Is Vitamin D Deficiency the Cause or the Effect of Systemic Lupus Erythematosus: Evidence from Bidirectional Mendelian Randomization Analysis
Background. Vitamin D deficiency is common in patients with systemic lupus erythematosus (SLE). Observational studies have reported that it is associated with SLE. In this bidirectional Mendelian randomization (MR) study, we explored the genetic association between serum vitamin D (VD) levels and SL...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/8689777 |
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| author | Yang Ding Shengyi Yang Shasha Fan Yi Tang Yan Teng Xiaohua Tao Wei Lu |
| author_facet | Yang Ding Shengyi Yang Shasha Fan Yi Tang Yan Teng Xiaohua Tao Wei Lu |
| author_sort | Yang Ding |
| collection | DOAJ |
| description | Background. Vitamin D deficiency is common in patients with systemic lupus erythematosus (SLE). Observational studies have reported that it is associated with SLE. In this bidirectional Mendelian randomization (MR) study, we explored the genetic association between serum vitamin D (VD) levels and SLE using two models. Methods. Genetic variants associated with vitamin D (n=304,181), 25-hydroxyvitamin D levels (n=401,460), and SLE (n=213,683) at genome-wide significance (P<5∗10−8) derived from large-scale publicly available GWAS data were used as instrumental variables. Bidirectional two-sample MR analyses were performed using the inverse variance weighted method (IVW, random, or fixed effect model). Sensitivity analyses including maximum likelihood, MR-Egger method, penalized weighted median method, MR-PRESSO, MR-RAPS, and MR-radial method were conducted. Results. The findings showed that genetically predicted SLE using the IVW method had a negative effect on the vitamin D and 25-hydroxyvitamin D levels in the two models. The results of sensitivity analyses of different analytical approaches were consistent. Conclusions. These findings indicated that genetically determined SLE had a negative effect on the vitamin D and 25-hydroxyvitamin D levels. Future studies, including random controlled clinical trials, should evaluate the association and mechanisms between serum VD levels and SLE. |
| format | Article |
| id | doaj-art-67f2bc8dbb1f4a38a4b7c62bd72ab6b3 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-67f2bc8dbb1f4a38a4b7c62bd72ab6b32025-02-03T06:08:46ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/8689777Is Vitamin D Deficiency the Cause or the Effect of Systemic Lupus Erythematosus: Evidence from Bidirectional Mendelian Randomization AnalysisYang Ding0Shengyi Yang1Shasha Fan2Yi Tang3Yan Teng4Xiaohua Tao5Wei Lu6Health Management CenterKey Laboratory of Environmental Medicine EngineeringHealth Management CenterHealth Management CenterHealth Management CenterHealth Management CenterHealth Management CenterBackground. Vitamin D deficiency is common in patients with systemic lupus erythematosus (SLE). Observational studies have reported that it is associated with SLE. In this bidirectional Mendelian randomization (MR) study, we explored the genetic association between serum vitamin D (VD) levels and SLE using two models. Methods. Genetic variants associated with vitamin D (n=304,181), 25-hydroxyvitamin D levels (n=401,460), and SLE (n=213,683) at genome-wide significance (P<5∗10−8) derived from large-scale publicly available GWAS data were used as instrumental variables. Bidirectional two-sample MR analyses were performed using the inverse variance weighted method (IVW, random, or fixed effect model). Sensitivity analyses including maximum likelihood, MR-Egger method, penalized weighted median method, MR-PRESSO, MR-RAPS, and MR-radial method were conducted. Results. The findings showed that genetically predicted SLE using the IVW method had a negative effect on the vitamin D and 25-hydroxyvitamin D levels in the two models. The results of sensitivity analyses of different analytical approaches were consistent. Conclusions. These findings indicated that genetically determined SLE had a negative effect on the vitamin D and 25-hydroxyvitamin D levels. Future studies, including random controlled clinical trials, should evaluate the association and mechanisms between serum VD levels and SLE.http://dx.doi.org/10.1155/2022/8689777 |
| spellingShingle | Yang Ding Shengyi Yang Shasha Fan Yi Tang Yan Teng Xiaohua Tao Wei Lu Is Vitamin D Deficiency the Cause or the Effect of Systemic Lupus Erythematosus: Evidence from Bidirectional Mendelian Randomization Analysis Journal of Immunology Research |
| title | Is Vitamin D Deficiency the Cause or the Effect of Systemic Lupus Erythematosus: Evidence from Bidirectional Mendelian Randomization Analysis |
| title_full | Is Vitamin D Deficiency the Cause or the Effect of Systemic Lupus Erythematosus: Evidence from Bidirectional Mendelian Randomization Analysis |
| title_fullStr | Is Vitamin D Deficiency the Cause or the Effect of Systemic Lupus Erythematosus: Evidence from Bidirectional Mendelian Randomization Analysis |
| title_full_unstemmed | Is Vitamin D Deficiency the Cause or the Effect of Systemic Lupus Erythematosus: Evidence from Bidirectional Mendelian Randomization Analysis |
| title_short | Is Vitamin D Deficiency the Cause or the Effect of Systemic Lupus Erythematosus: Evidence from Bidirectional Mendelian Randomization Analysis |
| title_sort | is vitamin d deficiency the cause or the effect of systemic lupus erythematosus evidence from bidirectional mendelian randomization analysis |
| url | http://dx.doi.org/10.1155/2022/8689777 |
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