Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and Progression
Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long nonc...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/7043509 |
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| author | Manting Choy Yan Guo Hai Li Guohong Wei Runyi Ye Weiwei Liang Haipeng Xiao Yanbing Li Hongyu Guan |
| author_facet | Manting Choy Yan Guo Hai Li Guohong Wei Runyi Ye Weiwei Liang Haipeng Xiao Yanbing Li Hongyu Guan |
| author_sort | Manting Choy |
| collection | DOAJ |
| description | Thyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs), a class of noncoding RNAs (ncRNAs) longer than 200 nucleotides, are aberrantly expressed in malignant diseases, including PTC. Here, we identified a novel isoform of LOC100129940 and designated it as LOC100129940-N. We demonstrated that the expression level of LOC100129940-N was elevated in PTC, indicating that LOC100129940-N may be involved in PTC development and progression. Moreover, our results showed that overexpression of LOC100129940-N promoted, whereas silencing of LOC100129940-N suppressed, PTC cell proliferation, invasion, and migration. Mechanistically, LOC100129940-N played an important role in activating Wnt/β-catenin signaling and upregulating downstream target genes. Taken together, we demonstrate that LOC100129940-N promotes the activation of Wnt/β-catenin signaling, which in turn regulates the downstream target genes, thereby enhancing invasion and progression of PTC. |
| format | Article |
| id | doaj-art-683ec14457304ee8aa2ba1c4be55a097 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-683ec14457304ee8aa2ba1c4be55a0972025-02-03T05:59:18ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/70435097043509Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and ProgressionManting Choy0Yan Guo1Hai Li2Guohong Wei3Runyi Ye4Weiwei Liang5Haipeng Xiao6Yanbing Li7Hongyu Guan8Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, ChinaDepartment of Thyroid and Breast Surgery, The First Affiliated Hospital of Sun Yat-sen University, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, ChinaDepartment of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, ChinaThyroid cancer is the most common endocrine malignancy, and its incidence has increased rapidly in recent decades worldwide. Papillary thyroid cancer (PTC) is the most common type of all thyroid cancers. The molecular mechanisms underlying the disease still need to be further investigated. Long noncoding RNAs (lncRNAs), a class of noncoding RNAs (ncRNAs) longer than 200 nucleotides, are aberrantly expressed in malignant diseases, including PTC. Here, we identified a novel isoform of LOC100129940 and designated it as LOC100129940-N. We demonstrated that the expression level of LOC100129940-N was elevated in PTC, indicating that LOC100129940-N may be involved in PTC development and progression. Moreover, our results showed that overexpression of LOC100129940-N promoted, whereas silencing of LOC100129940-N suppressed, PTC cell proliferation, invasion, and migration. Mechanistically, LOC100129940-N played an important role in activating Wnt/β-catenin signaling and upregulating downstream target genes. Taken together, we demonstrate that LOC100129940-N promotes the activation of Wnt/β-catenin signaling, which in turn regulates the downstream target genes, thereby enhancing invasion and progression of PTC.http://dx.doi.org/10.1155/2019/7043509 |
| spellingShingle | Manting Choy Yan Guo Hai Li Guohong Wei Runyi Ye Weiwei Liang Haipeng Xiao Yanbing Li Hongyu Guan Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and Progression International Journal of Endocrinology |
| title | Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and Progression |
| title_full | Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and Progression |
| title_fullStr | Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and Progression |
| title_full_unstemmed | Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and Progression |
| title_short | Long Noncoding RNA LOC100129940-N Is Upregulated in Papillary Thyroid Cancer and Promotes the Invasion and Progression |
| title_sort | long noncoding rna loc100129940 n is upregulated in papillary thyroid cancer and promotes the invasion and progression |
| url | http://dx.doi.org/10.1155/2019/7043509 |
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