Equine Infectious Anemia Virus Cellular Partners Along the Viral Cycle
Equine infectious anemia virus (EIAV) is the simplest described <i>lentivirus</i> within the <i>Retroviridae</i> family, related to the human immunodeficiency viruses (HIV-1 and HIV-2). There is an important interplay between host cells and viruses. Viruses need to hijack cel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/1/5 |
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| author | Cécile Schimmich Astrid Vabret Stéphan Zientara José Carlos Valle-Casuso |
| author_facet | Cécile Schimmich Astrid Vabret Stéphan Zientara José Carlos Valle-Casuso |
| author_sort | Cécile Schimmich |
| collection | DOAJ |
| description | Equine infectious anemia virus (EIAV) is the simplest described <i>lentivirus</i> within the <i>Retroviridae</i> family, related to the human immunodeficiency viruses (HIV-1 and HIV-2). There is an important interplay between host cells and viruses. Viruses need to hijack cellular proteins for their viral cycle completion and some cellular proteins are antiviral agents interfering with viral replication. HIV cellular partners have been extensively studied and described, with a special attention to host proteins able to inhibit specific steps of the viral cycle, called restriction factors. Viruses develop countermeasures against these restriction factors. Here, we aim to describe host cellular protein partners of EIAV viral replication, being proviral or antiviral. A comprehensive vision of the interactions between the virus and specific host’s proteins can help with the discovery of new targets for the design of therapeutics. Studies performed on HIV-1 can provide insights into the functioning of EIAV, as well as differences, as both types of virus research can benefit from each other. |
| format | Article |
| id | doaj-art-678660aec54e41d4a637183ff19720b4 |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-678660aec54e41d4a637183ff19720b42025-01-24T13:52:13ZengMDPI AGViruses1999-49152024-12-01171510.3390/v17010005Equine Infectious Anemia Virus Cellular Partners Along the Viral CycleCécile Schimmich0Astrid Vabret1Stéphan Zientara2José Carlos Valle-Casuso3ANSES Animal Health Laboratory, PhEED Unit, 14430 Goustranville, FranceDepartment of Virology, University of Caen Normandy, Dynamicure INSERM UMR 1311, Centre Hospitalo Universitaire (CHU) Caen, 14000 Caen, FranceUMR VIROLOGIE, INRAE, École Nationale Vétérinaire d’Alfort, ANSES Laboratoire de Santé Animale, Université Paris-Est, 94700 Maisons-Alfort, FranceANSES Animal Health Laboratory, PhEED Unit, 14430 Goustranville, FranceEquine infectious anemia virus (EIAV) is the simplest described <i>lentivirus</i> within the <i>Retroviridae</i> family, related to the human immunodeficiency viruses (HIV-1 and HIV-2). There is an important interplay between host cells and viruses. Viruses need to hijack cellular proteins for their viral cycle completion and some cellular proteins are antiviral agents interfering with viral replication. HIV cellular partners have been extensively studied and described, with a special attention to host proteins able to inhibit specific steps of the viral cycle, called restriction factors. Viruses develop countermeasures against these restriction factors. Here, we aim to describe host cellular protein partners of EIAV viral replication, being proviral or antiviral. A comprehensive vision of the interactions between the virus and specific host’s proteins can help with the discovery of new targets for the design of therapeutics. Studies performed on HIV-1 can provide insights into the functioning of EIAV, as well as differences, as both types of virus research can benefit from each other.https://www.mdpi.com/1999-4915/17/1/5EIAVHIV-1host–pathogen interactionsrestriction factors<i>lentivirus</i>viral cycle |
| spellingShingle | Cécile Schimmich Astrid Vabret Stéphan Zientara José Carlos Valle-Casuso Equine Infectious Anemia Virus Cellular Partners Along the Viral Cycle Viruses EIAV HIV-1 host–pathogen interactions restriction factors <i>lentivirus</i> viral cycle |
| title | Equine Infectious Anemia Virus Cellular Partners Along the Viral Cycle |
| title_full | Equine Infectious Anemia Virus Cellular Partners Along the Viral Cycle |
| title_fullStr | Equine Infectious Anemia Virus Cellular Partners Along the Viral Cycle |
| title_full_unstemmed | Equine Infectious Anemia Virus Cellular Partners Along the Viral Cycle |
| title_short | Equine Infectious Anemia Virus Cellular Partners Along the Viral Cycle |
| title_sort | equine infectious anemia virus cellular partners along the viral cycle |
| topic | EIAV HIV-1 host–pathogen interactions restriction factors <i>lentivirus</i> viral cycle |
| url | https://www.mdpi.com/1999-4915/17/1/5 |
| work_keys_str_mv | AT cecileschimmich equineinfectiousanemiaviruscellularpartnersalongtheviralcycle AT astridvabret equineinfectiousanemiaviruscellularpartnersalongtheviralcycle AT stephanzientara equineinfectiousanemiaviruscellularpartnersalongtheviralcycle AT josecarlosvallecasuso equineinfectiousanemiaviruscellularpartnersalongtheviralcycle |