Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity
Asthma is a heterogeneous disease characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and intensity, together with variable expiratory airflow limitation. A personal hi...
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PAGEPress Publications
2025-01-01
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| Series: | Monaldi Archives for Chest Disease |
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| Online Access: | https://www.monaldi-archives.org/macd/article/view/3095 |
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| author | Nidhi Girdhar Karan Sharma Satyajit Deshpande Siddharth Sharma Vishal Chopra Anil Sontakke |
| author_facet | Nidhi Girdhar Karan Sharma Satyajit Deshpande Siddharth Sharma Vishal Chopra Anil Sontakke |
| author_sort | Nidhi Girdhar |
| collection | DOAJ |
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Asthma is a heterogeneous disease characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and intensity, together with variable expiratory airflow limitation. A personal history or a family history of allergy is the factor most strongly associated with the development of asthma. Our primary aim was to investigate interleukin-4 receptor α (IL-4Rα) polymorphism to determine whether the presence of the R576 IL-4Rα allele was associated with asthma and whether the presence of the R576 allele influenced the severity of asthma in affected individuals. The data obtained indicated asthmatic patients were characterized by a higher prevalence of positive family history of asthma (p<0.001) as compared to controls. It was found that the patients homozygous for mutant alleles had a 1.39-fold increased risk of asthma compared with individuals not homozygous for R576. Also, we found that females had higher odds (1.61-fold) of significant association with asthma (p=0.09; odds ratio=1.58). While this report clearly necessitates a more detailed study, it is plausible that IL-4 mutation has a significant role in the development of asthma and, thus, can play an important role in developing targeted therapy.
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| format | Article |
| id | doaj-art-67a8703990f843fe9cccb28c43d7148d |
| institution | Kabale University |
| issn | 1122-0643 2532-5264 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | PAGEPress Publications |
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| series | Monaldi Archives for Chest Disease |
| spelling | doaj-art-67a8703990f843fe9cccb28c43d7148d2025-01-28T01:39:42ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642025-01-0110.4081/monaldi.2025.3095Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severityNidhi Girdhar0https://orcid.org/0000-0003-4690-4796Karan Sharma1https://orcid.org/0000-0003-1872-6136Satyajit Deshpande2https://orcid.org/0009-0007-3771-8023Siddharth Sharma3https://orcid.org/0000-0001-9414-3771Vishal Chopra4Anil Sontakke5https://orcid.org/0000-0001-7369-3045Department of Respiratory Medicine, N.K.P. Salve Institute of Medical Sciences and Research Center, Lata Mangeshkar Hospital, Nagpur, MaharashtraDepartment of Respiratory Medicine, Government Medical College, Sri Ganganagar, RajasthanDepartment of Orthopedics, N.K.P. Salve Institute of Medical Sciences and Research Center, Lata Mangeshkar Hospital, Nagpur, MaharashtraDepartment of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, PunjabDepartment of Respiratory Medicine, Government Medical College, Patiala, PunjabDepartment of Respiratory Medicine, N.K.P. Salve Institute of Medical Sciences and Research Center, Lata Mangeshkar Hospital, Nagpur, Maharashtra Asthma is a heterogeneous disease characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and intensity, together with variable expiratory airflow limitation. A personal history or a family history of allergy is the factor most strongly associated with the development of asthma. Our primary aim was to investigate interleukin-4 receptor α (IL-4Rα) polymorphism to determine whether the presence of the R576 IL-4Rα allele was associated with asthma and whether the presence of the R576 allele influenced the severity of asthma in affected individuals. The data obtained indicated asthmatic patients were characterized by a higher prevalence of positive family history of asthma (p<0.001) as compared to controls. It was found that the patients homozygous for mutant alleles had a 1.39-fold increased risk of asthma compared with individuals not homozygous for R576. Also, we found that females had higher odds (1.61-fold) of significant association with asthma (p=0.09; odds ratio=1.58). While this report clearly necessitates a more detailed study, it is plausible that IL-4 mutation has a significant role in the development of asthma and, thus, can play an important role in developing targeted therapy. https://www.monaldi-archives.org/macd/article/view/3095Bronchial asthmageneticsIL-4IL-4 receptorTH2 cytokine |
| spellingShingle | Nidhi Girdhar Karan Sharma Satyajit Deshpande Siddharth Sharma Vishal Chopra Anil Sontakke Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity Monaldi Archives for Chest Disease Bronchial asthma genetics IL-4 IL-4 receptor TH2 cytokine |
| title | Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity |
| title_full | Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity |
| title_fullStr | Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity |
| title_full_unstemmed | Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity |
| title_short | Role of interleukin-4 receptor α polymorphism in patients with asthma and its correlation with asthma severity |
| title_sort | role of interleukin 4 receptor α polymorphism in patients with asthma and its correlation with asthma severity |
| topic | Bronchial asthma genetics IL-4 IL-4 receptor TH2 cytokine |
| url | https://www.monaldi-archives.org/macd/article/view/3095 |
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