Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by Limiting pyroptosisResearch in context

Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by Limiting pyroptosisResearch in context

Summary: Background: Acute kidney injury (AKI) is a critical clinical syndrome with high morbidity, mortality, and no effective treatment in clinical practice. The role of the Signal Transducer and Activator of Transcription 3 (Stat3) in AKI remains controversial, and its complex regulatory mechani...

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Main Authors: Ming-lu Ji, Jia-nan Wang, Ming-fei Wu, Chuan-hui Xu, Meng-meng Zhang, Wen-bao Chang, Xin-fei Mao, Chao Li, Ju-tao Yu, Dan-feng Zhang, Xiao-guo Suo, Shao-xi Diao, Nan-nan Ma, Ying Chen, Rui Hou, Hao Lu, Shuai-shuai Xie, Yu-hang Dong, Qi Zhu, Xin Chen, Tao Xu, Wei Shao, Juan Jin, Jia-gen Wen, Xiao-wu Dong, Wen-bin Wang, Jin-xin Che, Xiao-ming Meng
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:EBioMedicine
Subjects:
Stat3
Histone modification
Pyroptosis
Renal injury
PROTAC
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425001835
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