First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population
Background. Uric acid is a powerful free-radical scavenger in humans, but hyperuricemia may induce insulin resistance and beta-cell dysfunction. The study aimed to evaluate the association between hyperuricemia and hyperglycemia, considering the confounding factors in a Vietnamese population. Method...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/5275071 |
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| author | Tran Quang Binh Pham Tran Phuong Nguyen Thanh Chung Bui Thi Nhung Do Dinh Tung Tran Quang Thuyen Duong Tuan Linh Bui Thi Thuy Nga Nguyen Anh Ngoc Le Danh Tuyen |
| author_facet | Tran Quang Binh Pham Tran Phuong Nguyen Thanh Chung Bui Thi Nhung Do Dinh Tung Tran Quang Thuyen Duong Tuan Linh Bui Thi Thuy Nga Nguyen Anh Ngoc Le Danh Tuyen |
| author_sort | Tran Quang Binh |
| collection | DOAJ |
| description | Background. Uric acid is a powerful free-radical scavenger in humans, but hyperuricemia may induce insulin resistance and beta-cell dysfunction. The study aimed to evaluate the association between hyperuricemia and hyperglycemia, considering the confounding factors in a Vietnamese population. Methods. A population-based cross-sectional study recruited 1542 adults aged 50 to 70 years to collect data on socioeconomic status, lifestyle factors, and clinical patterns. Associations between hyperuricemia and hyperglycemia (isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), combined IFG-IGT, and type 2 diabetes (T2D)) were evaluated by multinomial logistic regression analysis in several models, adjusting for the confounding factors including socioeconomic status, lifestyle factors, and clinical measures. Results. Uric acid values were much higher in IFG, IFG-IGT, and T2D groups compared to those in the normal glucose tolerance (NGT) group. The significant association of hyperuricemia with IFG, IFG-IGT, and T2D was found in the model unadjusted and remained consistently in several models adjusted for socioeconomic status, lifestyle factors, and clinical patterns. In the final model, the consistent hyperglycemia risk was found in total sample (OR = 2.23 for IFG, OR = 2.29 for IFG-IGT, and 1.75 for T2D, P≤0.006) and in women (OR = 2.90 for IFG, OR = 3.96 for IFG-IGT, and OR = 2.49 for T2D, P<0.001) but not in men. Conclusions. It is the first report in Vietnamese population suggesting the significant association of hyperuricemia with IFG, IFG-IGT, and T2D; and the predominant association was found in women than in men, taken into account the confounding factors. |
| format | Article |
| id | doaj-art-685408a4ba15476f83f4fbdbb7f4d439 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-685408a4ba15476f83f4fbdbb7f4d4392025-02-03T00:59:15ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/52750715275071First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese PopulationTran Quang Binh0Pham Tran Phuong1Nguyen Thanh Chung2Bui Thi Nhung3Do Dinh Tung4Tran Quang Thuyen5Duong Tuan Linh6Bui Thi Thuy Nga7Nguyen Anh Ngoc8Le Danh Tuyen9National Institute of Nutrition, 48B Tang Bat Ho Street, Hanoi, VietnamNational Institute of Nutrition, 48B Tang Bat Ho Street, Hanoi, VietnamNational Institute of Hygiene and Epidemiology, 1 Yersin, Hanoi, VietnamNational Institute of Nutrition, 48B Tang Bat Ho Street, Hanoi, VietnamNational Institute of Diabetes and Metabolic Disorders, 1 Ton That Tung, Hanoi, VietnamVietnam Military Medical University, 160 Phung Hung Street, Ha Dong, Hanoi, VietnamNational Institute of Nutrition, 48B Tang Bat Ho Street, Hanoi, VietnamNational Institute of Nutrition, 48B Tang Bat Ho Street, Hanoi, VietnamNational Institute of Nutrition, 48B Tang Bat Ho Street, Hanoi, VietnamNational Institute of Nutrition, 48B Tang Bat Ho Street, Hanoi, VietnamBackground. Uric acid is a powerful free-radical scavenger in humans, but hyperuricemia may induce insulin resistance and beta-cell dysfunction. The study aimed to evaluate the association between hyperuricemia and hyperglycemia, considering the confounding factors in a Vietnamese population. Methods. A population-based cross-sectional study recruited 1542 adults aged 50 to 70 years to collect data on socioeconomic status, lifestyle factors, and clinical patterns. Associations between hyperuricemia and hyperglycemia (isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), combined IFG-IGT, and type 2 diabetes (T2D)) were evaluated by multinomial logistic regression analysis in several models, adjusting for the confounding factors including socioeconomic status, lifestyle factors, and clinical measures. Results. Uric acid values were much higher in IFG, IFG-IGT, and T2D groups compared to those in the normal glucose tolerance (NGT) group. The significant association of hyperuricemia with IFG, IFG-IGT, and T2D was found in the model unadjusted and remained consistently in several models adjusted for socioeconomic status, lifestyle factors, and clinical patterns. In the final model, the consistent hyperglycemia risk was found in total sample (OR = 2.23 for IFG, OR = 2.29 for IFG-IGT, and 1.75 for T2D, P≤0.006) and in women (OR = 2.90 for IFG, OR = 3.96 for IFG-IGT, and OR = 2.49 for T2D, P<0.001) but not in men. Conclusions. It is the first report in Vietnamese population suggesting the significant association of hyperuricemia with IFG, IFG-IGT, and T2D; and the predominant association was found in women than in men, taken into account the confounding factors.http://dx.doi.org/10.1155/2019/5275071 |
| spellingShingle | Tran Quang Binh Pham Tran Phuong Nguyen Thanh Chung Bui Thi Nhung Do Dinh Tung Tran Quang Thuyen Duong Tuan Linh Bui Thi Thuy Nga Nguyen Anh Ngoc Le Danh Tuyen First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population International Journal of Endocrinology |
| title | First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population |
| title_full | First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population |
| title_fullStr | First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population |
| title_full_unstemmed | First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population |
| title_short | First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population |
| title_sort | first report on association of hyperuricemia with type 2 diabetes in a vietnamese population |
| url | http://dx.doi.org/10.1155/2019/5275071 |
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