Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System
This work evaluated the antioxidant properties and in vivo antinociceptive and anti-inflammatory effects of extracts obtained from fruit peels of Myrciaria floribunda (H. West ex Willd.) O. Berg (Myrtaceae). This plant is popularly known in Brazil as Cambuí or camboim. Different extracts were submit...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Pharmacological and Pharmaceutical Sciences |
| Online Access: | http://dx.doi.org/10.1155/2020/1258707 |
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| author | Izabelly Bianca da Silva Santos Bruno Santos dos Santos João Ricardhis Saturnino de Oliveira Wêndeo Kennedy Costa Adrielle Zagmignan Luís Cláudio Nascimento da Silva Magda Rhayanny Assunção Ferreira Vilmar Luiz Lermen Maria Silvanete Benedito de Sousa Lermen Alexandre Gomes da Silva Rafael Matos Ximenes Luiz Alberto Lira Soares Patrícia Maria Guedes Paiva Vera Lúcia de Menezes Lima Maria Tereza dos Santos Correia Márcia Vanusa da Silva |
| author_facet | Izabelly Bianca da Silva Santos Bruno Santos dos Santos João Ricardhis Saturnino de Oliveira Wêndeo Kennedy Costa Adrielle Zagmignan Luís Cláudio Nascimento da Silva Magda Rhayanny Assunção Ferreira Vilmar Luiz Lermen Maria Silvanete Benedito de Sousa Lermen Alexandre Gomes da Silva Rafael Matos Ximenes Luiz Alberto Lira Soares Patrícia Maria Guedes Paiva Vera Lúcia de Menezes Lima Maria Tereza dos Santos Correia Márcia Vanusa da Silva |
| author_sort | Izabelly Bianca da Silva Santos |
| collection | DOAJ |
| description | This work evaluated the antioxidant properties and in vivo antinociceptive and anti-inflammatory effects of extracts obtained from fruit peels of Myrciaria floribunda (H. West ex Willd.) O. Berg (Myrtaceae). This plant is popularly known in Brazil as Cambuí or camboim. Different extracts were submitted to comparative analysis to determine the content of selected phytochemical classes (levels of total phenols, flavonoids, and monomeric anthocyanins) and the in vitro antioxidant potentials. The extract with higher potential was selected for in vivo evaluation of its antinociceptive and anti-inflammatory action. Finally, the chemical characterization of this extract was performed by high-performance liquid chromatography (HPLC). MfAE (extract obtained using acetone as solvent) showed the higher levels of phenols (296 mg GAE/g) and anthocyanins contents (35.65 mg Cy-3-glcE/g) that were associated with higher antioxidant activity. MfAE also exhibited in vivo anti-inflammatory and analgesic propertiers. This fraction inhibited the inflammatory and neurogenic phases of pain, and this effect was reversed by naloxone (suggesting the involvement of opioidergic system). MfAE reduced the abdominal contortions induced by acetic acid. The HPLC analysis revealed the presence of gallic acid (and its derivatives) and ellagic acid. Taken together, these data support the use of M. floribunda fruit peels for development of functional foods and nutraceutics. |
| format | Article |
| id | doaj-art-67b0468c79254d1cad92259c8a4259c2 |
| institution | Kabale University |
| issn | 2633-4690 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological and Pharmaceutical Sciences |
| spelling | doaj-art-67b0468c79254d1cad92259c8a4259c22025-02-03T01:05:09ZengWileyAdvances in Pharmacological and Pharmaceutical Sciences2633-46902020-01-01202010.1155/2020/12587071258707Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic SystemIzabelly Bianca da Silva Santos0Bruno Santos dos Santos1João Ricardhis Saturnino de Oliveira2Wêndeo Kennedy Costa3Adrielle Zagmignan4Luís Cláudio Nascimento da Silva5Magda Rhayanny Assunção Ferreira6Vilmar Luiz Lermen7Maria Silvanete Benedito de Sousa Lermen8Alexandre Gomes da Silva9Rafael Matos Ximenes10Luiz Alberto Lira Soares11Patrícia Maria Guedes Paiva12Vera Lúcia de Menezes Lima13Maria Tereza dos Santos Correia14Márcia Vanusa da Silva15Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilPrograma de Pós-Graduação, Universidade Ceuma, São Luís, MA 65075-120, BrazilPrograma de Pós-Graduação, Universidade Ceuma, São Luís, MA 65075-120, BrazilDepartamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilComunidade Serra dos Paus Dóias Chapada do Araripe, Exu, PE 56230-000, BrazilComunidade Serra dos Paus Dóias Chapada do Araripe, Exu, PE 56230-000, BrazilDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilDepartamento de Antibióticos, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilDepartamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE 50670-901, BrazilThis work evaluated the antioxidant properties and in vivo antinociceptive and anti-inflammatory effects of extracts obtained from fruit peels of Myrciaria floribunda (H. West ex Willd.) O. Berg (Myrtaceae). This plant is popularly known in Brazil as Cambuí or camboim. Different extracts were submitted to comparative analysis to determine the content of selected phytochemical classes (levels of total phenols, flavonoids, and monomeric anthocyanins) and the in vitro antioxidant potentials. The extract with higher potential was selected for in vivo evaluation of its antinociceptive and anti-inflammatory action. Finally, the chemical characterization of this extract was performed by high-performance liquid chromatography (HPLC). MfAE (extract obtained using acetone as solvent) showed the higher levels of phenols (296 mg GAE/g) and anthocyanins contents (35.65 mg Cy-3-glcE/g) that were associated with higher antioxidant activity. MfAE also exhibited in vivo anti-inflammatory and analgesic propertiers. This fraction inhibited the inflammatory and neurogenic phases of pain, and this effect was reversed by naloxone (suggesting the involvement of opioidergic system). MfAE reduced the abdominal contortions induced by acetic acid. The HPLC analysis revealed the presence of gallic acid (and its derivatives) and ellagic acid. Taken together, these data support the use of M. floribunda fruit peels for development of functional foods and nutraceutics.http://dx.doi.org/10.1155/2020/1258707 |
| spellingShingle | Izabelly Bianca da Silva Santos Bruno Santos dos Santos João Ricardhis Saturnino de Oliveira Wêndeo Kennedy Costa Adrielle Zagmignan Luís Cláudio Nascimento da Silva Magda Rhayanny Assunção Ferreira Vilmar Luiz Lermen Maria Silvanete Benedito de Sousa Lermen Alexandre Gomes da Silva Rafael Matos Ximenes Luiz Alberto Lira Soares Patrícia Maria Guedes Paiva Vera Lúcia de Menezes Lima Maria Tereza dos Santos Correia Márcia Vanusa da Silva Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System Advances in Pharmacological and Pharmaceutical Sciences |
| title | Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System |
| title_full | Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System |
| title_fullStr | Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System |
| title_full_unstemmed | Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System |
| title_short | Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System |
| title_sort | antioxidant action and in vivo anti inflammatory and antinociceptive activities of myrciaria floribunda fruit peels possible involvement of opioidergic system |
| url | http://dx.doi.org/10.1155/2020/1258707 |
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