A Kinetic Model of Antigen‐Dependent IgG Oligomerization and Complement Binding

A Kinetic Model of Antigen‐Dependent IgG Oligomerization and Complement Binding

The classical complement pathway (CCP) is an essential part of the immune system, activated when complement protein C1 binds to IgG antibody oligomers on the surface of pathogens, infected or malignant cells, culminating in the formation of the membrane attack complex and subsequent cell lysis. IgG...

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Bibliographic Details
Main Authors: Jürgen Strasser, Nikolaus Frischauf, Lukas Schustereder, Andreas Karner, Sieto Bosgra, Aran F. Labrijn, Frank J. Beurskens, Johannes Preiner
Format: Article
Language:English
Published: Wiley-VCH 2025-07-01
Series:Small Science
Subjects:
C1
classical complement pathway
complement mediated
IgG hexamers
IgG oligomerization
IgG subclasses
Online Access:https://doi.org/10.1002/smsc.202500149
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