Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study
Background Diagnostic delay is one of the greatest challenges in spondyloarthritis (SpA). Better disease knowledge and more accessibility to new image technology could have a positive impact on time to diagnosis.Objectives The objectives are (1) to evaluate trends in time to diagnosis in SpA patient...
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2025-01-01
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| author | Robert Landewé Désirée van der Heijde Filip van den Bosch Maxime Dougados Anna Molto Stefan Siebert Juergen Braun Yuko Kaneko Adeline Ruyssen-Witrand Martin Soubrier Atsuo Taniguchi Masato Okada Alain Cantagrel Shigeto Kobayashi Jon Packham Philippe Goupille Rene-Marc Flipo Alain Saraux Philippe Gaudin Roberto Caporali Raj Sengupta James Cheng-Chung Wei Tetsuya Tomita Fernando Pimentel-Santos Alberto Ortiz Gaëlle Varkas Alejandro Martínez Shigeyoshi Tsuji Alejandro Alvarellos José Maldonado-Cocco Yoshinori Taniguchi Fadoua Allali Raquel Almodovar González Elena Alonso Blanco-Morales Maria Aparicio Espinar Pamir Atagunduz Pauline Bakker Leila Benbrahim Bahia Benchekroun Alberto Berman Pedro Carvalho Gustavo Casado Francisco Colombres Eugenio del Miguel Mendieta Vanesa Duarte Cristina Fernandez Carballido Manuel Fernandez-Prada Pilar Font Ugalde Dolors Grados Cánovas Jordi Gratacós Masmitjá Vittorio Grosso Naomi Ichikawa Hisashi Inoue Taku Kawasaki Manjari Lahiri Hernán Maldonado-Ficco Kazuo Matsui Ramón Mazzuchelli Esteban Corinne Micelli Chisun Min Mitsuhiro Morita Juan Mulero Mendoza Gisela Pendón Dora Pereira Hanan Rkain Oscar Rillo Carlos Rodriguez Lozano Adrián Salas Carlos Salinas-Ramos Amelia Santosa Caroline Spiegel Carmen Stolwijk Kurisu Tada Naoho Takizawa Chung Tei Chou Lay-Keng Teoh Wen-Chan Tsai Olga Tsyplenkova Kiana Vakil-Gilani Rafael Valle-Oñate Virginia Villaverde Ai Yap Pedro Zarco Montejo Juan C Barreira Juan D Diaz-Garcia Michel De Bandt Astrid van Tubergen Rodolfo Pérez-Alamino T Marhadour Christian Waimann Mari CruzFernandez Espartero Jose Raul NogueraPons José A PereiradaSilva |
| author_facet | Robert Landewé Désirée van der Heijde Filip van den Bosch Maxime Dougados Anna Molto Stefan Siebert Juergen Braun Yuko Kaneko Adeline Ruyssen-Witrand Martin Soubrier Atsuo Taniguchi Masato Okada Alain Cantagrel Shigeto Kobayashi Jon Packham Philippe Goupille Rene-Marc Flipo Alain Saraux Philippe Gaudin Roberto Caporali Raj Sengupta James Cheng-Chung Wei Tetsuya Tomita Fernando Pimentel-Santos Alberto Ortiz Gaëlle Varkas Alejandro Martínez Shigeyoshi Tsuji Alejandro Alvarellos José Maldonado-Cocco Yoshinori Taniguchi Fadoua Allali Raquel Almodovar González Elena Alonso Blanco-Morales Maria Aparicio Espinar Pamir Atagunduz Pauline Bakker Leila Benbrahim Bahia Benchekroun Alberto Berman Pedro Carvalho Gustavo Casado Francisco Colombres Eugenio del Miguel Mendieta Vanesa Duarte Cristina Fernandez Carballido Manuel Fernandez-Prada Pilar Font Ugalde Dolors Grados Cánovas Jordi Gratacós Masmitjá Vittorio Grosso Naomi Ichikawa Hisashi Inoue Taku Kawasaki Manjari Lahiri Hernán Maldonado-Ficco Kazuo Matsui Ramón Mazzuchelli Esteban Corinne Micelli Chisun Min Mitsuhiro Morita Juan Mulero Mendoza Gisela Pendón Dora Pereira Hanan Rkain Oscar Rillo Carlos Rodriguez Lozano Adrián Salas Carlos Salinas-Ramos Amelia Santosa Caroline Spiegel Carmen Stolwijk Kurisu Tada Naoho Takizawa Chung Tei Chou Lay-Keng Teoh Wen-Chan Tsai Olga Tsyplenkova Kiana Vakil-Gilani Rafael Valle-Oñate Virginia Villaverde Ai Yap Pedro Zarco Montejo Juan C Barreira Juan D Diaz-Garcia Michel De Bandt Astrid van Tubergen Rodolfo Pérez-Alamino T Marhadour Christian Waimann Mari CruzFernandez Espartero Jose Raul NogueraPons José A PereiradaSilva |
| collection | DOAJ |
