Exosomal insights into ovarian cancer stem cells: revealing the molecular hubs
Abstract Ovarian cancer is a deadly disease, often diagnosed at advanced stages due to a lack of reliable biomarkers. Exosomes, which carry a variety of molecules such as proteins, lipids, DNA, and non-coding RNAs, have recently emerged as promising tools for early cancer detection. While exosomes h...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Ovarian Research |
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| Online Access: | https://doi.org/10.1186/s13048-025-01597-3 |
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| author | Kiana Sojoudi Maryam Solaimani Hossein Azizi |
| author_facet | Kiana Sojoudi Maryam Solaimani Hossein Azizi |
| author_sort | Kiana Sojoudi |
| collection | DOAJ |
| description | Abstract Ovarian cancer is a deadly disease, often diagnosed at advanced stages due to a lack of reliable biomarkers. Exosomes, which carry a variety of molecules such as proteins, lipids, DNA, and non-coding RNAs, have recently emerged as promising tools for early cancer detection. While exosomes have been studied in various cancer types, comprehensive network analyses of exosome proteins in ovarian cancer remain limited. In this study, we used a protein-protein interaction (PPI) network. Using the Clustermaker2 app and the MCODE algorithm, we identified six significant clusters within the network, highlighting regions involved in functional pathways. A four-fold algorithmic approach, including MCC, DMNC, Degree, and EPC, identified 12 common hub genes. STRING analysis and visualization techniques provided a detailed understanding of the biological processes associated with these hub genes. Notably, 91.7% of the identified hub genes were involved in translational processes, showing an important role in protein synthesis regulation in ovarian cancer. In addition, we identified the miRNAs and LncRNAs carried by ovarian cancer exosomes. These findings highlight potential biomarkers for early detection and therapeutic targets. |
| format | Article |
| id | doaj-art-67ed701fb1dc4bf58718fed5630a2d1a |
| institution | Kabale University |
| issn | 1757-2215 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj-art-67ed701fb1dc4bf58718fed5630a2d1a2025-02-02T12:36:59ZengBMCJournal of Ovarian Research1757-22152025-01-0118111310.1186/s13048-025-01597-3Exosomal insights into ovarian cancer stem cells: revealing the molecular hubsKiana Sojoudi0Maryam Solaimani1Hossein Azizi2Department of Biology, Faculty of Sciences, University of GuilanFaculty of Biotechnology, Amol University of Special Modern TechnologiesFaculty of Biotechnology, Amol University of Special Modern TechnologiesAbstract Ovarian cancer is a deadly disease, often diagnosed at advanced stages due to a lack of reliable biomarkers. Exosomes, which carry a variety of molecules such as proteins, lipids, DNA, and non-coding RNAs, have recently emerged as promising tools for early cancer detection. While exosomes have been studied in various cancer types, comprehensive network analyses of exosome proteins in ovarian cancer remain limited. In this study, we used a protein-protein interaction (PPI) network. Using the Clustermaker2 app and the MCODE algorithm, we identified six significant clusters within the network, highlighting regions involved in functional pathways. A four-fold algorithmic approach, including MCC, DMNC, Degree, and EPC, identified 12 common hub genes. STRING analysis and visualization techniques provided a detailed understanding of the biological processes associated with these hub genes. Notably, 91.7% of the identified hub genes were involved in translational processes, showing an important role in protein synthesis regulation in ovarian cancer. In addition, we identified the miRNAs and LncRNAs carried by ovarian cancer exosomes. These findings highlight potential biomarkers for early detection and therapeutic targets.https://doi.org/10.1186/s13048-025-01597-3Ovarian cancerExosomeCytoscapePPI networkSTRING |
| spellingShingle | Kiana Sojoudi Maryam Solaimani Hossein Azizi Exosomal insights into ovarian cancer stem cells: revealing the molecular hubs Journal of Ovarian Research Ovarian cancer Exosome Cytoscape PPI network STRING |
| title | Exosomal insights into ovarian cancer stem cells: revealing the molecular hubs |
| title_full | Exosomal insights into ovarian cancer stem cells: revealing the molecular hubs |
| title_fullStr | Exosomal insights into ovarian cancer stem cells: revealing the molecular hubs |
| title_full_unstemmed | Exosomal insights into ovarian cancer stem cells: revealing the molecular hubs |
| title_short | Exosomal insights into ovarian cancer stem cells: revealing the molecular hubs |
| title_sort | exosomal insights into ovarian cancer stem cells revealing the molecular hubs |
| topic | Ovarian cancer Exosome Cytoscape PPI network STRING |
| url | https://doi.org/10.1186/s13048-025-01597-3 |
| work_keys_str_mv | AT kianasojoudi exosomalinsightsintoovariancancerstemcellsrevealingthemolecularhubs AT maryamsolaimani exosomalinsightsintoovariancancerstemcellsrevealingthemolecularhubs AT hosseinazizi exosomalinsightsintoovariancancerstemcellsrevealingthemolecularhubs |