Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19

Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19

Neutrophil dysregulation is well established in COVID-19. However, factors contributing to neutrophil activation in COVID-19 are not clear. We assessed if N-formyl methionine (fMet) contributes to neutrophil activation in COVID-19. Elevated levels of calprotectin, neutrophil extracellular traps (NET...

Full description

Saved in:

Bibliographic Details
Main Authors:	Runa Kuley, Bhargavi Duvvuri, Jeffrey J. Wallin, Nam Bui, Mary Vic Adona, Nicholas G. O’Connor, Sharon K. Sahi, Ian B. Stanaway, Mark M. Wurfel, Eric D. Morrell, W. Conrad Liles, Pavan K. Bhatraju, Christian Lood
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Series:	Virulence
Subjects:	COVID-19 systemic inflammation neutrophils clinical biomarkers N-formyl methionine peptide mitochondrial peptides
Online Access:	https://www.tandfonline.com/doi/10.1080/21505594.2023.2218077
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Formyl-methionine as a degradation signal at the N-termini of bacterial proteins
by: Konstantin I. Piatkov, et al.
Published: (2015-09-01)

Bioactive Compounds as Modulators of N-Formyl Peptide Signaling in Chronic Diseases
by: Livia Alvarenga, et al.
Published: (2025-07-01)

CSF Mitochondrial N-Formyl Methionine Peptide as Complementary Diagnostic Tool in Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis
by: Li C, et al.
Published: (2024-12-01)

Starting with a degron: N-terminal formyl-methionine of nascent bacterial proteins contributes to their proteolytic control
by: R. Jürgen Dohmen
Published: (2015-10-01)

Formyl peptide receptor 2 antagonist WRW4 ameliorates diabetes-induced cognitive decline in mice
by: Hiroki Uno, et al.
Published: (2025-09-01)

Formyl Peptide Receptors 1 and 2: Essential for Immunomodulation of Crotoxin in Human Macrophages, Unrelated to Cellular Entry
by: Luciana de Araújo Pimenta, et al.
Published: (2025-07-01)

The N-formyl peptide receptors: much more than chemoattractant receptors. Relevance in health and disease
by: Filomena Napolitano, et al.
Published: (2025-03-01)

An optimised promoter and signal peptide improves methionine production of a genetically engineered Candida utilis harboring the δ-zein gene
by: Qiburi He, et al.
Published: (2025-07-01)

Methionine metabolism, functions, and application in swine
by: Mengliao Wan, et al.
Published: (2025-09-01)

Temporal dichotomy of neutrophil function in acute liver injury and repair
by: Jennifer A. Cartwright, et al.
Published: (2025-07-01)

Lipoxin A4 analogue, BML-111, reduces platelet activation and protects from thrombosis
by: Shatha AlOmar, et al.
Published: (2024-04-01)

Discovery of Yersinia LcrV as a novel biased agonist of formyl peptide receptor 1 to bi-directionally modulate intracellular kinases in triple-negative breast cancer
by: Yunjun Ge, et al.
Published: (2025-07-01)

FORMYLATION OF 2-(METHYLTHIO)PYRIMDINE-4,6-DIOL IN THE REACTIO CONDITIONS OF VILSMEIER-HAAK (SHORT MESSAGE)
by: E. S. Ofitserova, et al.
Published: (2019-01-01)

Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling
by: Adolf Koudelka, et al.
Published: (2025-01-01)

Growth performance of broiler chickens fed diets containing granulated L-methionine compared with DL-methionine
by: June Hyeok Yoon, et al.
Published: (2025-07-01)

A Chemically Defined TLR3 Agonist with Anticancer Activity
by: Julie Le Naour, et al.
Published: (2023-12-01)

Photocatalytic N-Formylation of CO<sub>2</sub> with Amines Catalyzed by Diethyltriamine Pentaacetic Acid
by: Xuexin Yuan, et al.
Published: (2024-07-01)

Formylation of 2-Methylpyrimidine-4,6-diol Under the Conditions of the Vilsmeier–Haack Reaction
by: Aleksandr V. Dambaev, et al.
Published: (2024-11-01)

Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy
by: VS Pokrovskii, et al.
Published: (2017-07-01)

Comparison of DL-Methionine and L-Methionine levels in liver metabolism activity in commercial broilers fed a diet without antibiotic growth promoters
by: Andriyanto Andriyanto, et al.
Published: (2025-03-01)

