Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling

Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling

The activation of IP3 receptor (IP3R) Ca2+ channels generates agonist-mediated Ca2+ signals that are critical for the regulation of a wide range of biological processes. It is therefore surprising that CRISPR induced loss of all three IP3R isoforms (TKO) in HEK293 and HeLa cell lines yields cells th...

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Bibliographic Details
Main Authors: Michael Young, David M. Booth, David Smith, Marco Tigano, Gyӧrgy Hajnόczky, Suresh K. Joseph
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
calcium signaling
IP3 receptor
Ca2+ dependent transcription
NFAT
CREB
calcineurin
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1473210/full
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