Phosphatidylserine-targeting bis(zinc-dipicolylamine) farnesol inhibits ATP production in cancer cells to overcome multidrug resistance

Phosphatidylserine-targeting bis(zinc-dipicolylamine) farnesol inhibits ATP production in cancer cells to overcome multidrug resistance

Multidrug resistance significantly impedes the efficacy of cancer chemotherapy. Resistance often arises from the reduced cellular uptake of chemotherapeutic drugs, a process crucial for their cytotoxic effects. This reduction is frequently due to transmembrane efflux pumps powered by ATP from mitoch...

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Bibliographic Details
Main Authors: Wei Huang, Xuan Nie, Xiao-Hong Zhou, Lei Qiao, Hong-Jie Gao, Jing Zang, Long-Kang Yu, Long-Hai Wang, Ye-Zi You
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-12-01
Series:Supramolecular Materials
Subjects:
Multidrug resistance
Phosphatidylserine
Zn-dipicolylamine
Online Access:http://www.sciencedirect.com/science/article/pii/S2667240524000060
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