The prevalence and characteristics of cow's milk protein allergy in infants and young children with iron deficiency anemia
Background: The clinical presentation of cow's milk protein allergy (CMPA) in children varies. This retrospective study aimed to investigate the prevalence and clinical manifestations of CMPA in young children who visited for evaluation of iron deficiency anemia (IDA). Methods: Patients aged &l...
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Elsevier
2018-02-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957217303868 |
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| author | Fu-Ping Lai Yao-Jong Yang |
| author_facet | Fu-Ping Lai Yao-Jong Yang |
| author_sort | Fu-Ping Lai |
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| description | Background: The clinical presentation of cow's milk protein allergy (CMPA) in children varies. This retrospective study aimed to investigate the prevalence and clinical manifestations of CMPA in young children who visited for evaluation of iron deficiency anemia (IDA). Methods: Patients aged <4 years who were diagnosed as having IDA (serum ferritin <12 ng/mL) at the National Cheng Kung University Hospital, Taiwan in the period 2005–2015 were reviewed. Their clinical presentations, laboratory data, endoscopy findings, and prognosis were analyzed. Results: Seven of 51 IDA patients (13.7%) had CMPA. The pallor (100%), failure to thrive (43%), and general edema (43%) were the common features. Six (86%) had hypoalbuminemia and four (57%) had positive occult blood in the stool. Of the five patients who underwent skin prick test, four (80%) had positive results. Most of the colonoscopies revealed erosive and hemorrhagic colitis and lymphoid hyperplasia, but none of the biopsies demonstrated eosinophilia in the lamina propria. All of the patients recovered from their IDA within seven months of cow's milk protein elimination and iron supplementation. Conclusion: CMPA should be considered in young children with undetermined IDA. Cow's milk protein elimination and iron supplementation help in the recovery. |
| format | Article |
| id | doaj-art-6860dd4b53204de0aacf81333aafaa2a |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2018-02-01 |
| publisher | Elsevier |
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| series | Pediatrics and Neonatology |
| spelling | doaj-art-6860dd4b53204de0aacf81333aafaa2a2025-08-20T02:00:39ZengElsevierPediatrics and Neonatology1875-95722018-02-01591485210.1016/j.pedneo.2017.01.004The prevalence and characteristics of cow's milk protein allergy in infants and young children with iron deficiency anemiaFu-Ping Lai0Yao-Jong Yang1Departments of Pediatrics, National Cheng Kung University Hospital, Medical College, National Cheng Kung University, TaiwanCorresponding author. Department of Pediatrics, National Cheng Kung University and Hospital, 138 Sheng Li Rd, Tainan 704, Taiwan. Fax: +886 6 275 3083.; Departments of Pediatrics, National Cheng Kung University Hospital, Medical College, National Cheng Kung University, TaiwanBackground: The clinical presentation of cow's milk protein allergy (CMPA) in children varies. This retrospective study aimed to investigate the prevalence and clinical manifestations of CMPA in young children who visited for evaluation of iron deficiency anemia (IDA). Methods: Patients aged <4 years who were diagnosed as having IDA (serum ferritin <12 ng/mL) at the National Cheng Kung University Hospital, Taiwan in the period 2005–2015 were reviewed. Their clinical presentations, laboratory data, endoscopy findings, and prognosis were analyzed. Results: Seven of 51 IDA patients (13.7%) had CMPA. The pallor (100%), failure to thrive (43%), and general edema (43%) were the common features. Six (86%) had hypoalbuminemia and four (57%) had positive occult blood in the stool. Of the five patients who underwent skin prick test, four (80%) had positive results. Most of the colonoscopies revealed erosive and hemorrhagic colitis and lymphoid hyperplasia, but none of the biopsies demonstrated eosinophilia in the lamina propria. All of the patients recovered from their IDA within seven months of cow's milk protein elimination and iron supplementation. Conclusion: CMPA should be considered in young children with undetermined IDA. Cow's milk protein elimination and iron supplementation help in the recovery.http://www.sciencedirect.com/science/article/pii/S1875957217303868cow's milk protein allergyiron deficiency anemiahypoalbuminemiaendoscopy |
| spellingShingle | Fu-Ping Lai Yao-Jong Yang The prevalence and characteristics of cow's milk protein allergy in infants and young children with iron deficiency anemia Pediatrics and Neonatology cow's milk protein allergy iron deficiency anemia hypoalbuminemia endoscopy |
| title | The prevalence and characteristics of cow's milk protein allergy in infants and young children with iron deficiency anemia |
| title_full | The prevalence and characteristics of cow's milk protein allergy in infants and young children with iron deficiency anemia |
| title_fullStr | The prevalence and characteristics of cow's milk protein allergy in infants and young children with iron deficiency anemia |
| title_full_unstemmed | The prevalence and characteristics of cow's milk protein allergy in infants and young children with iron deficiency anemia |
| title_short | The prevalence and characteristics of cow's milk protein allergy in infants and young children with iron deficiency anemia |
| title_sort | prevalence and characteristics of cow s milk protein allergy in infants and young children with iron deficiency anemia |
| topic | cow's milk protein allergy iron deficiency anemia hypoalbuminemia endoscopy |
| url | http://www.sciencedirect.com/science/article/pii/S1875957217303868 |
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