Effect of Nebulized Morphine on Dyspnea of Mustard Gas-Exposed Patients: A Double-Blind Randomized Clinical Trial Study
Background. Dyspnea is one of the main complaints in a group of COPD patients due to exposure to sulfur mustard (SM) and is refractory to conventional therapies. We designed this study to evaluate effectiveness of nebulized morphine in such patients. Materials and Methods. In a double-blind clinical...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/610921 |
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| author | Majid Shohrati Mostafa Ghanei Asghar Amini Harandi Soniya Foroghi Ali Amini Harandi |
| author_facet | Majid Shohrati Mostafa Ghanei Asghar Amini Harandi Soniya Foroghi Ali Amini Harandi |
| author_sort | Majid Shohrati |
| collection | DOAJ |
| description | Background. Dyspnea is one of the main complaints in a group of COPD patients due to exposure to sulfur mustard (SM) and is refractory to conventional therapies. We designed this study to evaluate effectiveness of nebulized morphine in such patients. Materials and Methods. In a double-blind clinical trial study, 40 patients with documented history of exposure to SM were allocated to two groups: group 1 who received 1 mg morphine sulfate diluted by 4 cc normal saline 0.5% using nebulizer once daily for 5 days and group 2 serving as control who received normal saline as placebo. They were visited by pulmonologist 7 times per day to check symptoms and signs and adverse events. Different parameters including patient-scored peak expiratory flow using pick flow meter, visual analogue scale (VAS) for dyspnea, global quality of life and cough, and number of respiratory rate, night time awaking for dyspnea and cough have been assessed. Results. The scores of VAS for dyspnea, cough and quality of life and also respiratory rate, heart rate, and night time awaking due to dyspnea and night time awaking due to cough improved significantly after morphine nebulization without any major adverse events. Also pick expiratory flow has been improved significantly after nebulization in each day. Conclusion. Our results showed the clinical benefit of nebulized morphine on respiratory complaints of patients due to exposure to SM without significant side effects. |
| format | Article |
| id | doaj-art-6846ce86402d4c80ab7b960d4b4344ad |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-6846ce86402d4c80ab7b960d4b4344ad2025-02-03T05:53:48ZengWileyPulmonary Medicine2090-18362090-18442012-01-01201210.1155/2012/610921610921Effect of Nebulized Morphine on Dyspnea of Mustard Gas-Exposed Patients: A Double-Blind Randomized Clinical Trial StudyMajid Shohrati0Mostafa Ghanei1Asghar Amini Harandi2Soniya Foroghi3Ali Amini Harandi4Research Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Mollasadra Street, P.O. Box 19945-546, Tehran, IranResearch Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Mollasadra Street, P.O. Box 19945-546, Tehran, IranSchool of Medicine, Jahrom University of Medical Sciences, Jahrom 7414846199, IranResearch Center of Chemical Injuries, Baqiyatallah Medical Sciences University, Mollasadra Street, P.O. Box 19945-546, Tehran, IranDepartment of Neurology, Shahid Beheshti University of Medical Sciences and Health Services, Tehran 19839-63113, IranBackground. Dyspnea is one of the main complaints in a group of COPD patients due to exposure to sulfur mustard (SM) and is refractory to conventional therapies. We designed this study to evaluate effectiveness of nebulized morphine in such patients. Materials and Methods. In a double-blind clinical trial study, 40 patients with documented history of exposure to SM were allocated to two groups: group 1 who received 1 mg morphine sulfate diluted by 4 cc normal saline 0.5% using nebulizer once daily for 5 days and group 2 serving as control who received normal saline as placebo. They were visited by pulmonologist 7 times per day to check symptoms and signs and adverse events. Different parameters including patient-scored peak expiratory flow using pick flow meter, visual analogue scale (VAS) for dyspnea, global quality of life and cough, and number of respiratory rate, night time awaking for dyspnea and cough have been assessed. Results. The scores of VAS for dyspnea, cough and quality of life and also respiratory rate, heart rate, and night time awaking due to dyspnea and night time awaking due to cough improved significantly after morphine nebulization without any major adverse events. Also pick expiratory flow has been improved significantly after nebulization in each day. Conclusion. Our results showed the clinical benefit of nebulized morphine on respiratory complaints of patients due to exposure to SM without significant side effects.http://dx.doi.org/10.1155/2012/610921 |
| spellingShingle | Majid Shohrati Mostafa Ghanei Asghar Amini Harandi Soniya Foroghi Ali Amini Harandi Effect of Nebulized Morphine on Dyspnea of Mustard Gas-Exposed Patients: A Double-Blind Randomized Clinical Trial Study Pulmonary Medicine |
| title | Effect of Nebulized Morphine on Dyspnea of Mustard Gas-Exposed Patients: A Double-Blind Randomized Clinical Trial Study |
| title_full | Effect of Nebulized Morphine on Dyspnea of Mustard Gas-Exposed Patients: A Double-Blind Randomized Clinical Trial Study |
| title_fullStr | Effect of Nebulized Morphine on Dyspnea of Mustard Gas-Exposed Patients: A Double-Blind Randomized Clinical Trial Study |
| title_full_unstemmed | Effect of Nebulized Morphine on Dyspnea of Mustard Gas-Exposed Patients: A Double-Blind Randomized Clinical Trial Study |
| title_short | Effect of Nebulized Morphine on Dyspnea of Mustard Gas-Exposed Patients: A Double-Blind Randomized Clinical Trial Study |
| title_sort | effect of nebulized morphine on dyspnea of mustard gas exposed patients a double blind randomized clinical trial study |
| url | http://dx.doi.org/10.1155/2012/610921 |
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