The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from Healthy Subjects
This study aimed at determining the concentration of P-selectins in lung cancer patients in different stages and healthy subjects. Then, the ability of the methodology developed to discriminate the existence of lung cancer was also evaluated. Serum spectra were obtained using Raman spectroscopy (RS)...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2018/7843208 |
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| author | Edyta Wolny-Rokicka Andrzej Tukiendorf Jerzy Wydmański Agnieszka Zembroń-Łacny |
| author_facet | Edyta Wolny-Rokicka Andrzej Tukiendorf Jerzy Wydmański Agnieszka Zembroń-Łacny |
| author_sort | Edyta Wolny-Rokicka |
| collection | DOAJ |
| description | This study aimed at determining the concentration of P-selectins in lung cancer patients in different stages and healthy subjects. Then, the ability of the methodology developed to discriminate the existence of lung cancer was also evaluated. Serum spectra were obtained using Raman spectroscopy (RS). Blood samples were taken from subjects divided into two groups: group 1—comparing data from 22 patients clinically diagnosed with cancer before versus after medical intervention; group 2—comparing data from 10 palliative patients versus 17 healthy volunteers. The RS analysis of the samples revealed the presence of five very similar peaks in both groups 1 and 2. This leads to the conclusion that a medical intervention in cancer cases gives results comparable to those obtained from healthy subjects. The study indicates that the use of Raman spectroscopy can produce a better classification of cancer patients. However, diagnostically the results have not been statistically significant, probably due to the limited number of samples gathered. A larger number of samples would be required for future verification. |
| format | Article |
| id | doaj-art-686cba6d10d3446082c355553fc13c0e |
| institution | Kabale University |
| issn | 2314-4920 2314-4939 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-686cba6d10d3446082c355553fc13c0e2025-02-03T01:24:19ZengWileyJournal of Spectroscopy2314-49202314-49392018-01-01201810.1155/2018/78432087843208The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from Healthy SubjectsEdyta Wolny-Rokicka0Andrzej Tukiendorf1Jerzy Wydmański2Agnieszka Zembroń-Łacny3Department of Radiotherapy, Provincial Multidisciplinary Hospital in Gorzów Wielkopolski, ul Dekerta 1, 66-400 Gorzów Wielkopolski, PolandSocial Medicine Department, Medical University in Wrocław, ul. Bujwida 44, 50-345 Wrocław, PolandDepartment of Radiotherapy, Center of Oncology-Maria Skłodowska-Curie Memorial Institute, Branch in Gliwice, ul. Wybrzeża Armii Krajowej 15, 44-101 Gliwice, PolandFaculty of Medicine and Health Sciences, University of Zielona Góra, ul. Zyty 28, 65-046 Zielona Góra, PolandThis study aimed at determining the concentration of P-selectins in lung cancer patients in different stages and healthy subjects. Then, the ability of the methodology developed to discriminate the existence of lung cancer was also evaluated. Serum spectra were obtained using Raman spectroscopy (RS). Blood samples were taken from subjects divided into two groups: group 1—comparing data from 22 patients clinically diagnosed with cancer before versus after medical intervention; group 2—comparing data from 10 palliative patients versus 17 healthy volunteers. The RS analysis of the samples revealed the presence of five very similar peaks in both groups 1 and 2. This leads to the conclusion that a medical intervention in cancer cases gives results comparable to those obtained from healthy subjects. The study indicates that the use of Raman spectroscopy can produce a better classification of cancer patients. However, diagnostically the results have not been statistically significant, probably due to the limited number of samples gathered. A larger number of samples would be required for future verification.http://dx.doi.org/10.1155/2018/7843208 |
| spellingShingle | Edyta Wolny-Rokicka Andrzej Tukiendorf Jerzy Wydmański Agnieszka Zembroń-Łacny The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from Healthy Subjects Journal of Spectroscopy |
| title | The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from Healthy Subjects |
| title_full | The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from Healthy Subjects |
| title_fullStr | The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from Healthy Subjects |
| title_full_unstemmed | The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from Healthy Subjects |
| title_short | The Potential of the Quick Detection of Selectins Using Raman Spectroscopy to Discriminate Lung Cancer Patients from Healthy Subjects |
| title_sort | potential of the quick detection of selectins using raman spectroscopy to discriminate lung cancer patients from healthy subjects |
| url | http://dx.doi.org/10.1155/2018/7843208 |
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