The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment
The type 2 diabetes pandemic in recent decades is a huge global health threat. This pandemic is primarily attributed to the surplus of nutrients and the increased prevalence of obesity worldwide. In contrast, calorie restriction and weight reduction can drastically prevent type 2 diabetes, indicatin...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/972891 |
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| author | Yi-Cheng Chang Siow-Wey Hee Meng-Lun Hsieh Yung-Ming Jeng Lee-Ming Chuang |
| author_facet | Yi-Cheng Chang Siow-Wey Hee Meng-Lun Hsieh Yung-Ming Jeng Lee-Ming Chuang |
| author_sort | Yi-Cheng Chang |
| collection | DOAJ |
| description | The type 2 diabetes pandemic in recent decades is a huge global health threat. This pandemic is primarily attributed to the surplus of nutrients and the increased prevalence of obesity worldwide. In contrast, calorie restriction and weight reduction can drastically prevent type 2 diabetes, indicating a central role of nutrient excess in the development of diabetes. Recently, the molecular links between excessive nutrients, organelle stress, and development of metabolic disease have been extensively studied. Specifically, excessive nutrients trigger endoplasmic reticulum stress and increase the production of mitochondrial reactive oxygen species, leading to activation of stress signaling pathway, inflammatory response, lipogenesis, and pancreatic beta-cell death. Autophagy is required for clearance of hepatic lipid clearance, alleviation of pancreatic beta-cell stress, and white adipocyte differentiation. ROS scavengers, chemical chaperones, and autophagy activators have demonstrated promising effects for the treatment of insulin resistance and diabetes in preclinical models. Further results from clinical trials are eagerly awaited. |
| format | Article |
| id | doaj-art-6855be96f28f481487ef40b78605457f |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-6855be96f28f481487ef40b78605457f2025-02-03T05:45:46ZengWileyAnalytical Cellular Pathology2210-71772210-71852015-01-01201510.1155/2015/972891972891The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for TreatmentYi-Cheng Chang0Siow-Wey Hee1Meng-Lun Hsieh2Yung-Ming Jeng3Lee-Ming Chuang4Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei 100, TaiwanDepartment of Internal Medicine and Center for Obesity, Lifestyle and Metabolic Surgery, National Taiwan University Hospital, Taipei 100, TaiwanGraduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei 100, TaiwanGraduate Institute of Pathology, National Taiwan University, Taipei 100, TaiwanDepartment of Internal Medicine and Center for Obesity, Lifestyle and Metabolic Surgery, National Taiwan University Hospital, Taipei 100, TaiwanThe type 2 diabetes pandemic in recent decades is a huge global health threat. This pandemic is primarily attributed to the surplus of nutrients and the increased prevalence of obesity worldwide. In contrast, calorie restriction and weight reduction can drastically prevent type 2 diabetes, indicating a central role of nutrient excess in the development of diabetes. Recently, the molecular links between excessive nutrients, organelle stress, and development of metabolic disease have been extensively studied. Specifically, excessive nutrients trigger endoplasmic reticulum stress and increase the production of mitochondrial reactive oxygen species, leading to activation of stress signaling pathway, inflammatory response, lipogenesis, and pancreatic beta-cell death. Autophagy is required for clearance of hepatic lipid clearance, alleviation of pancreatic beta-cell stress, and white adipocyte differentiation. ROS scavengers, chemical chaperones, and autophagy activators have demonstrated promising effects for the treatment of insulin resistance and diabetes in preclinical models. Further results from clinical trials are eagerly awaited.http://dx.doi.org/10.1155/2015/972891 |
| spellingShingle | Yi-Cheng Chang Siow-Wey Hee Meng-Lun Hsieh Yung-Ming Jeng Lee-Ming Chuang The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment Analytical Cellular Pathology |
| title | The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment |
| title_full | The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment |
| title_fullStr | The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment |
| title_full_unstemmed | The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment |
| title_short | The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment |
| title_sort | role of organelle stresses in diabetes mellitus and obesity implication for treatment |
| url | http://dx.doi.org/10.1155/2015/972891 |
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