Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and Fusion
This study was conducted to validate the safety and efficiency of biomimetic nanohydroxyapatite/polyamide 66 (n-HA/PA66) composite in animal model (rabbit) and report its application in anterior cervical discectomy and fusion (ACDF) for 4, 12, and 24 weeks. N-HA/PA66 composite was implanted into one...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2014/696045 |
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| author | Hui Xu Yan Wang Xiaojing Su Xuelian Zhang Xuesong Zhang |
| author_facet | Hui Xu Yan Wang Xiaojing Su Xuelian Zhang Xuesong Zhang |
| author_sort | Hui Xu |
| collection | DOAJ |
| description | This study was conducted to validate the safety and efficiency of biomimetic nanohydroxyapatite/polyamide 66 (n-HA/PA66) composite in animal model (rabbit) and report its application in anterior cervical discectomy and fusion (ACDF) for 4, 12, and 24 weeks. N-HA/PA66 composite was implanted into one-side hind femur defects and the control defects were kept empty as blank controls. A combination of macroscopic and histomorphometric studies was performed up to 24 weeks postoperatively and compared with normal healing. 60 cervical spondylosis myelopathy and radiculopathy patients who were subjected to ACDF using n-HA/PA66 and PEEK cage were involved in this study with six-month minimum follow-up. Their radiographic (cage subsidence, fusion status, and segmental sagittal alignment (SSA)) and clinical (VAS and JOA scales) data before surgery and at each follow-up were recorded and compared. Nanohydroxyapatite/polyamide 66 composite is safe and effective in animal experiment and ACDF. |
| format | Article |
| id | doaj-art-67e97eba7f59417ea41c37ef8af113c6 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-67e97eba7f59417ea41c37ef8af113c62025-02-03T05:51:26ZengWileyInternational Journal of Polymer Science1687-94221687-94302014-01-01201410.1155/2014/696045696045Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and FusionHui Xu0Yan Wang1Xiaojing Su2Xuelian Zhang3Xuesong Zhang4Department of Orthopedics, Liaocheng People’s Hospital, 67 Dongchang West Road, Liaocheng, Shandong 252004, ChinaDepartment of Orthopedics, Chinese People’s Liberation Army General Hospital, Beijing 100853, ChinaDepartment of Orthopedics, Chinese People’s Liberation Army General Hospital, Beijing 100853, ChinaDepartment of Endocrinology, China-Japan Friendship Hospital, Beijing 100029, ChinaDepartment of Orthopedics, Chinese People’s Liberation Army General Hospital, Beijing 100853, ChinaThis study was conducted to validate the safety and efficiency of biomimetic nanohydroxyapatite/polyamide 66 (n-HA/PA66) composite in animal model (rabbit) and report its application in anterior cervical discectomy and fusion (ACDF) for 4, 12, and 24 weeks. N-HA/PA66 composite was implanted into one-side hind femur defects and the control defects were kept empty as blank controls. A combination of macroscopic and histomorphometric studies was performed up to 24 weeks postoperatively and compared with normal healing. 60 cervical spondylosis myelopathy and radiculopathy patients who were subjected to ACDF using n-HA/PA66 and PEEK cage were involved in this study with six-month minimum follow-up. Their radiographic (cage subsidence, fusion status, and segmental sagittal alignment (SSA)) and clinical (VAS and JOA scales) data before surgery and at each follow-up were recorded and compared. Nanohydroxyapatite/polyamide 66 composite is safe and effective in animal experiment and ACDF.http://dx.doi.org/10.1155/2014/696045 |
| spellingShingle | Hui Xu Yan Wang Xiaojing Su Xuelian Zhang Xuesong Zhang Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and Fusion International Journal of Polymer Science |
| title | Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and Fusion |
| title_full | Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and Fusion |
| title_fullStr | Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and Fusion |
| title_full_unstemmed | Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and Fusion |
| title_short | Safety and Efficiency of Biomimetic Nanohydroxyapatite/Polyamide 66 Composite in Rabbits and Primary Use in Anterior Cervical Discectomy and Fusion |
| title_sort | safety and efficiency of biomimetic nanohydroxyapatite polyamide 66 composite in rabbits and primary use in anterior cervical discectomy and fusion |
| url | http://dx.doi.org/10.1155/2014/696045 |
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