Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trial
Abstract To report the results of a single-arm, prospective partial breast irradiation (PBI) trial from China mainland using a dose of 40.05 Gy in 15 fractions delivered with intensity-modulated radiation therapy (IMRT) technique for patients with early stage breast cancer. Patients aged ≥ 50 years...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-88600-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571727604875264 |
|---|---|
| author | Xiaomeng Zhang Xiaofang Wang Zhuohua Xu Yajuan Chu Xingxing Chen Li Zhang Jin Meng Wei Shi Zhaozhi Yang Xin Mei Xiaoli Yu Zhen Zhang Xiaomao Guo Miao Mo Guangyu Liu Jiong Wu Zhimin Shao Jinli Ma |
| author_facet | Xiaomeng Zhang Xiaofang Wang Zhuohua Xu Yajuan Chu Xingxing Chen Li Zhang Jin Meng Wei Shi Zhaozhi Yang Xin Mei Xiaoli Yu Zhen Zhang Xiaomao Guo Miao Mo Guangyu Liu Jiong Wu Zhimin Shao Jinli Ma |
| author_sort | Xiaomeng Zhang |
| collection | DOAJ |
| description | Abstract To report the results of a single-arm, prospective partial breast irradiation (PBI) trial from China mainland using a dose of 40.05 Gy in 15 fractions delivered with intensity-modulated radiation therapy (IMRT) technique for patients with early stage breast cancer. Patients aged ≥ 50 years who underwent breast-conserving surgery for unifocal non-lobular invasive breast cancer, with pathological T1 disease, clear margins, negative axillary nodes, and positive hormonal receptors, were recruited. The primary endpoint was 3-year cosmetic deterioration, and secondary endpoints included adverse events, ipsilateral breast tumor recurrence (IBTR), regional recurrence, and survivals. This trial is registered with ClinicalTrials.gov (registration No. NCT03411174). From Jan of 2015 to July of 2018, 208 out of 222 patients recruited were evaluable and included in final analysis. The median follow-up was 66.3 (range: 42.0-105.4) months. The 3-year overall cosmetic deterioration rate was 3.5%. The rates of grade 2 radiation dermatitis and breast induration was 5.8% and 1.5%, respectively. No one experienced ≥ grade 2 breast pain, edema, or telangiectasia. The 5-year cumulative incidence of IBTR and RR was 0.5%. No one developed DM. The 5-year DFS was 99.0%. Four patients died from non-breast cancer causes, and the 5- year OS was 97.9%. In conclusion, we observed lower rates of cosmetic deterioration, IBTR, and ≥ grade 2 acute/late normal tissue effects following PBI with a moderately hypofractionated regimen delivered with IMRT technique. Therefore, this regimen represents an attractive option when an external beam PBI approach is chosen to treat a patient with low-risk early breast cancer. |
| format | Article |
| id | doaj-art-679a86759f3749ad865aeea9335f8345 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-679a86759f3749ad865aeea9335f83452025-02-02T12:23:20ZengNature PortfolioScientific Reports2045-23222025-01-011511810.1038/s41598-025-88600-5Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trialXiaomeng Zhang0Xiaofang Wang1Zhuohua Xu2Yajuan Chu3Xingxing Chen4Li Zhang5Jin Meng6Wei Shi7Zhaozhi Yang8Xin Mei9Xiaoli Yu10Zhen Zhang11Xiaomao Guo12Miao Mo13Guangyu Liu14Jiong Wu15Zhimin Shao16Jinli Ma17Department of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Oncology, The Fourth Affiliated Hospital of Guangxi Medical UniversityDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Radiation Oncology, Fudan University Shanghai Cancer CenterAbstract To report the results of a single-arm, prospective partial breast irradiation (PBI) trial from China mainland using a dose of 40.05 Gy in 15 fractions delivered with intensity-modulated radiation therapy (IMRT) technique for patients with early stage breast cancer. Patients aged ≥ 50 years who underwent breast-conserving surgery for unifocal non-lobular invasive breast cancer, with pathological T1 disease, clear margins, negative axillary nodes, and positive hormonal receptors, were recruited. The primary endpoint was 3-year cosmetic deterioration, and secondary endpoints included adverse events, ipsilateral breast tumor recurrence (IBTR), regional recurrence, and survivals. This trial is registered with ClinicalTrials.gov (registration No. NCT03411174). From Jan of 2015 to July of 2018, 208 out of 222 patients recruited were evaluable and included in final analysis. The median follow-up was 66.3 (range: 42.0-105.4) months. The 3-year overall cosmetic deterioration rate was 3.5%. The rates of grade 2 radiation dermatitis and breast induration was 5.8% and 1.5%, respectively. No one experienced ≥ grade 2 breast pain, edema, or telangiectasia. The 5-year cumulative incidence of IBTR and RR was 0.5%. No one developed DM. The 5-year DFS was 99.0%. Four patients died from non-breast cancer causes, and the 5- year OS was 97.9%. In conclusion, we observed lower rates of cosmetic deterioration, IBTR, and ≥ grade 2 acute/late normal tissue effects following PBI with a moderately hypofractionated regimen delivered with IMRT technique. Therefore, this regimen represents an attractive option when an external beam PBI approach is chosen to treat a patient with low-risk early breast cancer.https://doi.org/10.1038/s41598-025-88600-5Breast CancerHypofractionated partial breast irradiationIntensity-modulatedCosmetic outcome |
| spellingShingle | Xiaomeng Zhang Xiaofang Wang Zhuohua Xu Yajuan Chu Xingxing Chen Li Zhang Jin Meng Wei Shi Zhaozhi Yang Xin Mei Xiaoli Yu Zhen Zhang Xiaomao Guo Miao Mo Guangyu Liu Jiong Wu Zhimin Shao Jinli Ma Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trial Scientific Reports Breast Cancer Hypofractionated partial breast irradiation Intensity-modulated Cosmetic outcome |
| title | Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trial |
| title_full | Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trial |
| title_fullStr | Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trial |
| title_full_unstemmed | Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trial |
| title_short | Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trial |
| title_sort | hypofractionated partial breast irradiation after breast conserving surgery for patients with early stage breast cancer in china mainland a single arm prospective trial |
| topic | Breast Cancer Hypofractionated partial breast irradiation Intensity-modulated Cosmetic outcome |
| url | https://doi.org/10.1038/s41598-025-88600-5 |
| work_keys_str_mv | AT xiaomengzhang hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT xiaofangwang hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT zhuohuaxu hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT yajuanchu hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT xingxingchen hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT lizhang hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT jinmeng hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT weishi hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT zhaozhiyang hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT xinmei hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT xiaoliyu hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT zhenzhang hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT xiaomaoguo hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT miaomo hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT guangyuliu hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT jiongwu hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT zhiminshao hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial AT jinlima hypofractionatedpartialbreastirradiationafterbreastconservingsurgeryforpatientswithearlystagebreastcancerinchinamainlandasinglearmprospectivetrial |