Post-TB sequelae in adolescent pulmonary TB survivors
OBJECTIVE: To compare the persistent clinical symptoms, chest X-ray (CXR), spirometry and echocardiography results in adolescent survivors of drug-susceptible (DS) and drug-resistant (DR) pulmonary TB (PTB). METHODS: This retrospective cohort study was conducted in 52 adolescent PTB survivors. We co...
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International Union Against Tuberculosis and Lung Disease (The Union)
2025-01-01
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| Series: | IJTLD Open |
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| Online Access: | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000001/art00005 |
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| author | C. Cesilia F.R. Rinawan P. Santoso H.M. Nataprawira |
| author_facet | C. Cesilia F.R. Rinawan P. Santoso H.M. Nataprawira |
| author_sort | C. Cesilia |
| collection | DOAJ |
| description | OBJECTIVE: To compare the persistent clinical symptoms, chest X-ray (CXR), spirometry and echocardiography results in adolescent survivors of drug-susceptible (DS) and drug-resistant (DR) pulmonary TB (PTB). METHODS: This retrospective cohort study was conducted in 52 adolescent PTB survivors. We compared persistent clinical symptoms, CXR, spirometry and echocardiography in DS-TB and DR-TB survivors. χ 2 test was used to compare groups (P < 0.05 significant), logistic regression analysis was used to identify risk factors, and Many-Factor Rasch Measurement Version Facets 3.86.0 was used to assess the multi-rater agreement of CXR. RESULTS: Significant differences were found in persistent clinical symptoms (higher in DS-TB survivors), CXR, and spirometry abnormalities (higher in DR-TB survivors). The echocardiography revealed a low pulmonary hypertension probability in both groups. Adolescent PTB survivors with comorbidity have 1.5 times the risk of developing pulmonary sequelae compared to non-sequelae. CONCLUSION: Pulmonary sequelae in adolescent PTB survivors were documented in both DS and DR-TB. Monitoring after treatment completion was necessary for PTB survivors, especially in adolescents. |
| format | Article |
| id | doaj-art-6882e978d06a4137bf484c07d6709d6e |
| institution | Kabale University |
| issn | 3005-7590 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-6882e978d06a4137bf484c07d6709d6e2025-01-23T13:39:30ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902025-01-0121192510.5588/ijtldopen.24.00395Post-TB sequelae in adolescent pulmonary TB survivorsC. Cesilia0F.R. Rinawan1P. Santoso2H.M. Nataprawira3Division of Respirology, Department of Child Health, Faculty of Medicine, Universitas Padjadjaran/Dr Hasan Sadikin General Hospital, Bandung, Indonesia;Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia;Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Dr Hasan Sadikin General Hospital, Bandung, Indonesia.Division of Respirology, Department of Child Health, Faculty of Medicine, Universitas Padjadjaran/Dr Hasan Sadikin General Hospital, Bandung, Indonesia;OBJECTIVE: To compare the persistent clinical symptoms, chest X-ray (CXR), spirometry and echocardiography results in adolescent survivors of drug-susceptible (DS) and drug-resistant (DR) pulmonary TB (PTB). METHODS: This retrospective cohort study was conducted in 52 adolescent PTB survivors. We compared persistent clinical symptoms, CXR, spirometry and echocardiography in DS-TB and DR-TB survivors. χ 2 test was used to compare groups (P < 0.05 significant), logistic regression analysis was used to identify risk factors, and Many-Factor Rasch Measurement Version Facets 3.86.0 was used to assess the multi-rater agreement of CXR. RESULTS: Significant differences were found in persistent clinical symptoms (higher in DS-TB survivors), CXR, and spirometry abnormalities (higher in DR-TB survivors). The echocardiography revealed a low pulmonary hypertension probability in both groups. Adolescent PTB survivors with comorbidity have 1.5 times the risk of developing pulmonary sequelae compared to non-sequelae. CONCLUSION: Pulmonary sequelae in adolescent PTB survivors were documented in both DS and DR-TB. Monitoring after treatment completion was necessary for PTB survivors, especially in adolescents.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000001/art00005adolescentchildrenpost-tuberculosis lung diseasetuberculosis |
| spellingShingle | C. Cesilia F.R. Rinawan P. Santoso H.M. Nataprawira Post-TB sequelae in adolescent pulmonary TB survivors IJTLD Open adolescent children post-tuberculosis lung disease tuberculosis |
| title | Post-TB sequelae in adolescent pulmonary TB survivors |
| title_full | Post-TB sequelae in adolescent pulmonary TB survivors |
| title_fullStr | Post-TB sequelae in adolescent pulmonary TB survivors |
| title_full_unstemmed | Post-TB sequelae in adolescent pulmonary TB survivors |
| title_short | Post-TB sequelae in adolescent pulmonary TB survivors |
| title_sort | post tb sequelae in adolescent pulmonary tb survivors |
| topic | adolescent children post-tuberculosis lung disease tuberculosis |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2025/00000002/00000001/art00005 |
| work_keys_str_mv | AT ccesilia posttbsequelaeinadolescentpulmonarytbsurvivors AT frrinawan posttbsequelaeinadolescentpulmonarytbsurvivors AT psantoso posttbsequelaeinadolescentpulmonarytbsurvivors AT hmnataprawira posttbsequelaeinadolescentpulmonarytbsurvivors |