| description | Background Diagnostic delay is one of the greatest challenges in spondyloarthritis (SpA). Better disease knowledge and more accessibility to new image technology could have a positive impact on time to diagnosis.Objectives The objectives are (1) to evaluate trends in time to diagnosis in SpA patients during the last decades and (2) to determine the association between clinical presentation and diagnostic delay.Methods Cross-sectional, retrospective international study, including 3984 patients with SpA diagnosis.Statistical analysis Delay in diagnosis was calculated and patients were stratified according to decade of disease onset and initial clinical presentation. Multivariate logistic model, using an early diagnosis (≤2 years) as dependent variable was used. P value<0.05 was considered statistically significant. A possible interaction between decade of disease onset and initial clinical presentation was performed.Results The overall median delay from disease onset to SpA diagnosis was 2.9 (p25−75=0.3–9.8) years. Diagnostic delay showed a progressive decrease during the last decades, patients with disease onset after 2010 showed a shorter delay in diagnosis than those with disease onset during 2000–2010 (m 2.00 vs 0.41 years, p<0.01). Age at disease onset (OR 1.02), axial symptom (OR 16.25), peripheral arthritis (OR 6.81), decade at disease onset (OR 3.80) and extra-musculoskeletal manifestation (OR 2.89) were associated with an early diagnosis, while female gender (OR 0.66) was inversely associated.Conclusions The proportion of patients with early SpA diagnosis improve from 15% before 1980 to 88% when first symptoms occurred after 2010. Type and number of initial clinical presentation were independent predictors of time to diagnosis. |
| format | Article |
| id | doaj-art-67bd95ecf22b4e4a9af1b8e3544046eb |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-67bd95ecf22b4e4a9af1b8e3544046eb2025-02-01T04:40:10ZengBMJ Publishing GroupRMD Open2056-59332025-01-0111110.1136/rmdopen-2024-004756Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study 0Robert Landewé1Désirée van der Heijde2Filip van den Bosch3Maxime Dougados4Anna Molto5Stefan SiebertJuergen BraunYuko KanekoAdeline Ruyssen-WitrandMartin SoubrierAtsuo TaniguchiMasato Okada6Alain CantagrelShigeto KobayashiJon PackhamPhilippe GoupilleRene-Marc FlipoAlain SarauxPhilippe GaudinRoberto CaporaliRaj Sengupta7James Cheng-Chung WeiTetsuya Tomita8Fernando Pimentel-SantosAlberto OrtizGaëlle VarkasAlejandro MartínezShigeyoshi TsujiAlejandro AlvarellosJosé Maldonado-Cocco9Yoshinori TaniguchiFadoua AllaliRaquel Almodovar GonzálezElena Alonso Blanco-MoralesMaria Aparicio EspinarPamir AtagunduzPauline BakkerLeila BenbrahimBahia BenchekrounAlberto BermanPedro CarvalhoGustavo CasadoFrancisco ColombresEugenio del Miguel MendietaVanesa DuarteCristina Fernandez CarballidoManuel Fernandez-PradaPilar Font UgaldeDolors Grados CánovasJordi Gratacós MasmitjáVittorio GrossoNaomi IchikawaHisashi InoueTaku KawasakiManjari LahiriHernán Maldonado-Ficco10Kazuo MatsuiRamón Mazzuchelli EstebanCorinne MicelliChisun MinMitsuhiro MoritaJuan Mulero MendozaGisela PendónDora PereiraHanan RkainOscar RilloCarlos Rodriguez LozanoAdrián SalasCarlos Salinas-RamosAmelia SantosaCaroline SpiegelCarmen StolwijkKurisu TadaNaoho TakizawaChung Tei ChouLay-Keng TeohWen-Chan TsaiOlga TsyplenkovaKiana Vakil-GilaniRafael Valle-OñateVirginia VillaverdeAi YapPedro Zarco MontejoJuan C BarreiraJuan D Diaz-GarciaMichel De BandtAstrid van TubergenRodolfo Pérez-Alamino11T MarhadourChristian Waimann12Mari CruzFernandez EsparteroJose Raul NogueraPonsJosé A PereiradaSilva11 Kenya National Bureau of Statistics, Nairobi, Nairobi, KenyaClinical Immunology & Rheumatology, Amsterdam University Medical Centres, Amsterdam, The NetherlandsRheumatology, Leiden University Medical Center, Leiden, Zuid-Holland, NetherlandsRheumatology, University Hospital Ghent, Ghent, BelgiumHopital Cochin, Rheumatology, Université Paris Descartes Faculté de Médecine, Paris, FranceRheumatology, Hospital Cochin, Paris, France2 Immuno-Rheumatology Center, St. Luke`s international Hospital, Tokyo, Japan26 Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, UKGraduate School of Health Science, Morinomiya University of Medical Sciences, Osaka City, Osaka, JapanBuenos Aires University School of Medicine, Buenos Aires, ArgentinaRheumatology, Hospital San Antonio de Padua, Rio Cuarto, ArgentinaHospital Avellaneda, Tucuman, ArgentinaFacultad de Ciencias de la Salud de la Universidad Nacional del Centro de la