Impact of Deacetylation Degree on Properties of Chitosan for Formation of Electrosprayed Nanoparticles
Biopolymer of natural origin as chitosan has been studied and applied widely in practice. In the pharmaceutical field, especially, chitosan nanoparticles have been researched for a variety of drug delivery systems. There are many factors influencing the success of the chitosan nanoparticle delivery...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2022/2288892 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553682945703936 |
|---|---|
| author | Hien Thi-Thanh Nguyen Tinh Ngoc Tran Anh Cam Ha Phu Dai Huynh |
| author_facet | Hien Thi-Thanh Nguyen Tinh Ngoc Tran Anh Cam Ha Phu Dai Huynh |
| author_sort | Hien Thi-Thanh Nguyen |
| collection | DOAJ |
| description | Biopolymer of natural origin as chitosan has been studied and applied widely in practice. In the pharmaceutical field, especially, chitosan nanoparticles have been researched for a variety of drug delivery systems. There are many factors influencing the success of the chitosan nanoparticle delivery system. Therein, the specific parameters to the physicochemical nature of chitosan greatly determine the efficiency of its drugs carrier. The degree of deacetylation (DD) of chitosan is one of those parameters. In this study, the influence of DD on chitosan properties was clarified to facilitate the preparation of nanoparticles by the electrospraying method. DD can affect the solubility, crystallinity, and surface tension of chitosan, but it cannot strongly impact the viscosity of chitosan solution as much as the molecular weight (Mv). From these results, M3 chitosan, owning a high DD of 86.70%, and crystalline index of 44%, was dissolved in acetic acid for the collection of electrosprayed nanoparticles. The M3 solution having low viscosity of under 50 mm2/s displayed the easy adjustment of the stable Taylor-cone droplet at the nozzle tip. Particularly, the M3 chitosan solution with a concentration of 1.5 wt.% in acetic acid of 90 wt.% concentration operated at the working condition of 12 kV voltage, a distance between the two electrodes of 10 cm created spherical particles with an average diameter of 338 nm, narrow size distribution. These chitosan nanoparticles can obtain the initial requirement for application as injectable drugs carrier. |
| format | Article |
| id | doaj-art-682f32e7f8b145dfa6b43504f4fa87a9 |
| institution | Kabale University |
| issn | 1687-9511 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-682f32e7f8b145dfa6b43504f4fa87a92025-02-03T05:53:27ZengWileyJournal of Nanotechnology1687-95112022-01-01202210.1155/2022/2288892Impact of Deacetylation Degree on Properties of Chitosan for Formation of Electrosprayed NanoparticlesHien Thi-Thanh Nguyen0Tinh Ngoc Tran1Anh Cam Ha2Phu Dai Huynh3Vietnam National University Ho Chi Minh CityFaculty of Chemical EngineeringVietnam National University Ho Chi Minh CityVietnam National University Ho Chi Minh CityBiopolymer of natural origin as chitosan has been studied and applied widely in practice. In the pharmaceutical field, especially, chitosan nanoparticles have been researched for a variety of drug delivery systems. There are many factors influencing the success of the chitosan nanoparticle delivery system. Therein, the specific parameters to the physicochemical nature of chitosan greatly determine the efficiency of its drugs carrier. The degree of deacetylation (DD) of chitosan is one of those parameters. In this study, the influence of DD on chitosan properties was clarified to facilitate the preparation of nanoparticles by the electrospraying method. DD can affect the solubility, crystallinity, and surface tension of chitosan, but it cannot strongly impact the viscosity of chitosan solution as much as the molecular weight (Mv). From these results, M3 chitosan, owning a high DD of 86.70%, and crystalline index of 44%, was dissolved in acetic acid for the collection of electrosprayed nanoparticles. The M3 solution having low viscosity of under 50 mm2/s displayed the easy adjustment of the stable Taylor-cone droplet at the nozzle tip. Particularly, the M3 chitosan solution with a concentration of 1.5 wt.% in acetic acid of 90 wt.% concentration operated at the working condition of 12 kV voltage, a distance between the two electrodes of 10 cm created spherical particles with an average diameter of 338 nm, narrow size distribution. These chitosan nanoparticles can obtain the initial requirement for application as injectable drugs carrier.http://dx.doi.org/10.1155/2022/2288892 |
| spellingShingle | Hien Thi-Thanh Nguyen Tinh Ngoc Tran Anh Cam Ha Phu Dai Huynh Impact of Deacetylation Degree on Properties of Chitosan for Formation of Electrosprayed Nanoparticles Journal of Nanotechnology |
| title | Impact of Deacetylation Degree on Properties of Chitosan for Formation of Electrosprayed Nanoparticles |
| title_full | Impact of Deacetylation Degree on Properties of Chitosan for Formation of Electrosprayed Nanoparticles |
| title_fullStr | Impact of Deacetylation Degree on Properties of Chitosan for Formation of Electrosprayed Nanoparticles |
| title_full_unstemmed | Impact of Deacetylation Degree on Properties of Chitosan for Formation of Electrosprayed Nanoparticles |
| title_short | Impact of Deacetylation Degree on Properties of Chitosan for Formation of Electrosprayed Nanoparticles |
| title_sort | impact of deacetylation degree on properties of chitosan for formation of electrosprayed nanoparticles |
| url | http://dx.doi.org/10.1155/2022/2288892 |
| work_keys_str_mv | AT hienthithanhnguyen impactofdeacetylationdegreeonpropertiesofchitosanforformationofelectrosprayednanoparticles AT tinhngoctran impactofdeacetylationdegreeonpropertiesofchitosanforformationofelectrosprayednanoparticles AT anhcamha impactofdeacetylationdegreeonpropertiesofchitosanforformationofelectrosprayednanoparticles AT phudaihuynh impactofdeacetylationdegreeonpropertiesofchitosanforformationofelectrosprayednanoparticles |