Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke
Motor capability recovery after ischemic stroke involves dynamic remodeling processes of neural connectomes in the nervous system. Various neuromodulatory strategies combining direct stimulating interventions with behavioral trainings for motor recovery after ischemic stroke have been developed. How...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2019/5271573 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562049772683264 |
|---|---|
| author | Changbo Lu Xianglong Wu Hongzhe Ma Qingchuan Wang Yikai Wang Yan Luo Cong Li Hui Xu |
| author_facet | Changbo Lu Xianglong Wu Hongzhe Ma Qingchuan Wang Yikai Wang Yan Luo Cong Li Hui Xu |
| author_sort | Changbo Lu |
| collection | DOAJ |
| description | Motor capability recovery after ischemic stroke involves dynamic remodeling processes of neural connectomes in the nervous system. Various neuromodulatory strategies combining direct stimulating interventions with behavioral trainings for motor recovery after ischemic stroke have been developed. However, the effectiveness of these interventions varies widely due to unspecific activation or inhibition of undefined neuronal subtypes. Optogenetics is a functional and structural connection-based approach that can selectively activate or inhibit specific subtype neurons with a higher precision, and it has been widely applied to build up neuronal plasticities of the nervous system, which shows a great potential in restoring motor functions in stroke animal models. Here, we reviewed neurobiological mechanisms of enhanced brain plasticities underlying motor recovery through the optogenetic stimulation after ischemic stroke. Several brain sites and neural circuits that have been previously proven effective for motor function rehabilitation were identified, which would be helpful for a more schematic understanding of effective neuronal connectomes in the motor function recovery after ischemic stroke. |
| format | Article |
| id | doaj-art-68762f94c7514abbbe5c0758f50878f6 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-68762f94c7514abbbe5c0758f50878f62025-02-03T01:23:34ZengWileyNeural Plasticity2090-59041687-54432019-01-01201910.1155/2019/52715735271573Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic StrokeChangbo Lu0Xianglong Wu1Hongzhe Ma2Qingchuan Wang3Yikai Wang4Yan Luo5Cong Li6Hui Xu7Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaKey Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaDepartment of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, ChinaMotor capability recovery after ischemic stroke involves dynamic remodeling processes of neural connectomes in the nervous system. Various neuromodulatory strategies combining direct stimulating interventions with behavioral trainings for motor recovery after ischemic stroke have been developed. However, the effectiveness of these interventions varies widely due to unspecific activation or inhibition of undefined neuronal subtypes. Optogenetics is a functional and structural connection-based approach that can selectively activate or inhibit specific subtype neurons with a higher precision, and it has been widely applied to build up neuronal plasticities of the nervous system, which shows a great potential in restoring motor functions in stroke animal models. Here, we reviewed neurobiological mechanisms of enhanced brain plasticities underlying motor recovery through the optogenetic stimulation after ischemic stroke. Several brain sites and neural circuits that have been previously proven effective for motor function rehabilitation were identified, which would be helpful for a more schematic understanding of effective neuronal connectomes in the motor function recovery after ischemic stroke.http://dx.doi.org/10.1155/2019/5271573 |
| spellingShingle | Changbo Lu Xianglong Wu Hongzhe Ma Qingchuan Wang Yikai Wang Yan Luo Cong Li Hui Xu Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke Neural Plasticity |
| title | Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke |
| title_full | Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke |
| title_fullStr | Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke |
| title_full_unstemmed | Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke |
| title_short | Optogenetic Stimulation Enhanced Neuronal Plasticities in Motor Recovery after Ischemic Stroke |
| title_sort | optogenetic stimulation enhanced neuronal plasticities in motor recovery after ischemic stroke |
| url | http://dx.doi.org/10.1155/2019/5271573 |
| work_keys_str_mv | AT changbolu optogeneticstimulationenhancedneuronalplasticitiesinmotorrecoveryafterischemicstroke AT xianglongwu optogeneticstimulationenhancedneuronalplasticitiesinmotorrecoveryafterischemicstroke AT hongzhema optogeneticstimulationenhancedneuronalplasticitiesinmotorrecoveryafterischemicstroke AT qingchuanwang optogeneticstimulationenhancedneuronalplasticitiesinmotorrecoveryafterischemicstroke AT yikaiwang optogeneticstimulationenhancedneuronalplasticitiesinmotorrecoveryafterischemicstroke AT yanluo optogeneticstimulationenhancedneuronalplasticitiesinmotorrecoveryafterischemicstroke AT congli optogeneticstimulationenhancedneuronalplasticitiesinmotorrecoveryafterischemicstroke AT huixu optogeneticstimulationenhancedneuronalplasticitiesinmotorrecoveryafterischemicstroke |