A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties
The vascular endothelial growth factor (VEGF) is known as one of the main promoter of angiogenesis - the process of blood vessel formation. Angiogenesis has been recognized as a key stage for cancer development and metastasis. In this paper, we propose a structural model of the main molecular pathwa...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2012-11-01
|
| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.167 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590120457338880 |
|---|---|
| author | Floriane Lignet Vincent Calvez Emmanuel Grenier Benjamin Ribba |
| author_facet | Floriane Lignet Vincent Calvez Emmanuel Grenier Benjamin Ribba |
| author_sort | Floriane Lignet |
| collection | DOAJ |
| description | The vascular endothelial growth factor (VEGF) is known as one of the main promoter of angiogenesis - the process of blood vessel formation. Angiogenesis has been recognized as a key stage for cancer development and metastasis. In this paper, we propose a structural model of the main molecular pathways involved in the endothelial cells response to VEGF stimuli. The model, built on qualitative information from knowledge databases, is composed of 38 ordinary differential equations with 78 parameters and focuses on the signalling driving endothelial cell proliferation, migration and resistance to apoptosis. Following a VEGF stimulus, the model predicts an increase of proliferation and migration capability, and a decrease in the apoptosis activity. Model simulations and sensitivity analysis highlight the emergence of robustness and redundancy properties of the pathway. If further calibrated and validated, this model could serve as tool to analyse and formulate new hypothesis on th e VEGF signalling cascade and its role in cancer development and treatment. |
| format | Article |
| id | doaj-art-68ed2a050eac490ea67aa8babedbcea8 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2012-11-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-68ed2a050eac490ea67aa8babedbcea82025-01-24T02:25:25ZengAIMS PressMathematical Biosciences and Engineering1551-00182012-11-0110116718410.3934/mbe.2013.10.167A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy propertiesFloriane Lignet0Vincent Calvez1Emmanuel Grenier2Benjamin Ribba3INRIA, Project-team NUMED, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69007 Lyon Cedex 07INRIA, Project-team NUMED, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69007 Lyon Cedex 07INRIA, Project-team NUMED, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69007 Lyon Cedex 07INRIA, Project-team NUMED, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69007 Lyon Cedex 07The vascular endothelial growth factor (VEGF) is known as one of the main promoter of angiogenesis - the process of blood vessel formation. Angiogenesis has been recognized as a key stage for cancer development and metastasis. In this paper, we propose a structural model of the main molecular pathways involved in the endothelial cells response to VEGF stimuli. The model, built on qualitative information from knowledge databases, is composed of 38 ordinary differential equations with 78 parameters and focuses on the signalling driving endothelial cell proliferation, migration and resistance to apoptosis. Following a VEGF stimulus, the model predicts an increase of proliferation and migration capability, and a decrease in the apoptosis activity. Model simulations and sensitivity analysis highlight the emergence of robustness and redundancy properties of the pathway. If further calibrated and validated, this model could serve as tool to analyse and formulate new hypothesis on th e VEGF signalling cascade and its role in cancer development and treatment.https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.167vascular endothelial growth factor (vegf) signalling.networksmolecular reactionsordinary differential equationskinetics in biochemical problemssystems biology |
| spellingShingle | Floriane Lignet Vincent Calvez Emmanuel Grenier Benjamin Ribba A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties Mathematical Biosciences and Engineering vascular endothelial growth factor (vegf) signalling. networks molecular reactions ordinary differential equations kinetics in biochemical problems systems biology |
| title | A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties |
| title_full | A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties |
| title_fullStr | A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties |
| title_full_unstemmed | A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties |
| title_short | A structural model of the VEGF signalling pathway: Emergence of robustness and redundancy properties |
| title_sort | structural model of the vegf signalling pathway emergence of robustness and redundancy properties |
| topic | vascular endothelial growth factor (vegf) signalling. networks molecular reactions ordinary differential equations kinetics in biochemical problems systems biology |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.167 |
| work_keys_str_mv | AT florianelignet astructuralmodelofthevegfsignallingpathwayemergenceofrobustnessandredundancyproperties AT vincentcalvez astructuralmodelofthevegfsignallingpathwayemergenceofrobustnessandredundancyproperties AT emmanuelgrenier astructuralmodelofthevegfsignallingpathwayemergenceofrobustnessandredundancyproperties AT benjaminribba astructuralmodelofthevegfsignallingpathwayemergenceofrobustnessandredundancyproperties AT florianelignet structuralmodelofthevegfsignallingpathwayemergenceofrobustnessandredundancyproperties AT vincentcalvez structuralmodelofthevegfsignallingpathwayemergenceofrobustnessandredundancyproperties AT emmanuelgrenier structuralmodelofthevegfsignallingpathwayemergenceofrobustnessandredundancyproperties AT benjaminribba structuralmodelofthevegfsignallingpathwayemergenceofrobustnessandredundancyproperties |