Methionine Dependency and Restriction in Cancer: Exploring the Pathogenic Function and Therapeutic Potential
by: Chi Ma, et al.
Published: (2025-04-01)

Effects of Dietary Supplementation of DL-Methionine or DL-Methionine Hydroxyl Analogue (MHA-Ca) on Growth Performance and Blood and Liver Redox Status in Growing Pigs
by: Emmanuel O. Oladejo, et al.
Published: (2024-11-01)

SYNTHESIS AND CRYSTAL STRUCTURE OF A NA(I) COMPLEX WITH 4,4’-BIPYRIDINE AND 2-FORMYL- BENZENESULFONATE-HYDRAZINE
by: TAI XI-SHI, et al.
Published: (2015-07-01)

Methionine as a Spacer between Poly Acrylic acid and Ampicillin
by: Baghdad Science Journal
Published: (2015-09-01)

EFFECT OF METHIONINE AND VITAMIN E SUPPLEMENTATION IN THE RATION ON PRODUCTIVE PERFORMANCE AND SOME PHYSIOLOGICAL CHARACTERS OF BROILER CHICKENS REARED UNDER HIGH TEMPERATURE
by: Duried Younis, et al.
Published: (2018-06-01)

The role of methionine cycle disruption in the initiation and progression of malignant tumors
by: T. G. Ruksha, et al.
Published: (2024-12-01)

HISTOLOGICAL FINDINGS OF THE BURSA OF FABRICIUS IN BROILER CHICKS SUPPLIED WITH THE METHIONINE SUPPLEMENT METHIO GROW
by: Ali Hassan et al.,...
Published: (2020-06-01)

An infant with an extremely rare cobalamin disorder: Methionine synthase deficiency and importance of early diagnosis and treatment
by: Çiğdem Seher Kasapkara, et al.
Published: (2019-04-01)

An investigation of the assumed efficacy of methionine hydroxy analogue compared to DL-methionine by measuring growth performance, carcass traits, and GHR and IGF-I expression in broilers
by: Engin Yenice, et al.
Published: (2023-12-01)

Rumen-protected methionine supplementation improves lactation performance and alleviates inflammation during a subclinical mastitis challenge in lactating dairy cows
by: A. Paz, et al.
Published: (2024-12-01)

Impacts of In Ovo Feeding of DL-Methionine on Hatchability and Chick Weight
by: İsa Coşkun, et al.
Published: (2014-02-01)

Comparison of the effects of taurine and methionine supplementation on the nitrogen metabolism of beef steers elucidated through plasma metabolome profiling
by: Yufeng Liu, et al.
Published: (2025-03-01)

The impact of general anesthesia on methionine metabolism during cardiopulmonary bypass
by: Yu. S. Polushin, et al.
Published: (2020-09-01)

Zinc methionine supplementation during the summer season enhanced the growth, immunity, antioxidants and zinc retention of broiler chickens
by: U S MISHRA, et al.
Published: (2025-06-01)

EFFECT OF FENUGREEK SEEDS (Trigonella foenum graecum), METHIONINE AND INDUCED OXIDATIVE STRESS ON SOME BIOCHEMICAL PARAMETERS AND ANTIOXIDANTS STATUS FOR SOME TISSUES IN QUAIL
by: Saad Al-Nuaimmi, et al.
Published: (2018-03-01)

Methionine Alters the Fecal Microbiota and Enhances the Antioxidant Capacity of Lactating Donkeys
by: Fei Huang, et al.
Published: (2025-02-01)

A study on the function of methionine in growth, immunity, antioxidant, endoplasmic reticulum stress and apoptosis of largemouth bass (Micropterus salmoides)
by: Hualiang Liang, et al.
Published: (2024-12-01)

Protective effects of S-adenosyl methionine on oxidative stress and tissue damage in STZ-induced diabetic rats
by: AmirHossein RahimBakhsh, et al.
Published: (2025-07-01)

Histomorphometric evaluation of the testis after administration of methionine-loaded zinc oxide nano-particles in mice
by: Neda Nazarian, et al.
Published: (2024-05-01)

Targeting Methionine Metabolism Reveals AMPK-SAMTOR Signaling as a Therapeutic Vulnerability in Prostate Cancer
by: Serdar Arisan, et al.
Published: (2025-05-01)