Provincia de Buenos Aires, Olavarría, ArgentinaBackground Diagnostic delay is one of the greatest challenges in spondyloarthritis (SpA). Better disease knowledge and more accessibility to new image technology could have a positive impact on time to diagnosis.Objectives The objectives are (1) to evaluate trends in time to diagnosis in SpA patients during the last decades and (2) to determine the association between clinical presentation and diagnostic delay.Methods Cross-sectional, retrospective international study, including 3984 patients with SpA diagnosis.Statistical analysis Delay in diagnosis was calculated and patients were stratified according to decade of disease onset and initial clinical presentation. Multivariate logistic model, using an early diagnosis (≤2 years) as dependent variable was used. P value<0.05 was considered statistically significant. A possible interaction between decade of disease onset and initial clinical presentation was performed.Results The overall median delay from disease onset to SpA diagnosis was 2.9 (p25−75=0.3–9.8) years. Diagnostic delay showed a progressive decrease during the last decades, patients with disease onset after 2010 showed a shorter delay in diagnosis than those with disease onset during 2000–2010 (m 2.00 vs 0.41 years, p<0.01). Age at disease onset (OR 1.02), axial symptom (OR 16.25), peripheral arthritis (OR 6.81), decade at disease onset (OR 3.80) and extra-musculoskeletal manifestation (OR 2.89) were associated with an early diagnosis, while female gender (OR 0.66) was inversely associated.Conclusions The proportion of patients with early SpA diagnosis improve from 15% before 1980 to 88% when first symptoms occurred after 2010. Type and number of initial clinical presentation were independent predictors of time to diagnosis.https://rmdopen.bmj.com/content/11/1/e004756.full |
| spellingShingle | Robert Landewé Désirée van der Heijde Filip van den Bosch Maxime Dougados Anna Molto Stefan Siebert Juergen Braun Yuko Kaneko Adeline Ruyssen-Witrand Martin Soubrier Atsuo Taniguchi Masato Okada Alain Cantagrel Shigeto Kobayashi Jon Packham Philippe Goupille Rene-Marc Flipo Alain Saraux Philippe Gaudin Roberto Caporali Raj Sengupta James Cheng-Chung Wei Tetsuya Tomita Fernando Pimentel-Santos Alberto Ortiz Gaëlle Varkas Alejandro Martínez Shigeyoshi Tsuji Alejandro Alvarellos José Maldonado-Cocco Yoshinori Taniguchi Fadoua Allali Raquel Almodovar González Elena Alonso Blanco-Morales Maria Aparicio Espinar Pamir Atagunduz Pauline Bakker Leila Benbrahim Bahia Benchekroun Alberto Berman Pedro Carvalho Gustavo Casado Francisco Colombres Eugenio del Miguel Mendieta Vanesa Duarte Cristina Fernandez Carballido Manuel Fernandez-Prada Pilar Font Ugalde Dolors Grados Cánovas Jordi Gratacós Masmitjá Vittorio Grosso Naomi Ichikawa Hisashi Inoue Taku Kawasaki Manjari Lahiri Hernán Maldonado-Ficco Kazuo Matsui Ramón Mazzuchelli Esteban Corinne Micelli Chisun Min Mitsuhiro Morita Juan Mulero Mendoza Gisela Pendón Dora Pereira Hanan Rkain Oscar Rillo Carlos Rodriguez Lozano Adrián Salas Carlos Salinas-Ramos Amelia Santosa Caroline Spiegel Carmen Stolwijk Kurisu Tada Naoho Takizawa Chung Tei Chou Lay-Keng Teoh Wen-Chan Tsai Olga Tsyplenkova Kiana Vakil-Gilani Rafael Valle-Oñate Virginia Villaverde Ai Yap Pedro Zarco Montejo Juan C Barreira Juan D Diaz-Garcia Michel De Bandt Astrid van Tubergen Rodolfo Pérez-Alamino T Marhadour Christian Waimann Mari CruzFernandez Espartero Jose Raul NogueraPons José A PereiradaSilva Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study RMD Open |
| title | Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study |
| title_full | Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study |
| title_fullStr | Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study |
| title_full_unstemmed | Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study |
| title_short | Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study |
| title_sort | trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation data from asas comospa study |
| url | https://rmdopen.bmj.com/content/11/1/e004756.full |
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