Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint Defects
Osteoarthritis is a common condition that causes joint pain and stiffness that affects both humans and dogs. In Australia, allogeneic canine adipose-derived mesenchymal stem cells for therapy have been commercially available since 2010. In this report, we describe the outcome of the treatment of two...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/7309201 |
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| _version_ | 1832568364723077120 |
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| author | Kiran Shah Tara Drury Ivelise Roic Peter Hansen Mark Malin Richard Boyd Huseyin Sumer Ray Ferguson |
| author_facet | Kiran Shah Tara Drury Ivelise Roic Peter Hansen Mark Malin Richard Boyd Huseyin Sumer Ray Ferguson |
| author_sort | Kiran Shah |
| collection | DOAJ |
| description | Osteoarthritis is a common condition that causes joint pain and stiffness that affects both humans and dogs. In Australia, allogeneic canine adipose-derived mesenchymal stem cells for therapy have been commercially available since 2010. In this report, we describe the outcome of the treatment of two hundred and three dogs diagnosed with degenerative arthritis with severe chronic pain in joints causing lameness at walk, reduced mobility, and functional disability. Posttreatment assessment data after 10 weeks revealed significant improvement (p<0.007) of the symptoms: pain reduction, improvement of mobility, and increased daily activity as measured as quality of life score. Ninety percent of young dogs (<9 years) showed excellent improvement in pain and mobility and were able to run and resume normal activity. Sixty percent of older dogs showed good improvement. However, 12% of dogs did not exhibit any change in symptoms; one dog showed worsening of the symptoms. This report provides the support for the safety and efficacies of allogeneic adipose-derived mesenchymal stem cells in a regenerative therapeutic veterinary model. |
| format | Article |
| id | doaj-art-67acb1804afe40c694008cb1554d2a73 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-67acb1804afe40c694008cb1554d2a732025-02-03T00:59:12ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/73092017309201Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint DefectsKiran Shah0Tara Drury1Ivelise Roic2Peter Hansen3Mark Malin4Richard Boyd5Huseyin Sumer6Ray Ferguson7Australian Veterinary Stem Cell P/L, Melbourne, AustraliaAustralian Veterinary Stem Cell P/L, Melbourne, AustraliaAustralian Veterinary Stem Cell P/L, Melbourne, AustraliaAustralian Veterinary Stem Cell P/L, Melbourne, AustraliaHudson Institute, Clayton, AustraliaHudson Institute, Clayton, AustraliaSwinburne University of Technology, Hawthorn, AustraliaMonash Vet Clinic, Clayton, AustraliaOsteoarthritis is a common condition that causes joint pain and stiffness that affects both humans and dogs. In Australia, allogeneic canine adipose-derived mesenchymal stem cells for therapy have been commercially available since 2010. In this report, we describe the outcome of the treatment of two hundred and three dogs diagnosed with degenerative arthritis with severe chronic pain in joints causing lameness at walk, reduced mobility, and functional disability. Posttreatment assessment data after 10 weeks revealed significant improvement (p<0.007) of the symptoms: pain reduction, improvement of mobility, and increased daily activity as measured as quality of life score. Ninety percent of young dogs (<9 years) showed excellent improvement in pain and mobility and were able to run and resume normal activity. Sixty percent of older dogs showed good improvement. However, 12% of dogs did not exhibit any change in symptoms; one dog showed worsening of the symptoms. This report provides the support for the safety and efficacies of allogeneic adipose-derived mesenchymal stem cells in a regenerative therapeutic veterinary model.http://dx.doi.org/10.1155/2018/7309201 |
| spellingShingle | Kiran Shah Tara Drury Ivelise Roic Peter Hansen Mark Malin Richard Boyd Huseyin Sumer Ray Ferguson Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint Defects Stem Cells International |
| title | Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint Defects |
| title_full | Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint Defects |
| title_fullStr | Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint Defects |
| title_full_unstemmed | Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint Defects |
| title_short | Outcome of Allogeneic Adult Stem Cell Therapy in Dogs Suffering from Osteoarthritis and Other Joint Defects |
| title_sort | outcome of allogeneic adult stem cell therapy in dogs suffering from osteoarthritis and other joint defects |
| url | http://dx.doi.org/10.1155/2018/7309201 |
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