Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease
BACKGROUND/OBJECTIVE: Variants in the interleukin-23 receptor (IL23R) and the autophagy-related 16-like 1 (ATG16L1) genes have been associated with an increased risk of Crohn’s disease (CD). Both genes were identified through genome-wide association scans and subsequent studies have validated these...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2010/480458 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545714751668224 |
|---|---|
| author | Lynn Cotterill Debbie Payne Scott Levison John McLaughlin Emma Wesley Mark Feeney Hilary Durbin Simon Lal Alistair Makin Simon Campbell Stephen A Roberts Catherine O’Neill Cathryn Edwards William G Newman |
| author_facet | Lynn Cotterill Debbie Payne Scott Levison John McLaughlin Emma Wesley Mark Feeney Hilary Durbin Simon Lal Alistair Makin Simon Campbell Stephen A Roberts Catherine O’Neill Cathryn Edwards William G Newman |
| author_sort | Lynn Cotterill |
| collection | DOAJ |
| description | BACKGROUND/OBJECTIVE: Variants in the interleukin-23 receptor (IL23R) and the autophagy-related 16-like 1 (ATG16L1) genes have been associated with an increased risk of Crohn’s disease (CD). Both genes were identified through genome-wide association scans and subsequent studies have validated these associations. To assess the effect size of these variants, an independent case-control association study and meta-analysis were performed. |
| format | Article |
| id | doaj-art-68b1b0ae1634482b969786da1490966c |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-68b1b0ae1634482b969786da1490966c2025-02-03T07:24:52ZengWileyCanadian Journal of Gastroenterology0835-79002010-01-0124529730210.1155/2010/480458Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s DiseaseLynn Cotterill0Debbie Payne1Scott Levison2John McLaughlin3Emma Wesley4Mark Feeney5Hilary Durbin6Simon Lal7Alistair Makin8Simon Campbell9Stephen A Roberts10Catherine O’Neill11Cathryn Edwards12William G Newman13Department of Medical Genetics, Manchester Academic Health; Science Centre, St Mary’s Hospital and University of Manchester, United KingdomCentre for Integrated Genomic Medical Research (CIGMR), University of Manchester, United KingdomDepartment of Gastrointestinal Sciences, University of Manchester, Manchester, United KingdomDepartment of Gastrointestinal Sciences, University of Manchester, Manchester, United KingdomGastroenterology Unit, Torbay Hospital, Torbay, United KingdomGastroenterology Unit, Torbay Hospital, Torbay, United KingdomGastroenterology Unit, Torbay Hospital, Torbay, United KingdomGastroenterology Unit, University Hospital Aintree, Liverpool, United KingdomDepartment of Gastroenterology, Manchester Royal Infirmary, United KingdomDepartment of Gastroenterology, Manchester Royal Infirmary, United KingdomHealth Research Methodology Group, University of Manchester, Manchester, United KingdomDepartment of Gastrointestinal Sciences, University of Manchester, Manchester, United KingdomGastroenterology Unit, Torbay Hospital, Torbay, United KingdomDepartment of Medical Genetics, Manchester Academic Health; Science Centre, St Mary’s Hospital and University of Manchester, United KingdomBACKGROUND/OBJECTIVE: Variants in the interleukin-23 receptor (IL23R) and the autophagy-related 16-like 1 (ATG16L1) genes have been associated with an increased risk of Crohn’s disease (CD). Both genes were identified through genome-wide association scans and subsequent studies have validated these associations. To assess the effect size of these variants, an independent case-control association study and meta-analysis were performed.http://dx.doi.org/10.1155/2010/480458 |
| spellingShingle | Lynn Cotterill Debbie Payne Scott Levison John McLaughlin Emma Wesley Mark Feeney Hilary Durbin Simon Lal Alistair Makin Simon Campbell Stephen A Roberts Catherine O’Neill Cathryn Edwards William G Newman Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease Canadian Journal of Gastroenterology |
| title | Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease |
| title_full | Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease |
| title_fullStr | Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease |
| title_full_unstemmed | Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease |
| title_short | Replication and Meta-Analysis of 13,000 Cases Defines the Risk for Interleukin-23 Receptor and Autophagy-Related 16-Like 1 Variants in Crohn’s Disease |
| title_sort | replication and meta analysis of 13 000 cases defines the risk for interleukin 23 receptor and autophagy related 16 like 1 variants in crohn s disease |
| url | http://dx.doi.org/10.1155/2010/480458 |
| work_keys_str_mv | AT lynncotterill replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT debbiepayne replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT scottlevison replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT johnmclaughlin replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT emmawesley replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT markfeeney replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT hilarydurbin replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT simonlal replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT alistairmakin replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT simoncampbell replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT stephenaroberts replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT catherineoneill replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT cathrynedwards replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease AT williamgnewman replicationandmetaanalysisof13000casesdefinestheriskforinterleukin23receptorandautophagyrelated16like1variantsincrohnsdisease |