Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension
With rising altitude the partial pressure of oxygen falls. This phenomenon leads to hypobaric hypoxia at high altitude. Since more than 140 million people permanently live at heights above 2500 m and more than 35 million travel to these heights each year, understanding the mechanisms resulting in ac...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2017/8381653 |
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| _version_ | 1832553945978896384 |
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| author | Jan Grimminger Manuel Richter Khodr Tello Natascha Sommer Henning Gall Hossein Ardeschir Ghofrani |
| author_facet | Jan Grimminger Manuel Richter Khodr Tello Natascha Sommer Henning Gall Hossein Ardeschir Ghofrani |
| author_sort | Jan Grimminger |
| collection | DOAJ |
| description | With rising altitude the partial pressure of oxygen falls. This phenomenon leads to hypobaric hypoxia at high altitude. Since more than 140 million people permanently live at heights above 2500 m and more than 35 million travel to these heights each year, understanding the mechanisms resulting in acute or chronic maladaptation of the human body to these circumstances is crucial. This review summarizes current knowledge of the body’s acute response to these circumstances, possible complications and their treatment, and health care issues resulting from long-term exposure to high altitude. It furthermore describes the characteristic mechanisms of adaptation to life in hypobaric hypoxia expressed by the three major ethnic groups permanently dwelling at high altitude. We additionally summarize current knowledge regarding possible treatment options for hypoxia-induced pulmonary hypertension by reviewing in vitro, rodent, and human studies in this area of research. |
| format | Article |
| id | doaj-art-684d2a3dca6a4dcdb0d08c5c01a0ee69 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-684d2a3dca6a4dcdb0d08c5c01a0ee692025-02-03T05:52:48ZengWileyCanadian Respiratory Journal1198-22411916-72452017-01-01201710.1155/2017/83816538381653Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary HypertensionJan Grimminger0Manuel Richter1Khodr Tello2Natascha Sommer3Henning Gall4Hossein Ardeschir Ghofrani5Department of Internal Medicine, University Clinic Hamburg Eppendorf, University of Hamburg, Martinistrasse 52, 20246 Hamburg, GermanyDepartment of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Klinikstrasse 33, 35392 Giessen, GermanyDepartment of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Klinikstrasse 33, 35392 Giessen, GermanyWith rising altitude the partial pressure of oxygen falls. This phenomenon leads to hypobaric hypoxia at high altitude. Since more than 140 million people permanently live at heights above 2500 m and more than 35 million travel to these heights each year, understanding the mechanisms resulting in acute or chronic maladaptation of the human body to these circumstances is crucial. This review summarizes current knowledge of the body’s acute response to these circumstances, possible complications and their treatment, and health care issues resulting from long-term exposure to high altitude. It furthermore describes the characteristic mechanisms of adaptation to life in hypobaric hypoxia expressed by the three major ethnic groups permanently dwelling at high altitude. We additionally summarize current knowledge regarding possible treatment options for hypoxia-induced pulmonary hypertension by reviewing in vitro, rodent, and human studies in this area of research.http://dx.doi.org/10.1155/2017/8381653 |
| spellingShingle | Jan Grimminger Manuel Richter Khodr Tello Natascha Sommer Henning Gall Hossein Ardeschir Ghofrani Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension Canadian Respiratory Journal |
| title | Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension |
| title_full | Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension |
| title_fullStr | Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension |
| title_full_unstemmed | Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension |
| title_short | Thin Air Resulting in High Pressure: Mountain Sickness and Hypoxia-Induced Pulmonary Hypertension |
| title_sort | thin air resulting in high pressure mountain sickness and hypoxia induced pulmonary hypertension |
| url | http://dx.doi.org/10.1155/2017/8381653 |
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