Predicted indirectly recognizable HLA epitopes scores and clinical outcomes after haploidentical stem cell transplantation in pediatric patients with relapsed neuroblastoma

Predicted indirectly recognizable HLA epitopes scores and clinical outcomes after haploidentical stem cell transplantation in pediatric patients with relapsed neuroblastoma

IntroductionThe Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) model is a recently developed algorithm that predicts indirect T-cell recognition by calculating the number of such epitopes in donor-recipient pairs.MethodsIn this study, the clinical significance of PIRCHE was evaluated in ped...

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Main Authors: Eun Seop Seo, In Hwa Jeong, Hee Young Ju, Ju Kyung Hyun, Ji Won Lee, Keon Hee Yoo, Won Young Heo, Ki Woong Sung, Hee Won Cho, Eun-Suk Kang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
neuroblastoma
PIRCHE
haploidentical hematopoietic stem cell transplantation
relapse/refractory
HLA mismatch
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1517387/full
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