Plasma galectin-3 is associated with decreased glomerular filtration rate in chronic HIV
Background People living with HIV (PLWH) have higher rates of chronic kidney disease (CKD) compared with HIV-uninfected individuals. The pathogenesis of CKD in HIV remains poorly understood but is likely from a combination of various factors, such as traditional comorbidities, prolonged antiretrovir...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | HIV Research & Clinical Practice |
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| Online Access: | http://dx.doi.org/10.1080/25787489.2023.2261753 |
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| author | Diana L. Vares-Lum Louie Mar A. Gangcuangco Juwon Park Eduardo Manzano Michael Ortega Dominic C. Chow Cecilia Shikuma |
| author_facet | Diana L. Vares-Lum Louie Mar A. Gangcuangco Juwon Park Eduardo Manzano Michael Ortega Dominic C. Chow Cecilia Shikuma |
| author_sort | Diana L. Vares-Lum |
| collection | DOAJ |
| description | Background People living with HIV (PLWH) have higher rates of chronic kidney disease (CKD) compared with HIV-uninfected individuals. The pathogenesis of CKD in HIV remains poorly understood but is likely from a combination of various factors, such as traditional comorbidities, prolonged antiretroviral therapy, immune dysregulation, and direct HIV effect on the kidneys. We evaluated plasma galectin-3 (Gal-3), a circulating marker of fibrosis, and its association with renal function. Methods Estimated glomerular filtration rate (eGFR) was assessed by CKD-EPI. Plasma galectin-3 was obtained from banked specimens by ELISA. Factors associated with eGFR were analyzed using step-wise multiple linear regression. Results A total of 45 PLWH and 58 HIV-uninfected participants were included with similar demographic parameters. Among PLWH, majority had undetectable plasma HIV RNA (82.2%). Gal-3 was significantly higher in PLWH than in HIV-uninfected participants (6.4 [IQR 4.0, 8.5] ng/mL and 4.5 [IQR 2.3, 6.5] ng/mL, respectively; p = 0.020) while a trend towards lower eGFR was found in PLWH compared to the HIV-uninfected cohort (86.8 [IQR 71.3, 91.8] and 89.0 [IQR 78.6, 97.4] mL/min/1.73 m2, respectively; p = 0.071). In univariable analysis, HIV status was marginally associated with decreased eGFR (β coefficient= −0.035, p = 0.051). In the final multivariable regression model adjusted for traditional risk factors of CKD, Gal-3 independently predicted a decrease in eGFR (unstandardized B= −0.008, p < 0.001) while HIV status did not demonstrate any significant association. Conclusion Gal-3 was higher in PLWH compared with HIV-uninfected participants. In multivariable adjusted analyses, Gal-3, but not HIV status, was associated with decreased eGFR. The role of Gal-3 as a biomarker of kidney function needs to be further elucidated. |
| format | Article |
| id | doaj-art-67c036d54224471b902b3f6e696cb83c |
| institution | Kabale University |
| issn | 2578-7470 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | HIV Research & Clinical Practice |
| spelling | doaj-art-67c036d54224471b902b3f6e696cb83c2025-01-20T14:37:59ZengTaylor & Francis GroupHIV Research & Clinical Practice2578-74702023-12-0124110.1080/25787489.2023.22617532261753Plasma galectin-3 is associated with decreased glomerular filtration rate in chronic HIVDiana L. Vares-Lum0Louie Mar A. Gangcuangco1Juwon Park2Eduardo Manzano3Michael Ortega4Dominic C. Chow5Cecilia Shikuma6Hawaii Center for AIDS, John A Burns School of Medicine, University of HawaiiHawaii Center for AIDS, John A Burns School of Medicine, University of HawaiiHawaii Center for AIDS, John A Burns School of Medicine, University of HawaiiHawaii Center for AIDS, John A Burns School of Medicine, University of HawaiiCenter for Biomedical Research, The Queen’s Medical CenterHawaii Center for AIDS, John A Burns School of Medicine, University of HawaiiHawaii Center for AIDS, John A Burns School of Medicine, University of HawaiiBackground People living with HIV (PLWH) have higher rates of chronic kidney disease (CKD) compared with HIV-uninfected individuals. The pathogenesis of CKD in HIV remains poorly understood but is likely from a combination of various factors, such as traditional comorbidities, prolonged antiretroviral therapy, immune dysregulation, and direct HIV effect on the kidneys. We evaluated plasma galectin-3 (Gal-3), a circulating marker of fibrosis, and its association with renal function. Methods Estimated glomerular filtration rate (eGFR) was assessed by CKD-EPI. Plasma galectin-3 was obtained from banked specimens by ELISA. Factors associated with eGFR were analyzed using step-wise multiple linear regression. Results A total of 45 PLWH and 58 HIV-uninfected participants were included with similar demographic parameters. Among PLWH, majority had undetectable plasma HIV RNA (82.2%). Gal-3 was significantly higher in PLWH than in HIV-uninfected participants (6.4 [IQR 4.0, 8.5] ng/mL and 4.5 [IQR 2.3, 6.5] ng/mL, respectively; p = 0.020) while a trend towards lower eGFR was found in PLWH compared to the HIV-uninfected cohort (86.8 [IQR 71.3, 91.8] and 89.0 [IQR 78.6, 97.4] mL/min/1.73 m2, respectively; p = 0.071). In univariable analysis, HIV status was marginally associated with decreased eGFR (β coefficient= −0.035, p = 0.051). In the final multivariable regression model adjusted for traditional risk factors of CKD, Gal-3 independently predicted a decrease in eGFR (unstandardized B= −0.008, p < 0.001) while HIV status did not demonstrate any significant association. Conclusion Gal-3 was higher in PLWH compared with HIV-uninfected participants. In multivariable adjusted analyses, Gal-3, but not HIV status, was associated with decreased eGFR. The role of Gal-3 as a biomarker of kidney function needs to be further elucidated.http://dx.doi.org/10.1080/25787489.2023.2261753hivkidney diseasekidney fibrosisgal-3egfr |
| spellingShingle | Diana L. Vares-Lum Louie Mar A. Gangcuangco Juwon Park Eduardo Manzano Michael Ortega Dominic C. Chow Cecilia Shikuma Plasma galectin-3 is associated with decreased glomerular filtration rate in chronic HIV HIV Research & Clinical Practice hiv kidney disease kidney fibrosis gal-3 egfr |
| title | Plasma galectin-3 is associated with decreased glomerular filtration rate in chronic HIV |
| title_full | Plasma galectin-3 is associated with decreased glomerular filtration rate in chronic HIV |
| title_fullStr | Plasma galectin-3 is associated with decreased glomerular filtration rate in chronic HIV |
| title_full_unstemmed | Plasma galectin-3 is associated with decreased glomerular filtration rate in chronic HIV |
| title_short | Plasma galectin-3 is associated with decreased glomerular filtration rate in chronic HIV |
| title_sort | plasma galectin 3 is associated with decreased glomerular filtration rate in chronic hiv |
| topic | hiv kidney disease kidney fibrosis gal-3 egfr |
| url | http://dx.doi.org/10.1080/25787489.2023.2261753 |
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