Secondary bilateral synchronization of interictal EEG discharges in focal epilepsy: prevalence and associated factors
BackgroundEpilepsy is commonly categorized based on etiology, treatment, and prognosis. Misclassification can occur due to the presence of interictal secondary bilateral synchronization (SBS) discharges seen on an electroencephalogram (EEG), misleading the classification process.ObjectiveTo examine...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1446471/full |
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| author | Polina Specktor Ronen Spierer Mark Katson Moshe Herskovitz Moshe Herskovitz |
| author_facet | Polina Specktor Ronen Spierer Mark Katson Moshe Herskovitz Moshe Herskovitz |
| author_sort | Polina Specktor |
| collection | DOAJ |
| description | BackgroundEpilepsy is commonly categorized based on etiology, treatment, and prognosis. Misclassification can occur due to the presence of interictal secondary bilateral synchronization (SBS) discharges seen on an electroencephalogram (EEG), misleading the classification process.ObjectiveTo examine the prevalence of interictal SBS discharges in patients with focal epilepsy and to identify predictors of these discharges.DesignRetrospective analysis of patients who underwent long-term video EEG monitoring (LTVEM) from August 2001 to May 2014.MethodsWe included patients with focal epilepsy. The patients were divided into two groups based on whether or not they had SBS discharges.ResultsWe found 1,017 patients who underwent LTVEM. Of the 221 patients included in the final analysis, 36 (16%) exhibited SBS discharges. Patients in the SBS group were younger and had an earlier onset age of epilepsy. They also had higher rates of unclear seizure onset zone and focal to bilateral tonic–clonic seizures. In the binary logistic regression analysis, young onset age of epilepsy was the only significant factor.ConclusionThe prevalence of SBS discharges in focal epilepsy is relatively high (16%), emphasizing the importance of cautious interpretation of interictal EEG in epilepsy classification. Young age of disease onset is associated with higher rates of SBS. |
| format | Article |
| id | doaj-art-68dd0c5722194206985dde96773f9274 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-68dd0c5722194206985dde96773f92742025-02-04T05:28:13ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-02-011610.3389/fneur.2025.14464711446471Secondary bilateral synchronization of interictal EEG discharges in focal epilepsy: prevalence and associated factorsPolina Specktor0Ronen Spierer1Mark Katson2Moshe Herskovitz3Moshe Herskovitz4Department of Neurology, Carmel Medical Center, Haifa, IsraelRappaport Faculty of Medicine, Technion Institute of Technology, Haifa, IsraelDepartment of Neurology, Rambam Health Care Center, Haifa, IsraelRappaport Faculty of Medicine, Technion Institute of Technology, Haifa, IsraelDepartment of Neurology, Rambam Health Care Center, Haifa, IsraelBackgroundEpilepsy is commonly categorized based on etiology, treatment, and prognosis. Misclassification can occur due to the presence of interictal secondary bilateral synchronization (SBS) discharges seen on an electroencephalogram (EEG), misleading the classification process.ObjectiveTo examine the prevalence of interictal SBS discharges in patients with focal epilepsy and to identify predictors of these discharges.DesignRetrospective analysis of patients who underwent long-term video EEG monitoring (LTVEM) from August 2001 to May 2014.MethodsWe included patients with focal epilepsy. The patients were divided into two groups based on whether or not they had SBS discharges.ResultsWe found 1,017 patients who underwent LTVEM. Of the 221 patients included in the final analysis, 36 (16%) exhibited SBS discharges. Patients in the SBS group were younger and had an earlier onset age of epilepsy. They also had higher rates of unclear seizure onset zone and focal to bilateral tonic–clonic seizures. In the binary logistic regression analysis, young onset age of epilepsy was the only significant factor.ConclusionThe prevalence of SBS discharges in focal epilepsy is relatively high (16%), emphasizing the importance of cautious interpretation of interictal EEG in epilepsy classification. Young age of disease onset is associated with higher rates of SBS.https://www.frontiersin.org/articles/10.3389/fneur.2025.1446471/fullsecondary bilateral synchronyepilepsyinterictalEEGepileptiform discharges |
| spellingShingle | Polina Specktor Ronen Spierer Mark Katson Moshe Herskovitz Moshe Herskovitz Secondary bilateral synchronization of interictal EEG discharges in focal epilepsy: prevalence and associated factors Frontiers in Neurology secondary bilateral synchrony epilepsy interictal EEG epileptiform discharges |
| title | Secondary bilateral synchronization of interictal EEG discharges in focal epilepsy: prevalence and associated factors |
| title_full | Secondary bilateral synchronization of interictal EEG discharges in focal epilepsy: prevalence and associated factors |
| title_fullStr | Secondary bilateral synchronization of interictal EEG discharges in focal epilepsy: prevalence and associated factors |
| title_full_unstemmed | Secondary bilateral synchronization of interictal EEG discharges in focal epilepsy: prevalence and associated factors |
| title_short | Secondary bilateral synchronization of interictal EEG discharges in focal epilepsy: prevalence and associated factors |
| title_sort | secondary bilateral synchronization of interictal eeg discharges in focal epilepsy prevalence and associated factors |
| topic | secondary bilateral synchrony epilepsy interictal EEG epileptiform discharges |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1446471/full |
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