Phylogeny-Directed Search for Murine Leukemia Virus-Like Retroviruses in Vertebrate Genomes and in Patients Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate Cancer
Gammaretrovirus-like sequences occur in most vertebrate genomes. Murine Leukemia Virus (MLV) like retroviruses (MLLVs) are a subset, which may be pathogenic and spread cross-species. Retroviruses highly similar to MLLVs (xenotropic murine retrovirus related virus (XMRV) and Human Mouse retrovirus-li...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2011/341294 |
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| author | Jonas Blomberg Ali Sheikholvaezin Amal Elfaitouri Fredrik Blomberg Anna Sjösten Johan Mattson Ulfstedt Rüdiger Pipkorn Clas Källander Christina Öhrmalm Göran Sperber |
| author_facet | Jonas Blomberg Ali Sheikholvaezin Amal Elfaitouri Fredrik Blomberg Anna Sjösten Johan Mattson Ulfstedt Rüdiger Pipkorn Clas Källander Christina Öhrmalm Göran Sperber |
| author_sort | Jonas Blomberg |
| collection | DOAJ |
| description | Gammaretrovirus-like sequences occur in most vertebrate genomes. Murine Leukemia Virus (MLV) like retroviruses (MLLVs) are a subset, which may be pathogenic and spread cross-species. Retroviruses highly similar to MLLVs (xenotropic murine retrovirus related virus (XMRV) and Human Mouse retrovirus-like RetroViruses (HMRVs)) reported from patients suffering from prostate cancer (PC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) raise the possibility that also humans have been infected. Structurally intact, potentially infectious MLLVs occur in the genomes of some mammals, especially mouse. Mouse MLLVs contain three major groups. One, MERV G3, contained MLVs and XMRV/HMRV. Its presence in mouse DNA, and the abundance of xenotropic MLVs in biologicals, is a source of false positivity. Theoretically, XMRV/HMRV could be one of several MLLV transspecies infections. MLLV pathobiology and diversity indicate optimal strategies for investigating XMRV/HMRV in humans and raise ethical concerns. The alternatives that XMRV/HMRV may give a hard-to-detect “stealth” infection, or that XMRV/HMRV never reached humans, have to be considered. |
| format | Article |
| id | doaj-art-675b88ae8ed64472aa9358f9729036b7 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-675b88ae8ed64472aa9358f9729036b72025-02-03T01:00:35ZengWileyAdvances in Virology1687-86391687-86472011-01-01201110.1155/2011/341294341294Phylogeny-Directed Search for Murine Leukemia Virus-Like Retroviruses in Vertebrate Genomes and in Patients Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate CancerJonas Blomberg0Ali Sheikholvaezin1Amal Elfaitouri2Fredrik Blomberg3Anna Sjösten4Johan Mattson Ulfstedt5Rüdiger Pipkorn6Clas Källander7Christina Öhrmalm8Göran Sperber9Section of Clinical Microbiology, Department of Medical Sciences, Uppsala University, 751 05 Uppsala, SwedenSection of Clinical Microbiology, Department of Medical Sciences, Uppsala University, 751 05 Uppsala, SwedenSection of Clinical Microbiology, Department of Medical Sciences, Uppsala University, 751 05 Uppsala, SwedenSection of Clinical Microbiology, Department of Medical Sciences, Uppsala University, 751 05 Uppsala, SwedenSection of Clinical Microbiology, Department of Medical Sciences, Uppsala University, 751 05 Uppsala, SwedenSection of Clinical Microbiology, Department of Medical Sciences, Uppsala University, 751 05 Uppsala, SwedenDeutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, GermanyCavidi Tech AB, Uppsala Science Park, 751 83 Uppsala, SwedenSection of Clinical Microbiology, Department of Medical Sciences, Uppsala University, 751 05 Uppsala, SwedenDepartment of Neuroscience, Biomedical Centre, Uppsala University, P.O. Box 593, 751 24 Uppsala, SwedenGammaretrovirus-like sequences occur in most vertebrate genomes. Murine Leukemia Virus (MLV) like retroviruses (MLLVs) are a subset, which may be pathogenic and spread cross-species. Retroviruses highly similar to MLLVs (xenotropic murine retrovirus related virus (XMRV) and Human Mouse retrovirus-like RetroViruses (HMRVs)) reported from patients suffering from prostate cancer (PC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) raise the possibility that also humans have been infected. Structurally intact, potentially infectious MLLVs occur in the genomes of some mammals, especially mouse. Mouse MLLVs contain three major groups. One, MERV G3, contained MLVs and XMRV/HMRV. Its presence in mouse DNA, and the abundance of xenotropic MLVs in biologicals, is a source of false positivity. Theoretically, XMRV/HMRV could be one of several MLLV transspecies infections. MLLV pathobiology and diversity indicate optimal strategies for investigating XMRV/HMRV in humans and raise ethical concerns. The alternatives that XMRV/HMRV may give a hard-to-detect “stealth” infection, or that XMRV/HMRV never reached humans, have to be considered.http://dx.doi.org/10.1155/2011/341294 |
| spellingShingle | Jonas Blomberg Ali Sheikholvaezin Amal Elfaitouri Fredrik Blomberg Anna Sjösten Johan Mattson Ulfstedt Rüdiger Pipkorn Clas Källander Christina Öhrmalm Göran Sperber Phylogeny-Directed Search for Murine Leukemia Virus-Like Retroviruses in Vertebrate Genomes and in Patients Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate Cancer Advances in Virology |
| title | Phylogeny-Directed Search for Murine Leukemia Virus-Like Retroviruses in Vertebrate Genomes and in Patients Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate Cancer |
| title_full | Phylogeny-Directed Search for Murine Leukemia Virus-Like Retroviruses in Vertebrate Genomes and in Patients Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate Cancer |
| title_fullStr | Phylogeny-Directed Search for Murine Leukemia Virus-Like Retroviruses in Vertebrate Genomes and in Patients Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate Cancer |
| title_full_unstemmed | Phylogeny-Directed Search for Murine Leukemia Virus-Like Retroviruses in Vertebrate Genomes and in Patients Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate Cancer |
| title_short | Phylogeny-Directed Search for Murine Leukemia Virus-Like Retroviruses in Vertebrate Genomes and in Patients Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Prostate Cancer |
| title_sort | phylogeny directed search for murine leukemia virus like retroviruses in vertebrate genomes and in patients suffering from myalgic encephalomyelitis chronic fatigue syndrome and prostate cancer |
| url | http://dx.doi.org/10.1155/2011/341294 |
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