A Comparative Study of Theoretical Graph Models for Characterizing Structural Networks of Human Brain
Previous studies have investigated both structural and functional brain networks via graph-theoretical methods. However, there is an important issue that has not been adequately discussed before: what is the optimal theoretical graph model for describing the structural networks of human brain? In th...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2013/201735 |
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| _version_ | 1832548061573808128 |
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| author | Xiaojin Li Xintao Hu Changfeng Jin Junwei Han Tianming Liu Lei Guo Wei Hao Lingjiang Li |
| author_facet | Xiaojin Li Xintao Hu Changfeng Jin Junwei Han Tianming Liu Lei Guo Wei Hao Lingjiang Li |
| author_sort | Xiaojin Li |
| collection | DOAJ |
| description | Previous studies have investigated both structural and functional brain networks via graph-theoretical methods. However, there is an important issue that has not been adequately discussed before: what is the optimal theoretical graph model for describing the structural networks of human brain? In this paper, we perform a comparative study to address this problem. Firstly, large-scale cortical regions of interest (ROIs) are localized by recently developed and validated brain reference system named Dense Individualized Common Connectivity-based Cortical Landmarks (DICCCOL) to address the limitations in the identification of the brain network ROIs in previous studies. Then, we construct structural brain networks based on diffusion tensor imaging (DTI) data. Afterwards, the global and local graph properties of the constructed structural brain networks are measured using the state-of-the-art graph analysis algorithms and tools and are further compared with seven popular theoretical graph models. In addition, we compare the topological properties between two graph models, namely, stickiness-index-based model (STICKY) and scale-free gene duplication model (SF-GD), that have higher similarity with the real structural brain networks in terms of global and local graph properties. Our experimental results suggest that among the seven theoretical graph models compared in this study, STICKY and SF-GD models have better performances in characterizing the structural human brain network. |
| format | Article |
| id | doaj-art-675a0e386da2407e9aa4712b2d8dbccf |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-675a0e386da2407e9aa4712b2d8dbccf2025-02-03T06:42:25ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962013-01-01201310.1155/2013/201735201735A Comparative Study of Theoretical Graph Models for Characterizing Structural Networks of Human BrainXiaojin Li0Xintao Hu1Changfeng Jin2Junwei Han3Tianming Liu4Lei Guo5Wei Hao6Lingjiang Li7School of Automation, Northwestern Polytechnical University, Xi'an 710071, ChinaSchool of Automation, Northwestern Polytechnical University, Xi'an 710071, ChinaDepartment of Psychiatry, The Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaSchool of Automation, Northwestern Polytechnical University, Xi'an 710071, ChinaDepartment of Computer Science and Bioimaging Research Center, University of Georgia, Athens, GA 30602, USASchool of Automation, Northwestern Polytechnical University, Xi'an 710071, ChinaDepartment of Psychiatry, The Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Psychiatry, The Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, ChinaPrevious studies have investigated both structural and functional brain networks via graph-theoretical methods. However, there is an important issue that has not been adequately discussed before: what is the optimal theoretical graph model for describing the structural networks of human brain? In this paper, we perform a comparative study to address this problem. Firstly, large-scale cortical regions of interest (ROIs) are localized by recently developed and validated brain reference system named Dense Individualized Common Connectivity-based Cortical Landmarks (DICCCOL) to address the limitations in the identification of the brain network ROIs in previous studies. Then, we construct structural brain networks based on diffusion tensor imaging (DTI) data. Afterwards, the global and local graph properties of the constructed structural brain networks are measured using the state-of-the-art graph analysis algorithms and tools and are further compared with seven popular theoretical graph models. In addition, we compare the topological properties between two graph models, namely, stickiness-index-based model (STICKY) and scale-free gene duplication model (SF-GD), that have higher similarity with the real structural brain networks in terms of global and local graph properties. Our experimental results suggest that among the seven theoretical graph models compared in this study, STICKY and SF-GD models have better performances in characterizing the structural human brain network.http://dx.doi.org/10.1155/2013/201735 |
| spellingShingle | Xiaojin Li Xintao Hu Changfeng Jin Junwei Han Tianming Liu Lei Guo Wei Hao Lingjiang Li A Comparative Study of Theoretical Graph Models for Characterizing Structural Networks of Human Brain International Journal of Biomedical Imaging |
| title | A Comparative Study of Theoretical Graph Models for Characterizing Structural Networks of Human Brain |
| title_full | A Comparative Study of Theoretical Graph Models for Characterizing Structural Networks of Human Brain |
| title_fullStr | A Comparative Study of Theoretical Graph Models for Characterizing Structural Networks of Human Brain |
| title_full_unstemmed | A Comparative Study of Theoretical Graph Models for Characterizing Structural Networks of Human Brain |
| title_short | A Comparative Study of Theoretical Graph Models for Characterizing Structural Networks of Human Brain |
| title_sort | comparative study of theoretical graph models for characterizing structural networks of human brain |
| url | http://dx.doi.org/10.1155/2013/201735 |
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