Use of 5-Fluorouracil-Soaked Bioamniotic Membranes in Trabeculectomy for Primary Open-Angle Glaucoma: A Retrospective Analysis
The study is a retrospective analysis of 51 patients (76 eyes) with primary open-angle glaucoma (POAG) who admitted to our hospital from 2008 to 2010 to analyze the efficacy of trabeculectomy in combination with 5-fluorouracil- (5-FU-) soaked amniotic membranes for the treatment of POAG patients. Am...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/2698975 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545857042382848 |
|---|---|
| author | Chenming Zhang Min Wu Jianrong Wang Miaomiao Zhang Xu Wang Wei Liu |
| author_facet | Chenming Zhang Min Wu Jianrong Wang Miaomiao Zhang Xu Wang Wei Liu |
| author_sort | Chenming Zhang |
| collection | DOAJ |
| description | The study is a retrospective analysis of 51 patients (76 eyes) with primary open-angle glaucoma (POAG) who admitted to our hospital from 2008 to 2010 to analyze the efficacy of trabeculectomy in combination with 5-fluorouracil- (5-FU-) soaked amniotic membranes for the treatment of POAG patients. Among them, 30 patients (41 eyes) were treated with trabeculectomy in combination with 5-FU-soaked amniotic membrane and 21 patients (35 eyes) were treated with trabeculectomy in combination with MMC. Preoperative and postoperative intraocular pressures (IOP), cup/disc ratio, visual acuity and postoperative macular OCT, complications, treatment, and number of corneal endothelial cells were measured, recorded, and analyzed. At the end of 2 years of follow-up, IOP of 36 (87.8%) eyes of patients in the 5-FU group and IOP of 28 (80%) eyes of patients in the MMC group were ≤21 mmHg and patients in the 5-FU group had more stable IOP than patients in the MMC group. During the two years of follow-up, the visual acuity of 22 (53.7%) eyes in the 5-FU group remained unchanged or even improved. Trabeculectomy in combination with 5-FU-soaked biological amniotic membranes can be a surgical option for POAG patients. |
| format | Article |
| id | doaj-art-680844800c8545c79e25cb170449d99e |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-680844800c8545c79e25cb170449d99e2025-02-03T07:24:37ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/26989752698975Use of 5-Fluorouracil-Soaked Bioamniotic Membranes in Trabeculectomy for Primary Open-Angle Glaucoma: A Retrospective AnalysisChenming Zhang0Min Wu1Jianrong Wang2Miaomiao Zhang3Xu Wang4Wei Liu5Eye Research Institute, Jinan Eye Hospital, No. 148 Jingyi Road, Jinan, Shandong 250001, ChinaEye Research Institute, Jinan Eye Hospital, No. 148 Jingyi Road, Jinan, Shandong 250001, ChinaEye Research Institute, Jinan Eye Hospital, No. 148 Jingyi Road, Jinan, Shandong 250001, ChinaEye Research Institute, Jinan Eye Hospital, No. 148 Jingyi Road, Jinan, Shandong 250001, ChinaEye Research Institute, Jinan Eye Hospital, No. 148 Jingyi Road, Jinan, Shandong 250001, ChinaEye Research Institute, Jinan Eye Hospital, No. 148 Jingyi Road, Jinan, Shandong 250001, ChinaThe study is a retrospective analysis of 51 patients (76 eyes) with primary open-angle glaucoma (POAG) who admitted to our hospital from 2008 to 2010 to analyze the efficacy of trabeculectomy in combination with 5-fluorouracil- (5-FU-) soaked amniotic membranes for the treatment of POAG patients. Among them, 30 patients (41 eyes) were treated with trabeculectomy in combination with 5-FU-soaked amniotic membrane and 21 patients (35 eyes) were treated with trabeculectomy in combination with MMC. Preoperative and postoperative intraocular pressures (IOP), cup/disc ratio, visual acuity and postoperative macular OCT, complications, treatment, and number of corneal endothelial cells were measured, recorded, and analyzed. At the end of 2 years of follow-up, IOP of 36 (87.8%) eyes of patients in the 5-FU group and IOP of 28 (80%) eyes of patients in the MMC group were ≤21 mmHg and patients in the 5-FU group had more stable IOP than patients in the MMC group. During the two years of follow-up, the visual acuity of 22 (53.7%) eyes in the 5-FU group remained unchanged or even improved. Trabeculectomy in combination with 5-FU-soaked biological amniotic membranes can be a surgical option for POAG patients.http://dx.doi.org/10.1155/2017/2698975 |
| spellingShingle | Chenming Zhang Min Wu Jianrong Wang Miaomiao Zhang Xu Wang Wei Liu Use of 5-Fluorouracil-Soaked Bioamniotic Membranes in Trabeculectomy for Primary Open-Angle Glaucoma: A Retrospective Analysis Journal of Ophthalmology |
| title | Use of 5-Fluorouracil-Soaked Bioamniotic Membranes in Trabeculectomy for Primary Open-Angle Glaucoma: A Retrospective Analysis |
| title_full | Use of 5-Fluorouracil-Soaked Bioamniotic Membranes in Trabeculectomy for Primary Open-Angle Glaucoma: A Retrospective Analysis |
| title_fullStr | Use of 5-Fluorouracil-Soaked Bioamniotic Membranes in Trabeculectomy for Primary Open-Angle Glaucoma: A Retrospective Analysis |
| title_full_unstemmed | Use of 5-Fluorouracil-Soaked Bioamniotic Membranes in Trabeculectomy for Primary Open-Angle Glaucoma: A Retrospective Analysis |
| title_short | Use of 5-Fluorouracil-Soaked Bioamniotic Membranes in Trabeculectomy for Primary Open-Angle Glaucoma: A Retrospective Analysis |
| title_sort | use of 5 fluorouracil soaked bioamniotic membranes in trabeculectomy for primary open angle glaucoma a retrospective analysis |
| url | http://dx.doi.org/10.1155/2017/2698975 |
| work_keys_str_mv | AT chenmingzhang useof5fluorouracilsoakedbioamnioticmembranesintrabeculectomyforprimaryopenangleglaucomaaretrospectiveanalysis AT minwu useof5fluorouracilsoakedbioamnioticmembranesintrabeculectomyforprimaryopenangleglaucomaaretrospectiveanalysis AT jianrongwang useof5fluorouracilsoakedbioamnioticmembranesintrabeculectomyforprimaryopenangleglaucomaaretrospectiveanalysis AT miaomiaozhang useof5fluorouracilsoakedbioamnioticmembranesintrabeculectomyforprimaryopenangleglaucomaaretrospectiveanalysis AT xuwang useof5fluorouracilsoakedbioamnioticmembranesintrabeculectomyforprimaryopenangleglaucomaaretrospectiveanalysis AT weiliu useof5fluorouracilsoakedbioamnioticmembranesintrabeculectomyforprimaryopenangleglaucomaaretrospectiveanalysis |