Probiotics for Alleviating Alcoholic Liver Injury
Many animal experiments and clinical trials showed that probiotics are effective for the treatment of alcoholic liver disease. Alcohol disrupts the composition of intestinal flora; probiotics modulate the gut microbiota and reverse alcohol-associated intestinal barrier dysfunction by decreasing inte...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/9097276 |
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| _version_ | 1832551735727489024 |
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| author | Zelin Gu Yanlong Liu Shumeng Hu Ying You Jiaqi Wen Wancong Li Yuhua Wang |
| author_facet | Zelin Gu Yanlong Liu Shumeng Hu Ying You Jiaqi Wen Wancong Li Yuhua Wang |
| author_sort | Zelin Gu |
| collection | DOAJ |
| description | Many animal experiments and clinical trials showed that probiotics are effective for the treatment of alcoholic liver disease. Alcohol disrupts the composition of intestinal flora; probiotics modulate the gut microbiota and reverse alcohol-associated intestinal barrier dysfunction by decreasing intestinal mucosal permeability and preventing intestinal bacteria from translocating. Probiotics enhance immune responses and reduce the levels of alcohol-induced inflammatory cytokines and reactive oxygen species (ROS) production in the liver and intestine. Probiotics also increase fatty acid β-oxidation and reduce lipogenesis, combating alcohol-induced hepatic steatosis. In this review, we summarize the current knowledge regarding the mechanism of action of probiotics for reducing the effects of alcoholic liver disease. |
| format | Article |
| id | doaj-art-67e713cc15674a12acea1d382f12a75f |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-67e713cc15674a12acea1d382f12a75f2025-02-03T06:00:42ZengWileyGastroenterology Research and Practice1687-61211687-630X2019-01-01201910.1155/2019/90972769097276Probiotics for Alleviating Alcoholic Liver InjuryZelin Gu0Yanlong Liu1Shumeng Hu2Ying You3Jiaqi Wen4Wancong Li5Yuhua Wang6College of Food Science and Engineering, Jilin Agricultural University, Changchun, ChinaCollege of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, ChinaMany animal experiments and clinical trials showed that probiotics are effective for the treatment of alcoholic liver disease. Alcohol disrupts the composition of intestinal flora; probiotics modulate the gut microbiota and reverse alcohol-associated intestinal barrier dysfunction by decreasing intestinal mucosal permeability and preventing intestinal bacteria from translocating. Probiotics enhance immune responses and reduce the levels of alcohol-induced inflammatory cytokines and reactive oxygen species (ROS) production in the liver and intestine. Probiotics also increase fatty acid β-oxidation and reduce lipogenesis, combating alcohol-induced hepatic steatosis. In this review, we summarize the current knowledge regarding the mechanism of action of probiotics for reducing the effects of alcoholic liver disease.http://dx.doi.org/10.1155/2019/9097276 |
| spellingShingle | Zelin Gu Yanlong Liu Shumeng Hu Ying You Jiaqi Wen Wancong Li Yuhua Wang Probiotics for Alleviating Alcoholic Liver Injury Gastroenterology Research and Practice |
| title | Probiotics for Alleviating Alcoholic Liver Injury |
| title_full | Probiotics for Alleviating Alcoholic Liver Injury |
| title_fullStr | Probiotics for Alleviating Alcoholic Liver Injury |
| title_full_unstemmed | Probiotics for Alleviating Alcoholic Liver Injury |
| title_short | Probiotics for Alleviating Alcoholic Liver Injury |
| title_sort | probiotics for alleviating alcoholic liver injury |
| url | http://dx.doi.org/10.1155/2019/9097276 |
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