142, JapanDepartment of Medical Biology, School of Medicine, Showa University, Hatanodai, Shinagawa-ku, Tokyo 142, JapanDepartment of Medical Biology, School of Medicine, Showa University, Hatanodai, Shinagawa-ku, Tokyo 142, JapanFirst Department of Internal Medicine, School of Medicine, Showa University, Hatanodai, Shinagawa-ku, Tokyo 142, JapanPreparations of murine recombinant interferon (Mu-rIFN)-alpha, -beta and -gamma were assessed for their influence on in vitro growth of mast cells from normal mouse spleen cells (Sp C). Mast cell growth was inhibited by Mu-rIFNs when Sp C were exposed throughout the entire culture period to Mu-rIFNs. The most potent inhibitor of mast cell growth was Mu-rIFN-γ, followed by Mu-rIFN-β; Mu-rlFN-α had little effect. When added to IC-2 cells, clonal mast cell progenitor, both Mu-rlFN-β and −γ), significantly inhibited proliferative response of the target cells. The suppressive effect of Mu-rIFNs on IC-2 cells was selectively abolished by monoclonal antibodies against Mu-rIFN-β and −γ.http://dx.doi.org/10.1155/S096293519300033X |
| spellingShingle | S. Konno M. Adachi K. Asano K. Okamoto T. Takahashi Inhibitory effect of interferon-beta on mouse spleen-derived mast cells Mediators of Inflammation |
| title | Inhibitory effect of interferon-beta on mouse spleen-derived mast cells |
| title_full | Inhibitory effect of interferon-beta on mouse spleen-derived mast cells |
| title_fullStr | Inhibitory effect of interferon-beta on mouse spleen-derived mast cells |
| title_full_unstemmed | Inhibitory effect of interferon-beta on mouse spleen-derived mast cells |
| title_short | Inhibitory effect of interferon-beta on mouse spleen-derived mast cells |
| title_sort | inhibitory effect of interferon beta on mouse spleen derived mast cells |
| url | http://dx.doi.org/10.1155/S096293519300033X |
| work_keys_str_mv | AT skonno inhibitoryeffectofinterferonbetaonmousespleenderivedmastcells AT madachi inhibitoryeffectofinterferonbetaonmousespleenderivedmastcells AT kasano inhibitoryeffectofinterferonbetaonmousespleenderivedmastcells AT kokamoto inhibitoryeffectofinterferonbetaonmousespleenderivedmastcells AT ttakahashi inhibitoryeffectofinterferonbetaonmousespleenderivedmastcells |