Kinetics of the amino acid uptake tracer O-(2-[18F]fluoroethyl)-L-tyrosine (FET) in human brain

Kinetics of the amino acid uptake tracer O-(2-[18F]fluoroethyl)-L-tyrosine (FET) in human brain

Abstract Background The large neutral amino acid [18F]fluoroethoxy-L-tyrosine ([18F]FET) is a popular tracer for detection and staging of intracranial tumors by positron emission tomography (PET). While its high tumoral uptake reflects over-expression of the L-type amino acid transporter (LAT1), the...

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Bibliographic Details
Main Authors: Korbinian Krieger, Thomas Pyka, Clemens Mingels, Hasan Sari, Albert Gjedde, Axel Rominger, Paul Cumming
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:EJNMMI Research
Subjects:
Positron emission tomography (PET)
[18F]Fluoroethoxy-L-tyrosine (FET)
Physiological
Brain
Large neutral amino acids
L-type amino acid transporter
Online Access:https://doi.org/10.1186/s13550-025-01279-7
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