Liver Transplantation for Acute Liver Failure at 11-Week Gestation with Successful Maternal and Fetal Outcome
Acute liver failure (ALF) during pregnancy is very uncommon. Pregnancy-specific liver conditions like hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and acute fatty liver of pregnancy can cause ALF at term or postpartum, but, typically occur during the third trimester. Most o...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/484080 |
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| author | Vinaya C. Maddukuri Courtney D. Stephenson Lon Eskind William A. Ahrens Preston Purdum Mark W. Russo |
| author_facet | Vinaya C. Maddukuri Courtney D. Stephenson Lon Eskind William A. Ahrens Preston Purdum Mark W. Russo |
| author_sort | Vinaya C. Maddukuri |
| collection | DOAJ |
| description | Acute liver failure (ALF) during pregnancy is very uncommon. Pregnancy-specific liver conditions like hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and acute fatty liver of pregnancy can cause ALF at term or postpartum, but, typically occur during the third trimester. Most of these patients recover spontaneously after delivery, but, on occasion, they require liver transplantation in the postpartum period. However, ALF during the first and second trimester of pregnancy requiring antepartum liver transplantation is rare. Only fifteen cases of liver transplantation during pregnancy have been reported, and very few occurred during the first trimester. We report a Woman who developed acute liver failure during the first trimester of pregnancy and underwent successful liver transplantation at 11-week gestation, followed by successful delivery of the fetus at 30 weeks. To our knowledge, this is the earliest case of successful liver transplantation during pregnancy followed by successful fetal outcome. We discuss management of the patient and fetus before, during, and after liver transplantation and review the literature on antepartum liver transplant in pregnancy. |
| format | Article |
| id | doaj-art-6841251af1ae48c580a514730e12805e |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-6841251af1ae48c580a514730e12805e2025-02-03T01:09:38ZengWileyCase Reports in Transplantation2090-69432090-69512012-01-01201210.1155/2012/484080484080Liver Transplantation for Acute Liver Failure at 11-Week Gestation with Successful Maternal and Fetal OutcomeVinaya C. Maddukuri0Courtney D. Stephenson1Lon Eskind2William A. Ahrens3Preston Purdum4Mark W. Russo5Division of Hepatology, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USADepartment of Obstetrics and Gynecology, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USADepartment of Surgery, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USADepartment of Pathology, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USACarolinas Digestive Health Associates, Charlotte, NC 28211, USADivision of Hepatology, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USAAcute liver failure (ALF) during pregnancy is very uncommon. Pregnancy-specific liver conditions like hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and acute fatty liver of pregnancy can cause ALF at term or postpartum, but, typically occur during the third trimester. Most of these patients recover spontaneously after delivery, but, on occasion, they require liver transplantation in the postpartum period. However, ALF during the first and second trimester of pregnancy requiring antepartum liver transplantation is rare. Only fifteen cases of liver transplantation during pregnancy have been reported, and very few occurred during the first trimester. We report a Woman who developed acute liver failure during the first trimester of pregnancy and underwent successful liver transplantation at 11-week gestation, followed by successful delivery of the fetus at 30 weeks. To our knowledge, this is the earliest case of successful liver transplantation during pregnancy followed by successful fetal outcome. We discuss management of the patient and fetus before, during, and after liver transplantation and review the literature on antepartum liver transplant in pregnancy.http://dx.doi.org/10.1155/2012/484080 |
| spellingShingle | Vinaya C. Maddukuri Courtney D. Stephenson Lon Eskind William A. Ahrens Preston Purdum Mark W. Russo Liver Transplantation for Acute Liver Failure at 11-Week Gestation with Successful Maternal and Fetal Outcome Case Reports in Transplantation |
| title | Liver Transplantation for Acute Liver Failure at 11-Week Gestation with Successful Maternal and Fetal Outcome |
| title_full | Liver Transplantation for Acute Liver Failure at 11-Week Gestation with Successful Maternal and Fetal Outcome |
| title_fullStr | Liver Transplantation for Acute Liver Failure at 11-Week Gestation with Successful Maternal and Fetal Outcome |
| title_full_unstemmed | Liver Transplantation for Acute Liver Failure at 11-Week Gestation with Successful Maternal and Fetal Outcome |
| title_short | Liver Transplantation for Acute Liver Failure at 11-Week Gestation with Successful Maternal and Fetal Outcome |
| title_sort | liver transplantation for acute liver failure at 11 week gestation with successful maternal and fetal outcome |
| url | http://dx.doi.org/10.1155/2012/484080 |
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