Water-soluble vidarabine derivatives alleviate catecholamine-induced heart failure and arrhythmia without impairing cardiac function in mice.

Water-soluble vidarabine derivatives alleviate catecholamine-induced heart failure and arrhythmia without impairing cardiac function in mice.

The worldwide standard guideline for treating heart failure (HF) is inhibition of the patients' chronically enhanced sympathetic nervous system activity. However, despite gains in the treatment of HF with angiotensin and β-adrenergic receptor (β-AR) blockers, some patients do not tolerate β-AR...

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Main Authors: Kenji Suita, Yoshio Hayakawa, Yujiro Hoshino, Wenqian Cai, Reiko Kurotani, Yoshiki Ohnuki, Yasumasa Mototani, Yoshihiro Ishikawa, Satoshi Okumura
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0330507
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